فهرس المقالات benign prostatic

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  1 - South American medicinal plants for the symptomatic treatment of benign prostatic hyperplasia: A systematic review
  الیانا سولورزانو پائولو پاستور دیوید گریسفی
  10.30495/medherb.2022.697736
  Background & Aim: Benign prostatic hyperplasia (BPH) is one of the prevalent age-related medical conditionin men. In the last 20 years, alternative therapies, especially those based on herbs, are increasingly preferred. The most popularly consumed herb is Serenoa re أکثر

  Background & Aim: Benign prostatic hyperplasia (BPH) is one of the prevalent age-related medical conditionin men. In the last 20 years, alternative therapies, especially those based on herbs, are increasingly preferred. The most popularly consumed herb is Serenoa repens, a plant growing in the subtropical south-eastern United States which has shown very efficient results compared to pharmacological conventional treatments both in terms of cost and risks associated with them. Nevertheless, the same trial found no difference between S. repens and placebo according to the American Urological Association Symptom Score Index. As more and more consumers are turning increasingly towards natural therapies, it would be appropriate to promote the recognition of the value of other medicinal plants with potential applicability through comprehensive research. For this purpose, a descriptive comparison between several South-American plants little publicised in the pharmaceutical market is presented to slightly narrow the gap between the reliable evidence-based and popular information for consumers and the pharmaceutical industry.Experimental: With this approach, a review of the literature was conducted through an electronic consultation of two databases, Science Direct and Google Scholar™.Results: This narrative review highlights the wide range of natural medicines available for controlling the inflammatory symptoms of the lower urinary tract, which could be more explored from a pharmacological and chemical point of view.Recommended applications/industries: The future use of natural products requires further investment in pre-clinical research and in clinical trials that investigate stability and a profitable pharmacokinetic/pharmacodynamic ratio. Although they are well tolerated and used daily by South American populations, the industry's proper commercial focus on these natural remedies cannot be separated from appropriate phyto-vigilance actions promoted تفاصيل المقالة
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  2 - Effects of combined ethanol extract of Anthocleista vogelii and Alstonia boonei stem barks on sex hormonal levels of benign prostatic hyperplasia (BPH) induced rats
  رابرت اوروکو چوکو چارلز نانا جوسفات اکور داوید اباسی نیکیو ازوگو
  10.30495/medherb.2021.682890
  Background & Aim:Combined ethanol extract of A. vogelii and A. boonei stem (CEAA) barks is commonly used to treat prostate disorders whereas its effects on benign prostatic hyperplasia (BPH) has not been scientifically validated. This study investigated the effects أکثر

  Background & Aim:Combined ethanol extract of A. vogelii and A. boonei stem (CEAA) barks is commonly used to treat prostate disorders whereas its effects on benign prostatic hyperplasia (BPH) has not been scientifically validated. This study investigated the effects of CEAA on prostate weight, prostate index and serum androgenic and estrogenic hormonal levels of BPH induced rats.Experimental: The study had 6 groups containing 5 male Wistar albino rats each. Group 1 was the normal control rats without BPH induction while group 2 was the BPH induced rats without any treatment (BPH) control. Groups 3 – 5 were BPH induced rats treated with 5 mg/kg finasteride/day, 200 and 400 mg/kg CEAA/day, respectively. BPH was induced in groups 2 – 5 by the subcutaneous administration of testosterone propionate injection in olive oil for 28 consecutive days.Results: The BPH control indicated significantly (p <0.05) increases in prostate weight, prostate index, serum testosterone (TT), dihydrotestosterone (DHT) and estradiol (E2) concentrations relative to the normal control. Treatment with CEAA caused dose-dependent significant (p <0.05) decreases in the prostate weight, prostate index, TT, DHT and E2 similar to finasteride-treated BPH induced rats when compared with BPH control rats. The CEAA had high inhibitory effects on the prostate weight (55.71 -82.86 %) and prostate index (65.33 – 86.52 %) of the BPH induced rats greater than 71.52 % and 81.63 % inhibition of prostate weight and prostate index by finasteride, respectively.Recommended applications/industries: The findings of this study indicated that combined ethanol extract of A. vogelii and A. boonei stem barks has anti-benign prostatic hyperplasia activities as it down-regulated the serum concentrations of TT, DHT and E2 implicated in BPH development and progression تفاصيل المقالة
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  3 - Combined ethanol extract of Spermacoce radiata and Hypselodelphyspoggeana prevents renal damage and dyslipidemia in benign prostatic hyperplasia induced rats
  رابرت اورکو پوول آنیام امانوئل اویو اوبینا آجا
  10.30495/medherb.2021.688096
  Background & Aim: A combined ethanol extract of Spermacoce radiata and Hypselodelphyspoggeana leaves are used for the treatment of benign prostatic hyperplasia, but there is no scientific data on its safety level and effects on vital organs and biochemical parameter أکثر

  Background & Aim: A combined ethanol extract of Spermacoce radiata and Hypselodelphyspoggeana leaves are used for the treatment of benign prostatic hyperplasia, but there is no scientific data on its safety level and effects on vital organs and biochemical parameters. This study investigated the effects of a combined ethanol extract of Spermacoce radiata and Hypselodelphyspoggeana leaves (CESHL) on the lipid profile and kidney function of benign prostatic hyperplasia (BPH) induced rats.Experimental: A total of 21 rats were used for the acute toxicity study, while 30 were randomly distributed into five groups comprising six rats each (n = 6) for the BPH study. Group 1 served as normal control, while group 2 was BPH control that received 5 mg/kg of testosterone propionate/day for 28 consecutive days without treatment. Groups 3 – 5 received 5 mg/kg of testosterone propionate/day for 28 days but after an hour, they treated with 5 mg/kg of finasteride, 200 and 600mg/kg of CESHL/day, respectively, for 28 days.Results: The acute toxicity result of CESHL indicated no mortality or any sign of toxicity. Administration of the extract caused a significant reduction (p<0.05) of theprostate weight, triacylglycerol, cholesterol, low-density lipoprotein (LDL-C), urea and creatinine concentrations in the treated groups when compared to the BPH control. A significant increase (P<0.05) in High-Density Lipoprotein (HDL) concentration was observed in all treated groups when compared to the BPH control group. Histological outcomes of rats’ kidneys corroborated these findings.Recommended applications/industries: These results indicate that the combined extracts possess antilipidemic and nephroprotective effects, which might help in the management of complications that might arise during BPH. تفاصيل المقالة