اثر گونه های اکسیژن فعال بر اسپرم: عملکرد متوازن سودمند و زیانبار

Subject Areas : Camel

اس. ساراسوات ¹ (Male Reproduction Laboratory, PRSM Division,Central Institute for Research on Goats, Makhdoom,Farah, Mathura, 281122, India)
اس.دی. خرچه ² (Male Reproduction Laboratory, PRSM Division,Central Institute for Research on Goats, Makhdoom,Farah, Mathura, 281122, India)
اس.کا. جینتا ³ (Male Reproduction Laboratory, PRSM Division,Central Institute for Research on Goats, Makhdoom,Farah, Mathura, 281122, India)

Received: 2013-01-20 Accepted : 2013-03-16 Published : 2014-03-01

Keywords: منی, گونه های اکسیژن فعال,

Abstract :

گونه­های اکسیژن فعال (ROS) نقش مهمی در تحرک اسپرم دارند. تولید فیزیولوژیکی آن‌ها در غلظت­های پایین سبب القای آثار سودمند بر عملکرد اسپرم شده و نقش مهمی در سوخت و ساز اسپرم ایفا می­نمایند. در ضمن، تولید بیش از حد گونه­های اکسیژن فعال می­تواند مکانیسم حفاظتی را خنثی نموده و سبب بروز تغییراتی در لایه­های چربی و پروتئینی غشای پلاسمایی اسپرم شود. این امر سبب ایجاد آسیب در چربی، پروتئین و DNA شده و باعث ایجاد اختلال در تحرک اسپرم و تغییر در ظرفیت­پذیری و واکنش آکروزومی می­شود. گونه­های اکسیژن فعال (ROS) می­توانند به وسیله نشانگرهای زیستی مختلفی نظیر غلظت مالون دی آلدئید، رادیکال­های آزاد منفرد و غیره اندازه­گیری شوند. شیوه‌ی تعیین کمّی رادیکال­های آزاد در منی حیوانات مزرعه­ای نیز به اختصار گزارش می­شود.

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