Antibacterial activity of Nigerian medicinal plants as panacea for antibiotic resistance: A systematic review

Subject Areas : Journal of Medicinal Herbs, "J. Med Herb" (Formerly known as Journal of Herbal Drugs or J. Herb Drug)

Adam Mustapha ¹ , Obi Chidiebere ² , Fasogbon Victor ³ , Mshelia Bata ⁴ , Nuhu Tanko ⁵ , Micheal Yakubu ⁶ , Zenoh Ali ⁷ , Alegbe David ⁸

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Received: 2022-05-09 Accepted : 2022-08-14 Published : 2022-11-22

Keywords: Medicinal Plants, Antibiotic resistance, Antibacterial, Nigerian, Systematic literature review,

Abstract :

Background & Aim: Antibiotic resistance is one of the global public health threats facing modern health care system. The development of new effective agents has been challenging. Thus, the interest in the use of medicinal plants for the treatment of bacterial infections has increased. Therefore, the aim of this study was to review Nigerian medicinal plants with antibacterial activity.Experimental: This study retrieved data from published articles on Nigerian medicinal plants with antibacterial activity. The Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines were adopted. A systematic search of PUBMED CENTRAL was conducted. The included studies were those published in peer-reviewed English language journals between 1st January 2000 and 31st December 2020 and reported on the key terms; Nigerian medicinal plants with antibacterial activity.Results: The database searches yielded a total of 817 results, and 765 articles were ineligible. After reviewing relevant titles and abstracts, a total of 52 articles on antibacterial were retrieved for full text review. After extensive review of each article, 13 articles were excluded and a total of 39 articles were retained. Furthermore, 4 articles were also removed due to lack of specific compounds stated. Finally, only 35 articles met the inclusion criteria for the assessment of antibacterial activity of Nigerian medicinal plants. The narrative synthesis of the included studies revealed different plants families with broad activities against gram-positive and gram-negative bacteria. Among the bacterial isolates, Staphylococcus aureus was tested more, followed by Escherichia coli and Pseudomonas aeruginosa and the bacteria were subjected to 97 medicinal plants species for antibacterial activity.Recommended applications/industries: The results from this study reveal that many Nigerian medicinal plants contain bioactive compounds with potentials of antibacterial activity and suggest that they could be employed as alternative in the treatment of bacterial infections after safety profiles is appraised.

References:

Abiala, M., Olayiwola, J., Babatunde, O., Aiyelaagbe, O., and Akinyemi, S. 2016. Evaluation of therapeutic potentials of plant extracts against poultry bacteria threatening public health. BMC Complementary and Alternative Medicine, 16 (417): 1-8.

Abioye, E.O., Akinpelu, D.A., Aiyegoro, O.A., Adegboye, M.F., Oni, M.O. and Okoh, A.I. 2013.  Preliminary phytochemical screening and antibacterial properties of crude stem bark extracts and fractions of Parkia biglobosa (Jacq.). Molecules, 18:8485-8499.

Akindele, D.A., Abioye, E.O., Aiyegoro, O.A., Akinpelu, O.F., Okoh AI. 2015. Evaluation of antibacterial and antifungal Properties of Alchornea laxiflora (Benth.) Pax. & Hoffman. Evidence-Based Complementary and Alternative Medicine, 1-6.  

Akinpelu, D.A., Aiyegoro, O.A., Akinpelu, O.F., and Okoh, A.I. 2015. Stem Bark Extract and Fraction of Persea americana (Mill.) Exhibits Bactericidal Activities against Strains of Bacillus cereus associated with Food Poisoning. Molecules, 20:416-429.

Akinsulire, O.R., Aibinu, I.E., Adenipekun, T., Adelowotan, T., and Odugbemi, T. 2007. In vitro antimicrobial activity of crude extracts from plants bryophyllum pinnatum and kalanchoe crenata. African Journal of Traditional Complementary Alternative Medicine, 2 (7): 338-344.

Akinyele, T.A., Okoh, O.O., Akinpelu, D.A., and Okoh, A.I. 2011. In-Vitro antibacterial properties of crude Aqueous and n-Hexane extracts of the Husk of Cocos nucifera. Molecules, 16: 2135-2145.

Akinyemi, K.O., Oladapo, O., Okwara, C.E., Ibe, C.C., and Fasure, K.A. 2005. Screening of crude extracts of six medicinal plants used in South-West Nigerian unorthodox medicine for anti-methicillin resistant Staphylococcus aureus activity. BMC Complementary and Alternative Medicine, 5(6):1-7. 

Aladesanmi, A.J., Iwalewa, E.O., Adebajo, A.C., Akinkunmi, E.O., Taiwo, B.J., Olorunmola, F.O., and Lamikanra, A. 2007. Antimicrobial and antioxidant activities of some Nigerian medicinal plants. African Journal of Traditional Complementary Alternative Medicine, 4 (2): 173-184.

Anibijuwon, I., Gbala, I., Abioye, J. 2018. Susceptibility of Selected Multi-Drug Resistant Clinical Isolates to Leaves of Carpolobialutea. Ethiopian Journal of Health Science, 28 (2): 117-124.

Anyanwu, M.U., and Okoye, R.C. 2017. Antimicrobial activity of Nigerian medicinal plants. Journal of Intercultural Ethnopharmacology, 6(2): 240-259.

Asokan1, G.V., Tufoof, R., Eman, A., and Hala, S.2019.WHO Global Priority Pathogens List: A Bibliometric Analysis of MedlinePubMed for Knowledge Mobilization to Infection Prevention and Control Practices in Bahrain. Oman Medical Journal, 34(3): 184-193.

Atolani, O., Adamu, N., Oguntoye, O.S., Zubair, M.F., Fabiyi, O.A., Oyegoke, R.A., Adeyemi, O.S., Areh, E.T., Tarigha, D.E., Kambizi, L., and Olatunji, G.A. 2020. Chemical characterization, antioxidant, cytotoxicity, Anti-Toxoplasma gondii and antimicrobial potentials of the Citrus sinensis seed oil for sustainable cosmeceutical production. Heliyon, 6 (e03399): 1-11.

Bankole, M.A., Shittu, L.A.J., Titilade, A.A., Bankole, M.N., Shittu, R.K., Terkula, K., Ashiru, O.A.  2007. Synergistic antimicrobial activities of phytoestrogens in crude extracts of two sesame species against some common pathogenic microorganisms. African Journal of Traditional Complementary Alternative Medicine, 4(4): 427-433.

Christiana, B.A.A., Lawal, T.O., and Mahady, G.B. 2009. In vitro susceptibility of Helicobacter pylori to extracts of Eucalyptus camaldulensis and Eucalyptus torelliana. Pharmaceutical Biology, 1 (47): 99–102.

Dada, A.O., Adekola, F.A., Dada, F.E., Adelani-Akande, A.T., Bello, M.O., Okonkwo, C.R., Inyinbor,   A.A., Oluyori, A.P., Olayanju, A., Ajanaku, K.O., and Adetunji, C.O. 2019. Silver nanoparticle synthesis by Acalypha wilkesiana extract: phytochemical screening, characterization, influence of operational parameters, and preliminary antibacterial testing. Heliyon, 5 (e02517): 1-8.

De Kraker, M.E.A., Stewardson, A.J., Harbarth, S. 2016. Will 10 million people die a year due to antimicrobial resistance by 2050? PLoS Medicine, 13: e1002184.

Eleyinmi, A.F.2007. Chemical composition and antibacterial activity of Gongronema latifolium. Journal of Zhejiang University SCIENCE B, 8(5): 352-358.

Enemchukwu, C.M., Oli, A.N., Okoye, E.I., Ujam, N.T., Osazuwa, E.O., Kenneth, G.O., Okeke, E.N., Ifezulike, C.C., Ejiofor, O.S., and Okoyeh, J.N. 2019. Winning the War against Multi-Drug Resistant Diarrhoeagenic Bacteria. Microorganisms, 7(197): 1-15.

Essien, E.E., Newby, J.S., Walker, T.M., Setzer, W.N., and Ekundayo, O. 2016. Characterization and Antimicrobial Activity of Volatile Constituents from Fresh Fruits of Alchornea cordifolia and Canthium subcordatum. Medicines, 3(1): 2-10.

European Medicines Agency and the European Centre for Disease Prevention and Control. 2009. The bacterial challenge – time to react. A call to narrow the gap between multidrug-resistant bacteria in the EU and development of new antibacterial agents. London, European Medicines Agency. 2009. Available on internet at: https://ecdc.europa.eu/sites/portal/files/media/en/publications/ Publications/0909.

Ezeorba, T.P.C., Chukwudozie, K.I., Ezema, C.A., Anaduaka, E.G., Nweze, E.J., and Okeke, E.S. 2022.  Potentials for health and therapeutic benefits of garlic essential oils: Recent findings and future prospects. Pharmacological Research - Modern Chinese Medicine, 3(100075): 1-15.

Falodun, A., Erharuyi, O., Imieje, V., Ahomafor, J., Akunyuli, C., Jacobs, M., Khan, S., Hamann, M.T., and Langer, P. 2014. In vitro evaluation of aliphatic fatty alcohol metabolites of Perseaamericana seed as potential antimalarial and antimicrobial agents. Nigerian Journal of Biotechnology, 27: 1-7.

Falodun, A., Imieje, V., Erharuyi, O., Joy, A., Langer, P., Jacob, M., Khan, S., Abaldry, M., Hamann, M. 2014. Isolation of antileishmanial, antimalarial and antimicrobial metabolites from Jatropha multifida. Asian Pacific Journal of Tropical Biomedicine, 4 (1): 374-378.

Huttner, A., Harbarth, S., Carlet, J., Cossgrove, S., Goossens, H., Holmes, A, et al. 2013. Antimicrobial resistance: A global view from the 2013 world Healthcare-Associated infections Forum. Antimicrobial Resistance Infection Control, 1(134): 1-30.

Ibekwea, N.N., Nvaua, J.B., Oladosua, P.O., Usmana, A.M., Ibrahima, K., Boshoffc, H.I., Dowdc, C.S., Orisadipea, A.T., Aiyelaagbeb, O., Adesomojub, A.A., Barry, C.E., Okoguna, J.I., and in collaboration with 73 Visited Herbalists. 2014. Some Nigerian Anti-Tuberculosis Ethnomedicines: A Preliminary Efficacy Assessment. Journal of Ethnopharmacology, 55: (1) 524–532.

Isa, A.I., Awouafack, M.D., Dzoyem, J.P., Aliyu, M., Magaji, R.A., Ayo, J.O., and Eloff, J.N. 2014. Some Strychnos spinosa (Loganiaceae) leaf extracts and fractions have good antimicrobial activities and low cytotoxicities. BMC Complementary and Alternative Medicine, 14(456): 2-8.

Li, J., Feng, W., Dai, R., and Li, B. 2022. Recent Progress on the Identification of Phenanthrene Derivatives in Traditional Chinese Medicine and Their Biological Activities. Pharmacological Research - Modern Chinese Medicine, 3(100078): 1-44.

Murray, C.J.L., Ikuta, K.S., Sharara, F., Swetschinski, L., Aguilar, G.R., Gray A. et al. 2022. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet, 399: 629–655.

Mustapha, A., Disa, H.A., and Balaman, N. 2017. Antibacterial activity of Salvadora persica (chewing stick) on Streptococcus mutans isolates from patients attending University of Maiduguri Teaching Hospital’s Dental Unit. Indian Journal of Research, 4(6): 715-717.

Nwidu, L.L., Nwaforb, P.A., and Vilegas, W. 2012. Antimicrobial activity of carpolobia lutea extracts and fractions. African Journal of Traditional Complementary Alternative Medicine, 9(3): 323-328.

Nwodo, U.U., Obiiyeke, G.E., Chigor, V.N., Okoh, A.I. 2011. Assessment of Tamarindus indica extracts for antibacterial activity. International Journal of Molecular Sciences, 12: 6385-6396.

O’Neill, J. 2016. Tackling drug-resistant infections globally: final report and recommendations. London: Review on Antimicrobial Resistance. Available on internet at: https://wellcomecollection.org/works/thvwsuba.

Ogbole, O.O., Ndabai, N.C., Akinleye, T.E., and Attah, A.F. 2020. Evaluation of peptide-rich root extracts of Calliandria portoriscensis (Jacq.) Benth (Mimosaceae) for in vitro antimicrobial activity and brine shrimp lethality. BMC Complementary and Alternative Medicine, 20(30): 1-7.

Okoye, T.C., Akah, P.A., Okoli, C.O., Ezike, A.C., Omeje, E.O., Odoh, U.E. 2012. Antimicrobial Effects of a Lipophilic Fraction and Kaurenoic acid isolated from the root bark extracts of Annona senegalensis. Evidence-Based Complementary and Alternative Medicine, 1-10.

Oladosu, I.A., Balogun, S.O., and Zhi-Qiang, L. 2015. Chemical constituents of Allophylus africanus. Chinese Journal of Natural Medicines, 13(2): 133–141.

Olajubu, F.A., Akpan, Ojo, D.A., and Oluwalana, S.A. 2012. Antimicrobial potential of Dialium guineense (Wild.) stem bark on some clinical isolates in Nigeria. International Journal of Applied and Basic Medical Research, 2(1): 58-62.

Olajuyigbe, O.O., Adedayo, O., and Coopoosamy, R.M. 2020. Antibacterial Activity of Defatted and Nondefatted Methanolic Extracts of Aframomum melegueta K. Schum. against Multidrug-resistant bacteria of clinical importance. The Scientific World Journal, 1-8.

Oluwasina, O.O., Ezenwosu, I.V., Ogidi, C.O., and Oyetayo, V.O. 2019. Antimicrobial potential of toothpaste formulated from extracts of Syzygium aromaticum, Dennettia tripetala and Jatropha curcas latex against some oral pathogenic microorganisms. AMB Express, 9(20): 1-13.

Oramadike, C.E., and Ogunbanwo, S.T. 2017. Antagonistic activity of Thymus vulgaris extracts against Vibrio species isolated from seafoods. Journal of Food Science Technology, 54(5): 1199–1205.

Oriola, A.O., Aladesanmi, A.J., Idowu, T.O., Akinkunmi, E.O., Obuotor, E.M., and Ogunsina, M.O. 2014. A new bioactive thiophenolic glycoside from the leaf of massularia acuminata (g. Don bullock) ex hoyle (rubiaceae). African Journal of Traditional Complementary Alternative Medicine, 11(2): 319-323.

Oyedemi, B.O., Oyedemi, S.O., Chibuzor, J.V., Ijeh, I.I., Coopoosamy, R.M., and Aiyegoro, A.O. 2018.  Pharmacological Evaluation of Selected Medicinal Plants Used in the Management of Oral and Skin Infections in Ebem-Ohafia District, Abia State, Nigeria. The Scientific World Journal, 4757458:1-16.

Page, M.J., McKenzie, J.E., Bossuyt, P.M., Boutron, I., Hoffmann, T.C., Mulrow, C.D., et al. 2021. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ, 372: n71.

Sonibare, M.A., Soladoye, M.O., Esan, O.O., and Sonibare, O.O. 2009. Phytochemical and antimicrobial studies of four species of cola schott & endl. (sterculiaceae). African Journal of Traditional Complementary Alternative Medicine, 6(4): 518-525.

Udegbunam, S.O., Udegbunam, R.I., Nnaji, T.O., Anyanwu, M.U., Chukwujekwu-Kene, R.O., Anika, S.M. 2015. Antimicrobial and antioxidant effect of methanolic Crinum jagus bulb extract in wound healing. Journal of Intercultural Ethnopharmacology, 4(3): 239-248. 

Ugboko, H.U., Nwinyi, O.C., Oranusi, S.U., Fatoki, T.H., and Omonhinmin, C.A. 2020 Antimicrobial importance of medicinal plants in Nigeria. The Scientific World Journal, 7E+06: 1-10.

Ugoh, S.C., Agarry, O.O., Garba, and S.A. 2014. Studies on the antibacterial activity of Khaya senegalensis [(Desr.) A. Juss)] stem bark extract on Salmonella enterica subsp. enterica serovar Typhi [(ex Kauffmann and Edwards) Le Minor and Popoff. Asian Pacific Journal of Tropical Biomedicine, 4(1): 279-283.

World Health Organization: Antibiotic resistance: Multi-country public awareness survey I. 2015. World Health Organization. ISBN 978 92 4 150981 7 Subject   headings     are     available     from      WHO

institutional repository. Available on internet at: http://apps.who.int/iris/bitstream/10665/194460 /1/9789241509817_eng. pdf ?ua=1.

World Health Organization. 2001. Legal Status of Traditional Medicine as Complementary and Alternative Medicine. A World Review, Geneva. Available on internet at: https://apps.who.int/iris/handle/10665/42452