فعالیت های ضدمالاریا Breynia Nivosa

Subject Areas : Journal of Medicinal Herbs, "J. Med Herb" (Formerly known as Journal of Herbal Drugs or J. Herb Drug)

جود اکوکون ¹ (گروه فارماکولوژی و سم شناسی، دانشکده داروسازی، دانشگاه Uyo، Uyo، نیجریه.)
کوفرش داویس ² (گروه فیزیولوژی، دانشکده علوم پزشکی، دانشگاه Uyo، Uyo، نیجریه.)
آزار ب.آ ³ (گروه علوم زیستی، دانشگاه ابوجا، نیجریه.)

Received: 2014-01-05 Accepted : 2015-05-11 Published : 2015-01-01

Keywords: Antiplasmodial, Breynia nivosa, ضدمالاریا, درمان گیاهی,

Abstract :

Background & Aim: Antiplasmodial activity of leaf extract of Breynia nivosa was evaluated to ascertain the folkloric claim of its antimalarial activity. Experimental: The crude leaf extract (75 – 225 mg/kg), of Breynia nivosa was investigated for antiplasmodial activity against chloroquine sensitive Plasmodium berghei infections in mice. The antiplasmodial activity during early and established infections as well as prophylactic were investigated. Artesunate 5 mg/kg and pyrimethamine 1.2 mg/kg were used as positive controls. Thin films made from tail blood of each mouse were used to assess the level of parasitaemia of the mice. Results & Discussion: The extract dose-dependently reduced parasitaemia induced by chloroquine sensitive Plasmodium berghei infection in prophylactic, suppressive and curative models in mice. These reductions were statistically significant (p<0.001). They also improved the mean survival time (MST) from 11 to 27 days relative to control control (p     Industrial and practical recommendations: The plant, Breynia nivosa, possesses antimalarial property which can be exploited in the treatment of malaria.

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