Expression of Toll-Like Receptor4 (TLR4) in Pancreas of Obese Chicken

Subject Areas : Camel

S.K. Pathak ¹ , P. Suvaneeth ² , E. Raja Ravi Teja ³

1 - Department of Veterinary Anatomy, Faculty of Veterinary and Animal Science, Institute of Agricultural Science, Rajiv Gandhi South Campus, Banaras Hindu University, Barkachha, Mirzapur, Uttar Pradesh, India
2 - Department of Veterinary Pathology, Faculty of Veterinary and Animal Science, Institute of Agricultural Science, Rajiv Gandhi South Campus, Banaras Hindu University, Barkachha, Mirzapur, Uttar Pradesh, India
3 - Department of Veterinary Anatomy, Faculty of Veterinary and Animal Science, Institute of Agricultural Science, Rajiv Gandhi South Campus, Banaras Hindu University, Barkachha, Mirzapur, Uttar Pradesh, India

Received: 2022-09-14 Accepted : 2022-12-08 Published : 2023-03-01

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References:

Becker W.A., Spencer J.V., Mirosh L.W. and Verstrate J.A. (1979). Prediction of fat and fat free live weight in broiler chickens using back skin fat, abdominal fat and live body weight. Poult. Sci. 58, 835-842.

Eguchi K., Manabe I., Oishi-Tanaka Y., Ohsugi M., Kono N., Ogata F., Yagi N., Ohto U., Kimoto M. and Miyake K. (2012). Saturated fatty acid and TLR signaling link β cell dysfunction and islet inflammation. Cell Metab. 15, 518-533.

Fessler M.B., Rudel L.L. and Brown J.M. (2009). Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome. Curr. Opin. Lipidol. 20, 379-385.

Goldberg A., Parolini M., Chin B.Y., Czismadia E., Otterbein L.E., Bach F.H. and Wang H. (2007). Toll-like receptor 4 suppression leads to islet allograft survival. FASEB J. 21, 2840-2848.

Griffin C., Eter L. and Lanzetta N., Abrishami S., Varghese M., McKernan K., Muir L., Lane J., Lumeng C.N. and Singer K. (2018). TLR4, TRIF, and MyD88 are essential for myelopoiesis and CD11c(+) adipose tissue macrophage production in obese mice. J. Biol. Chem. 293(23), 8775-878.

Hwang D.H., Kim J.A., Lee J.Y. and Heikkinen A. (2016). Mechanisms for the activation of Toll-like receptor 2/4 by saturated fatty acids and inhibition by docosahexaenoic acid. European J. Pharmacol. 785, 24-35.

Kim J.J. and Sears D.D. (2010). TLR4 and insulin resistance. Gastroenterol. Res. Pract. 2010, 1-11.

Lee J.Y., Sohn K.H., Rhee S.H. and Hwang D. (2001). Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. J. Biol. Chem. 276, 16683-16689.

Lee J.Y., Plakidas A., Lee W.H., Heikkinen A., Chanmugam P., Bray B. and Hwang D.H. (2003). Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids. J. Lipid Res. 44(3), 479-486.

Li Y., Zhou Z.G., Xia Q.J., Zhang J., Li H.G., Cao G.Q., Wang R., Lu Y.L. and Hu T.Z. (2005). Toll-like receptor 4 detected in exocrine pancreas and the change of expression in cerulein-induced pancreatitis. Pancreas. 30(4), 375-381.

McKernan K., Varghese M., Patel R. and Singer K. (2020). Role of TLR4 in the induction of inflammatory changes in adipocytes and macrophages. Adipocyt. 9(1), 212-222.

Thomas V.G., Mainguy S.K. and Prevett J.P. (1983). Predicting fat-content of geese from abdominal fat weight. J. Wildl. Manage. 47, 1115-1119.

Vives-Pi M., Somoza N., Fernández-Alvarez J., Vargas F., Caro P., Alba A., Gomis R., Labeta M.O. and Pujol-Borrell R. (2003). Evidence of expression of endotoxin receptors CD14, toll-like receptors TLR4 and TLR2 and associated molecule MD-2 and of sensitivity to endotoxin (LPS) in islet beta cells. Clin. Exp. Immunol. 133, 208-218.

Weatherill A.R., Lee J.Y. and Zhao L., Lemay D.C., Youn H.S. and Hwang D.H. (2012). Saturated and polyunsaturated fatty acids reciprocally modulate dendritic cell functions mediated through TLR4. J. Immunol. 174(9), 5390-5397.