Correlation of Reproductive Histological Characteristics with Age, 5α-Reductase and Androgens in Arabi Rams (Ovis aries)

Subject Areas : Camel

A. Hamidi ¹ , S. Tabatabaei-Vakili ² , M. Mamouei ³ , S.H. Hosseinifar ⁴

1 - Department of Animal Science, Faculty of Animal Science and Food Technology, Agricultural Science and Natural Resources University of Khuzestan, Mollasani, Khuzestan, Iran
2 - Department of Animal Science, Faculty of Animal Science and Food Technology, Agricultural Science and Natural Resources University of Khuzestan, Mollasani, Khuzestan, Iran
3 - Department of Animal Science, Faculty of Animal Science and Food Technology, Agricultural Science and Natural Resources University of Khuzestan, Mollasani, Khuzestan, Iran
4 - Department of Basic Science, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran

Received: 2023-08-13 Accepted : 2023-11-06 Published : 2023-12-01

Keywords:

References:

Abdul-Rahman I.I., Obese F.Y. and Jeffcoate I.A. (2017). Developmental changes in the histological structure of the testes, and testosterone profiles in male guinea fowls (Numida meleagris). Theriogenology. 101, 114-122.

Aissanou S. and Ayad A. (2022). Histomorphometric changes of testicular tissues by season and age of Algerian local donkeys (Equus asinus). Acta Sci. Anim. Sci. 44, 1-9.

Al-Kawmani A.A., Alfuraiji M.M., Abou-Tarboush F.M., Alodan M.A. and Farah M.A. (2014). Developmental changes in testicular interstitium in the Najdi ram lambs. Saudi J. Biol. Sci. 21(2), 133-137.

Al-Kelaby W.J., Al-Mahmodi A.M.M. and Al-Ramahy A.A.J. (2017). Microscopic and biometric investigations of the testes in adult ram and adult buck in Al-Najaf Al-Ashraf Province. Al-Qadisiyah J. Vet. Med. Sci. 16(2), 105-110.

Andreussi P.A.T., Costa D.S., Faria F.J.C., Fernandes C.A.C., Santos M.D. and Silva J.C.B. (2014). Testicular histomorphometric evaluation of Zebu bull breeds. Braz. Arch. Biol. Technol. 57(6), 900-907.

Baas W.R., Butcher M.J., Lwin A., Holland B., Herberts M., Clemons J., Delfino K., Althof S., Kohler T.S. and McVary K.T. (2018). A review of the FAERS data on 5-alpha reductase inhibitors: implications for postfinasteride syndrome. Urology. 120, 143-149.

Batista R.L. and Mendonca B.B. (2020). Integrative and analytical review of the 5-alpha-reductase type 2 deficiency worldwide. Appl. Clin. Genet. 13, 83-96.

Belibasaki S. and Kouimtzis S. (2000). Sexual activity and body and testis growth in prepubertal ram lambs of Friesland, Chios, Karagouniki and Serres dairy sheep in Greece. Small Rumin. Res. 37(1), 109-113.

Belkhiri Y., Bouzebda-Afri F., Bouzebda Z. and Djaout A. (2017). Testicular morphometric measurements of Ouled Djellal lambs from birth to puberty. Glob. Vet. 18(2), 85-91.

Bormann C.L., Smith G.D., Padmanabhan V. and Lee T.M. (2011). Prenatal testosterone and dihydrotestosterone exposure disrupts ovine testicular development. Reproduction. 142, 167-173.

Boukenaoui N., Moudilou E., Chevalier C., Amirat Z., Exbrayat J.M. and Khammar F. (2012). Postnatal changes in testicular development and androgen receptors immunolocalization in D’Man ram lambs. Folia. Histochem. Cytobiol. 50(1), 38-45.

Chacur M., Arikawa A., Oba E., Souza C. and Filho L.R.G. (2018). Influence of testosterone on body and testicular development in Zebu cattle in the tropical climate. Pp. 91-108 in Advances in Testosterone Action. M. Estrada, Ed., London, United Kingdom.

Davey R.A. and Grossmann M. (2016). Androgen receptor structure, function and biology: from bench to bedside. Clin. Biochem. Rev. 37(1), 3-15.

Elmaz Ö, Dikmen S., Cirit Ü. and Demir H. (2008). Prediction of postpubertal reproductive potential according to prepubertal body weight, testicular size, and testosterone concentration using multiple regression analysis in Kıvırcık ram lambs. Turkish J. Vet. Anim. Sci. 32(5), 335-343.

Emsen E. (2005). Testicular development and body weight gain from birth to 1 year of age of Awassi and Redkaraman sheep and their reciprocal crosses. Small Rumin. Res. 59(1), 79-82.

Falvo S., Di Fiore M.M., Burrone L., Chieffi Baccari G., Longobardi S. and Santillo A. (2015). Androgen and oestrogen modulation by D-aspartate in rat epididymis. Reprod. Fertil. Dev. 28(12), 1865-1872.

Gholami S., Ansari-Lari M. and Khalili L. (2015). Histologic and histomorphometric changes of testis following oral exposure to methyl tertiary-butyl ether in adult rat.  Iranian J. Vet. Res. 16(3), 288-292.

Hadziselimovic F. and Dessouky N. (2008). Differences in testicular development between 5alpha-reductase 2 deficiency and isolated bilateral cryptorchidism. J. Urol. 180, 1116-1120.

Hasani Al-Ameri M. (2022). Evaluation of testicular biometry and spermatozoa recovered after slaughter from cauda epididymal of Awassi ram. Arch. Razi Inst. 77(6), 2329-2334.

Hochereau-de Reviers M.T., Perreau C., Pisselet C., Locatelli A. and Bosc M. (1995). Ontogenesis of somatic and germ cells in sheep fetal testis. J. Reprod. Fertil. 103(1), 41-46.

Imperato-McGinley J., Peterson R.E., Leshin M., Cooper G., Draghi S., Berenyi M. and Wilson J.D. (1980). Steroid 5-reductase deficiency in a 65-year old male pseudohermaphrodite: The natural history, ultrastructure of the testes and evidence for inherited enzyme heterogeneity. Clin. Endocrinol. Metab. 50, 15-22. 

Khasaev A.N., Zubairova M.M., Astarkhanov F.G., Televova N.R., Dagirova F.N. and Gadziyev N.M. (2018). Macro-and microstructure of the sheep testis in the dynamics of postnatal ontogenesis. Plant Arch. 18(2), 2491-2494.

Kolasa A. (2006). Epididymis in an experimental model of DHT deficiency: Immunolocalization of ERalpha and ERbeta in rat epididymal epithelial cells. In vivo and in vitro studies. Ann. Acad. Med. Stetin. 52(2), 13-21.

Kridli R.T., Abdullah A.Y., Momani Shaker M. and Masa'deh M.K. (2007). Sexual activity and puberty in pure Awassi and crosses and backcrosses with Charollais and Romanov sheep breeds. New Zealand J. Agric. Res. 50(4), 429-436.

Luetjens C. and Weinbauer G. (2012). Testosterone: Biosynthesis, transport, metabolism and (non-genomic) actions. Pp. 15-32 in Testosterone: Action, Deficiency, Substitution.  S. Nieschlag, E. Nieschlag and H. Behre, Eds.,  Cambridge University Press, Cambridge, United Kingdom.

Maquivar M.G., Smith S.M. and Busboom J.R. (2021). Reproductive management of rams and ram lambs during the pre-breeding season in US sheep farms. Animals. 11, 1-12.

Moulla F., El-Bouyahiaoui R., Nazih R., Abdelaziz N., Zerrouki N. and Iguer-Ouada M. (2018). Characterization of the onset of puberty in Tazegzawt lambs, an endangered Algerian sheep: Body weight, thoracic perimeter, testicular growth, and seminal parameters. Vet. World. 11(7), 889-894.

Mutalip S.S.M., Singh G.K.S., Shah A.M., Mohamad M., Mani V. and Hussin S.N. (2013). Histological changes in testes of rats treated with testosterone, nandrolone, and stanozolol. Iranian J. Reprod. Med. 11(8), 653-658.

Nazari-Zenouz F., Moghaddama G., Hamidiamb G., Ashrafic J., Rafata S.A. and Qasemi-panahiaa B. (2016). Postnatal testicular development and testosterone changes in Ghezel ram lambs. Small Rumin. Res. 141, 70-76.

Noroozi Asl S., Ibrahimi R., Bagheri S. and Lotfi M. (2023). 5-Alpha reductase deficiency; an important cause of 46, XY DSD: Report of three cases within a family. Clin. Case Rep. J. 11, 1-8.

Paula T.A.R., França L.R. and Garcia H.C. (1999). Seminiferous epithelium cycle and its duration in capybaras (Hydrochoerus hydrochaeris). Tissue Cell. 31(3), 327-334.

Perkins A. and Roselli C.E. (2007). The ram as a model for behavioral neuroendocrinology. Horm. Behav. 52(1), 70-77.

Petrie A. and Watson P. (2013). Statistics for Veterinary and Animal Sciences. Blackwell, London, United Kingdom.

Price E.O., Estep D.Q., Wallach S.J. and Dally M.R. (1991). Sexual performance of rams as determined by maturation and sexual experience. J. Anim. Sci. 69(3), 1047-105.

Robaire B., Ewing L.L., Zirkin B.R. and Irby D.C. (1977). Steroid delta4-5alpha-reductase and 3alpha-hydroxysteroid dehydrogenase in the rat epididymis. Endocrinology. 101(5), 1379-1390.

Robitaille J. and Langlois V.S. (2020). Consequences of steroid-5α-reductase deficiency and inhibition in vertebrates. Gen. Comp. Endocrinol. 290, 1-17.

Rocha L.F., Santana A.L.A., Souza R.S., Machado-Neves M., Oliveira Filho J.C., Santos E.S.C., Araújo M.L., Cruz T.B. and Barbosa L.P. (2022). Testicular morphometry as a tool to evaluate the efficiency of immunocastration in lambs. Anim. Reprod. 19(2), 1-10.

Roshanfekr H., Berg P., Mohammadi K. and Mohamadi M. (2015). Genetic parameters and genetic gains for reproductive traits of Arabi sheep. Biotechnol. Anim. Husb. 31(1), 23-36.

Ruiz-Larrañaga O., Asadollahpour Nanaei H., Montes I., Mehrgardi A.A., Abdolmohammadi A., Kharrati-Koopaee H., Sohrabi S.S., Rendo F., Manzano C., Estonba A., Iriondo M. and Esmailzade A. (2020). Genetic structure of Iranian indigenous sheep breeds: insights for conservation. Trop. Anim. Health Prod. 52, 2283-2290.

Sadi M.S. and Gofur M.R. (2022). Temporal changes in macro and microstructure and seminiferous epithelium of the indigenous sheep testis from birth to puberty. Asian J. Anim. Vet. Adv. 17, 137-145.

Salhaba S.A., Zarkawib M., Wardehc M.F., Al-Masrib M.R. and Kassem R. (2001). Development of testicular dimensions and size, and their relationship to age, body weight and parental size in growing Awassi ram lambs. Small Rumin. Res. 40, 187-191

Shukla P., Bhardwaj R.L. and Rajput R. (2013). Histomorphology and micrometry of testis of chamurthi horse. Indian J. Vet. Anat. 25(1), 36-38.

SPSS Inc. (2011). Statistical Package for Social Sciences Study. SPSS for Windows, Version 20. Chicago SPSS Inc., USA.

Vija L., Ferlicot S., Paun D., Bry-Gauillard H., Berdan G., Abd-Alsamad I., Lombès M. and Young J. (2014). Testicular histological and immunohistochemical aspects in a post-pubertal patient with 5 alpha-reductase type 2 deficiency: Case report and review of the literature in a perspective of evaluation of potential fertility of these patients. BMC Endocrinol. Disor. 14, 1-9.

Wada T., Ichikawa C., Takeuchi M., Matsui F., Matsumoto F., Ida S., Etani Y. and Kawai M. (2022). Histological analysis of testes in patients with 5 alphareductase deficiency type 2: Comparison with cryptorchid testes in patients without endocrinological abnormalities and a review of the literature. Clin. Pediatr. Endocrinol. 31(3), 144-151.

Wilson J.D., George F.W. and Renfree M.B. (1995). The endocrine role in mammalian sexual differentiation. Recent Prog. Horm. Res. 50, 349-364.

Zhu Y. and Imperato-McGinley J. (2008). Male sexual differentiation disorder and 5α-reductase-2 deficiency. J. Glob. Libr. Women's Med. 2008, 1-12.