مروری بر ژن های عمده مؤثر بر چندقلوزایی و مکانیسم های مرتبط در گوسفند
Subject Areas : Camelام.ام. مستهافا 1 , اف.ام.ام.تی. ماریکار 2
1 - National Institute of Animal Science and Veterinary Medicine, China Agricultural University, 2 West Yuanmingyuan Road, Beijing 100193,China
2 - Department of Biochemistry, Faculty of Medicine and Allied Science, University of Rajarata, Saliyapura, Anuradhapura, Sri Lanka
Keywords: گوسفندهای برولا مرینو, انتخاب فولیکولی, میزان تخمک گذاری, سودمندی,
Abstract :
هدف از این مطالعه مروری، بررسی پیشرفتهای کنونی در شناسایی ژنهای فعال در نژادهای گوسفند چندقلوزا و مکانیسمهای مؤثر بر آنها و بررسی فرصتهای مطالعاتی آینده در این زمینه است. هدف نهایی در پرورش حیوانات مزرعهای، کسب کارآیی بوده و چندقلوزایی نیز یک ویژگی کلیدی در تعیین کارآیی حیوانات مزرعهای به شمار میرود. نرخ تخمک گذاری در پستانداران یک فرآیند پیچیده بوده که تحت تأثیر ژنتیک و مسیرهای هورمونی درونریز است. از زمان کشف گوسفند برولا مرینو، بالا بودن تواناییهای تولیدمثلی در قالب نرخ تخمک گذاری بالا در اکثر نژادهای گوسفند در سرتاسر دنیا مطالعه شده است. جهشهایی که بهصورت طبیعی رُخ داده و بر چندقلوزایی مؤثر هستند، در کروموزوهای 5، 6، 11 و X دیده میشوند. ولی تصور میشود که جهشهای بیشتری بر روی ژنهای مختلف در نژادهای گوسفند دارای قابلیت تخمک گذاری چندگانه تأثیر میگذارند. مکانیسمهای کنترل کننده تخمکگذاری چند گانه و چندقلوزایی در این نژادهای گوسفند هنوز به خوبی مطالعه و شناخته نشدهاند. در سالهای گذشته مکرراً نشان داده شده است که گُنادوتروپینها و عوامل درون تخمدانی نقشهای حیاتی و متفاوتی را در این فرآیند ایفا میکنند. القای تنظیم هورمونی فولیکولها در طی فولیکولزایی، میتواند یکی از زمینههای مطالعاتی در آینده باشد. در بین عوامل درون تخمدانی، سامانه پروتئین ریختزایی استخوان یکی از مؤلفههای ضروری است که برای دستورزی فولیکولزایی تخمدانی به طور وسیعی در مجامع علمی در حال مطالعه و بررسی است. علاوه بر این، وظایف بیولوژیکی و فیزیولوژیکی خانواده پروتئین ریختزایی استخوان کاملاً شناخته شده نبوده و یافتههای متناقض در بین پستانداران نیز قدری کار را پیچیده نموده و چالشهایی را ایجاد کرده است که در آینده باید حل شوند. این مطالعه معتقد است که یک حلقه کنترل تنظیمی بین اووسیت، گرنولوزا و سلولهای تیکا از طریق خانواده TGFB وجود دارد.
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