فهرس المقالات Hemophilia

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  1 - <i>In vivo</i> evaluation of <i>Polygonum bistorta</i> extract effect on blood coagulation factors
  Marzieh Moiedie Jafar Vatandoost Toktam Hajjar Behnam Mahdavi
  10.30495/tpr.2023.1976011.1312
  Polygonum bistorta contains phytochemical compounds that can affect coagulation. It is used as hemorrhoid for bleeding control in traditional medicine. For its in vivo evaluation, 35 mice were randomly divided into 5 groups (n = 7) as well as the negative and positive c أکثر

  Polygonum bistorta contains phytochemical compounds that can affect coagulation. It is used as hemorrhoid for bleeding control in traditional medicine. For its in vivo evaluation, 35 mice were randomly divided into 5 groups (n = 7) as well as the negative and positive control. On the 13th day of treatment, blood samples were collected for bleeding time (BT), clotting time (CT) and the number of platelets and on the 14th day, for prothrombin time (PT), activated partial thromboplastin time (aPTT). The results were shown although P. bistorta extract had a significant reducing effect on all coagulation tests in a dose-dependent manner, the greatest reduction in coagulation time (16.5 times) in the CT test and the best significant dosage is 1000 mg/kg/day shows that the P. bistorta extract has a greater effect on the common pathway than intrinsic and extrinsic pathways. تفاصيل المقالة
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  2 - Blood coagulation effect of combined extract of Thymus vulgaris and Medicago sativa
  Zahra Sadat  Mashkani Jafar Vatandoost Toktam  Hajjar Behnam Mahdavi
  Thymus vulgaris and Mediacgo sativa, are used as a traditional remedy in the treatment of bleeding disorders. Considering their probabilistic coagulation compounds, in an animal study, forty male mice were randomly divided into 5 groups (n = 8) as well as negative and أکثر

  Thymus vulgaris and Mediacgo sativa, are used as a traditional remedy in the treatment of bleeding disorders. Considering their probabilistic coagulation compounds, in an animal study, forty male mice were randomly divided into 5 groups (n = 8) as well as negative and positive control. Coagulation indices include bleeding time (BT), clotting time (CT), and the number of platelets (PLT) were examined on the 13th day of treatment. A significant reduction in the BT and CT tests, as well as a significant increase in PLT in the treated groups was observed. It is concluded that although the T. vulgaris and M. sativa extracts have a coagulation effect through primary homeostasis and a common pathway of secondary hemostasis, combined extracts are more effective than individual extracts. Moreover, phenolic and flavonoid compounds are the most affecting compounds that affect platelet number and aggregation. تفاصيل المقالة
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  3 - Frequency of Iron Deficiency and Iron Deficiency Anemia among Hemophilia Children in Babylon Hereditary Blood Disease Center /Iraq
  Ahmed Shemran Mutlaq Al-Wataify Hussain Naji Al-Shammary Amna Ganem Abdul-hussain Qasim Fakher Alhussainy
  10.22034/jchr.2022.688197
  Objective: to evaluate the frequency of iron deficiency with or without anemia among hemophilia patients with its correlation with other factors including age, address, type and severity of hemophilia. Study design: Cross sectional study, it was conducted at Babylon her أکثر

  Objective: to evaluate the frequency of iron deficiency with or without anemia among hemophilia patients with its correlation with other factors including age, address, type and severity of hemophilia. Study design: Cross sectional study, it was conducted at Babylon hereditary blood disease center at Babylon Government/Iraq. For a period of 10 months, from 1st of February to end of November 2019. Methods: The study included 60 patients of hemophilia classified into: hemophilia A (40) patients and hemophilia B (20) patients; all of them were males; age ranged from 6 months to 15 years. All patients were sent for white blood cells count, Hb, Red blood cells indices, serum ferritin level, ESR, C-reactive protein and virology screening. Results: The study reveals IDA occurred in 28.3% and 58.3% of patients developed ID. There was more declined in mean ferritin level among patients with IDA reached 3.7 &plusmn; 1.4 ng ml-1 , compared to 5.7&plusmn; 1.4 ng ml-1 in ID and in those with sever deficiency. Higher percentage of ID and IDA occurred in complicated hemophilia and those were lived in rural areas. Conclusion: Iron deficiency and IDA are common among hemophilia patients. تفاصيل المقالة