فهرس المقالات cytotoxic activity

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  1 - Ficusanol, a new cinnamic acid derivative and other constituents from the roots of <i>Ficus exasperata</i> Vahl. (Moraceae) with antioxidant and cytotoxic activities
  Stevine Claudiale Popwo Tameye Jean Claude Ndom Edwige Laure Nguemfo Jean Duplex Wansi Juliette Catherine Vardamides Anatole Guy Blaise Azebaze
  Phytochemical investigation of the roots of Ficus exasperata Vahl. (Moraceae) led to the isolation of a new cinnamic acid derivative, named ficusanol (1) along with eleven known compounds: 3-(6-methoxybenzo[b]furan-5-yl)propenoic acid (2), bergapten (3), oxypeucedanin h أکثر

  Phytochemical investigation of the roots of Ficus exasperata Vahl. (Moraceae) led to the isolation of a new cinnamic acid derivative, named ficusanol (1) along with eleven known compounds: 3-(6-methoxybenzo[b]furan-5-yl)propenoic acid (2), bergapten (3), oxypeucedanin hydrate (4), marmesin (5), decursinol (6), aridanin (7), betulinic acid (8), maslinic acid (9), a mixture of stigmasterol (10) and &beta;-sitosterol (11), and sitosteryl-3-O-&beta;-D-glucopyranoside (12). The structures of the new compound as well as those of the known ones were established by the means of usual spectroscopic methods: NMR (1H, 13C, DEPT, COSY, HSQC and HMBC) data and HR-ESIMS data. Crude extract and compounds 1, 2, 5, 6 and 7 were evaluated for their radical scavenging potency using DPPH (2,2-diphenyl-1-picrylhydrazyl) assay. Accordingly, the compound 6 showed significant antioxidant activity with IC50 = 25.10 &plusmn; 0.91 &micro;g/mL, whereas the other compounds showed only moderate activity at high concentrations. Compounds 2, 6 and 7 were also evaluated for their cytotoxic activity among which the compound 7 exhibited a strong cytotoxic activity with a viability percentage of 3.5% on mouse lymphoma cell line L5178Y. تفاصيل المقالة
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  2 - Comparative GC-MS Analysis, Antioxidant and cytotoxic activities of Garcinia kola Heckel seed and stem-bark n-hexane extract
  سیده آکورو اوینلاد اوگوندار آدکونله اویدولا
  10.30495/medherb.2023.707916
  Background &amp; Aim: Garcinia kola is one of the well-known tropical medicinal plants known in the traditional management of several diseases especially connected with inflammatory and degenerative diseases. This study was designed to compare the phytochemical contents أکثر

  Background &amp; Aim: Garcinia kola is one of the well-known tropical medicinal plants known in the traditional management of several diseases especially connected with inflammatory and degenerative diseases. This study was designed to compare the phytochemical contents and cytotoxic activities of crude G. kola n-hexane seed and stem-bark extracts by Gas Chromatography-Mass Spectrometry (GC-MS).Experimental: Fresh seeds and stem-bark of G. kola were collected, authenticated and extracted by macerating in n-hexane separately. The compounds in the crude extracts were evaluated using Gas Chromatography-Mass Spectrophotometer (GC-MS). The cytotoxic activity was determined using the brine shrimp lethality assay.Results: Extraction of the plant materials yielded the crude n-hexane extracts GKSE and GKBE from the G. kola seed and stem-bark, respectively. GC-MS analysis detected 54 and 34 compounds in GKSE and GKBE, respectively. The most abundant compounds in both extracts were Lanosta-8,24-dien-3-one and Oxacycloheptadec-8-en-2-one with percentage abundance of 20.72% and 22.71%, respectively. The stem-back extract (LC50=42.76&plusmn;1.85 &mu;g/mL) showed better cytotoxic activity than the seed extract (LC50=73.15&plusmn;1.51 &mu;g/mL). GC-MS results for both extracts indicated compounds known for their antioxidant and anticancer properties which may explain some of the various ethno-medical uses of G. kola seed and stem-bark.Recommended applications/industries: This plant could be a source of a new anticancer drug. تفاصيل المقالة