فهرس المقالات Citrus paradisi

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  1 - Toxicological assessment of ethanol seed extract of Citrus paradisi Macfad (grapefruit) on oxidative status, organ function and histoarchitecture in Wistar rats
  گودویل اودوم اومینی یمیتان دانیال اوبوت جون ادوبانگ نکچی اونیکو امانوئل ابانگو ساندی سویمی
  10.30495/medherb.2021.681956
  Background & Aim:Citrus paradisi Macfad (Rutaceae) seed extract (CPE) is used in folkloric medicine for the management of diabetes, blood deficiencies and as immune booster, which may require long term usage. This study aimed to evaluate the toxicity profile of etha أکثر

  Background & Aim:Citrus paradisi Macfad (Rutaceae) seed extract (CPE) is used in folkloric medicine for the management of diabetes, blood deficiencies and as immune booster, which may require long term usage. This study aimed to evaluate the toxicity profile of ethanol seed extract of grapefruit in adult Wistar rats in order to determine its safety profile in whole organism’s systems.Experimental: Acute toxicity study was conducted using OECD–425 procedure. Subchronic toxicity study (90 days) was conducted using 40 adult male Wistar rats, randomly divided into four groups (10/group) and orally-treated daily, thus: Group I-Control (normal saline, 10 ml/kg), Groups II-IV received CPE (4, 40 and 400) mg/kg body weight, respectively. On the 92nd day, animals (6/group) were euthanized under diethyl ether anaesthesia and sacrificed. Vital organs were eviscerated, blotted, weighed and stored for oxidative stress measurement; some samples of the organs were fixed in formalin for histopathological examination. Other animals (4/group) were retained for reversibility studies.Results: Results showed significant increase and decrease in weights of the kidneys and spleen, respectively. Significant increase in malondialdehyde level and decreases in superoxide dismutase, glutathione and catalase activities were recorded. Histopathology of the kidney, liver, and lungs showed some degree of pathologies. Reversibility studies showed reversal of test effects on extract discontinuation. Despite the diverse biological usefulness of ethanol seed extract of C. paradisi (CPE), it may also induce an array of toxicities especially on long term use.Recommended applications/industries: Contrary to the tradomedical claims that CPE is absolutely safe, the study revealed that CPE may induce oxidative stress and organ toxicity especially on long term use. It is imperative the plant seed extract and its derivatives be used with utmost caution, and where possible be avoided. تفاصيل المقالة
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  2 - Hepatoprotective Properties of Ethanol Seed Extract of Citrus paradisi Macfad (Grape Fruit) Against Paracetamol-Induced Hepatotoxicity in Wistar Rats
  گادویل جی اودوم اومونیی کا یمیتان امم ای اومو اچ. او. سی ماگوو اکمینی ای یوکپه پول اس. توماس
  10.14196/JHD. 2018. 219
  Background & Aim: The human body has the liver as one of its largest organs. It serves as the major site for metabolism and excretion. Injury to the liver or impairment of its functions may complicate one’s health and therefore, constitutes one of the serious أکثر

  Background & Aim: The human body has the liver as one of its largest organs. It serves as the major site for metabolism and excretion. Injury to the liver or impairment of its functions may complicate one’s health and therefore, constitutes one of the serious public health challenges. The ethanol seed extract of Citrus paradisi Macfad (CPE) was carried out to evaluate its protective usefulness on the liver against paracematol-induced liver injury. Experimental: Thirty adult male Wistar rats were randomly allotted to five groups (6/group) and orally-treated daily with 100 mg/kg body weight of silymarin (positive Control), 10 ml/kg body weight of distilled water (negative control) and CPE (200, 400 and 600 mg/kg) body weight, respectively for 7 days. On the eighth day, all groups were administered 2 g/kg body weight of paracetamol. 24 h thereafter, animals were sacrificed under diethyl ether anesthesia and blood samples were collected by cardiac puncture for biochemical and haematological investigations. Results: Compared to the negative control, extract (200 – 600 mg/kg) significantly (p<0.05)reduced the activities of ALP, ALT and AST dose-dependently. Extract significantly (p<0.05) elevated all blood parameters except for neutrophil differentials. Recommended applications/industries: Grapefruit seed extract possesses hepatoprotective potential and can be used as an antidote against paracetamol-induced hepatotoxicity. تفاصيل المقالة