فهرس المقالات Biological application

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  • صفحة الملخص
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  1 - Exploring the cytotoxicity of CeO2 nanoparticles: A compendious approach
  Zahra Yaghoobi Vishnu Sankar Nooshin Amini Abbas Rahdar
  10.22034/jna.2020.1879379.1160
  Metal oxide nanoparticles due to their antioxidant properties have attracted significant attention and exhibited good potential for use in cancer theranostics. Owing to the poor absorption in the physiological environment, they are an ideal candidate to act as nanocarri أکثر

  Metal oxide nanoparticles due to their antioxidant properties have attracted significant attention and exhibited good potential for use in cancer theranostics. Owing to the poor absorption in the physiological environment, they are an ideal candidate to act as nanocarriers in targeted drug delivery and bioimaging. This feature can be successfully implemented in live monitoring and imaging applications, which offer the possibilities and scope for optical, magnetic resonance, and nuclear imaging. The environment of malignant cells like the rapid proliferation of cells, specific antigen expressions, and leaky tumor vasculature can be used by the modifications in their morphology and surface functionalization. Ceria (CeO2) nanoparticles have been fascinating in this regard. Different properties such as size, agglomeration behavior, and surface charge density facilitate the interaction of nanoparticles with cancer cells. Compared to other nanoparticles, CeO2 nanoparticles have a potential for pharmaceutical use since they can act as a therapeutic agent in different disorders such as cancer, inflammation, and neurodegeneration, due to the ability to exhibit variable oxidation state at the nanoparticle surface. Recent literature reports the eco-friendly or ‘green’ synthesis of CeO2 nanoparticles in which the biological agent acts as stabilizers for a cost-effective and feasible mode of preparation. In this review, we focus on recent literature on CeO2 nanoparticles with an emphasis on the methods of fabrication and biomedical applications. تفاصيل المقالة
• حرية الوصول المقاله
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  2 - Biological application of Layered double hydroxides in drug delivery systems
  nahid shahabadi Mahtab Razlansari
  10.22034/jna.2018.567196.1088
  This review focuses on the extensive study of different layer double hydroxides (LDHs) nanostructures and also their biological and physicochemical (in vitro) properties to encapsulate and deliver drugs with a recognized pharmacokinetic profile in a sustained/modified m أکثر

  This review focuses on the extensive study of different layer double hydroxides (LDHs) nanostructures and also their biological and physicochemical (in vitro) properties to encapsulate and deliver drugs with a recognized pharmacokinetic profile in a sustained/modified manner for better remedial efficacy contrasted to the corresponding conventional treatments using free drugs. LDHs known as hydrotalcite like compounds possess positive charges due to isomorphic substitutions, which are counterbalanced by hydrated exchangeable anions located in the interlayer region. Some of the active ingredient molecules can be intercalated into the inner region of the LDHs through ionic bonding, hydrogen bonding or van der Waals interaction to form nanohybrids, which are more potent for their protection and controlled‐release. In addition, this composite material exhibits a selective release toward cancer cells and good biocompatibility with normal cells, which would guarantee its practical applications in cancer therapy.Development of new pharmaceutical formulations is observed, based on LDHs, for cancer therapy. تفاصيل المقالة
• حرية الوصول المقاله
  • صفحة الملخص
  • نص كامل
  
  3 - Exploring the cytotoxicity of CeO2 nanoparticles: A compendious approach
  Zahra Yaghoobi Abbas Rahdar Vishnu Sankar Nooshin Amini
  10.22034/jna.2020.677349
  Metal oxide nanoparticles due to their antioxidant properties have attractedsignificant attention and exhibited good potential for use in cancer theranostics.Owing to the poor absorption in the physiological environment, they are anideal candidate to act as nanocarriers أکثر

  Metal oxide nanoparticles due to their antioxidant properties have attractedsignificant attention and exhibited good potential for use in cancer theranostics.Owing to the poor absorption in the physiological environment, they are anideal candidate to act as nanocarriers in targeted drug delivery and bioimaging.This feature can be successfully implemented in live monitoring and imagingapplications, which offer the possibilities and scope for optical, magneticresonance, and nuclear imaging. The environment of malignant cells likethe rapid proliferation of cells, specific antigen expressions, and leaky tumorvasculature can be used by the modifications in their morphology and surfacefunctionalization. Ceria (CeO2) nanoparticles have been fascinating in this regard.Different properties such as size, agglomeration behavior, and surface chargedensity facilitate the interaction of nanoparticles with cancer cells. Compared toother nanoparticles, CeO2 nanoparticles have a potential for pharmaceutical usesince they can act as a therapeutic agent in different disorders such as cancer,inflammation, and neurodegeneration, due to the ability to exhibit variableoxidation state at the nanoparticle surface. Recent literature reports the ecofriendlyor ‘green’ synthesis of CeO2 nanoparticles in which the biological agentacts as stabilizers for a cost-effective and feasible mode of preparation. In thisreview, we focus on recent literature on CeO2 nanoparticles with an emphasis onthe methods of fabrication and biomedical applications. تفاصيل المقالة
• حرية الوصول المقاله
  • صفحة الملخص
  • نص كامل
  
  4 - Biological Application of Layered Double Hydroxides in Drug Delivery Systems
  Nahid Shahabadi Mahtab Razlansari
  10.22034/jna.2018.545418
  This review focuses on the extensive study of different layered double hydroxides (LDHs)nanostructures and also their biological and physicochemical (in vitro) properties to encapsulateand deliver drugs with a recognized pharmacokinetic profile in a sustained/modified m أکثر

  This review focuses on the extensive study of different layered double hydroxides (LDHs)nanostructures and also their biological and physicochemical (in vitro) properties to encapsulateand deliver drugs with a recognized pharmacokinetic profile in a sustained/modified manner forbetter remedial efficacy contrasted to the corresponding conventional treatments using differentdrugs. LDHs known as hydrotalcite like compounds possess positive charges due to isomorphicsubstitutions, which are counterbalanced by hydrated exchangeable anions located in the interlayerregion. Some of the active ingredient molecules can be intercalated into the inner region of the LDHsthrough ionic bonding, hydrogen bonding or van der Waals interaction to form nanohybrids, whichare more potent for their protection and controlled‐release. In addition, this composite materialexhibits a selective release toward cancer cells and good biocompatibility with normal cells, whichwould guarantee its practical applications in cancer therapy. تفاصيل المقالة