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حرية الوصول المقاله
1 - Applying Kinetic Spectrophotometric Method for Megestrol Drug with Albizia Lebbeck Leaves-capped AgNPs Sensor Synthesis in Urine and Blood Samples
leila niknam Farzaneh MarahelMegestrol drug is a synthetic steroid progesterone, and it is used as an anti-plasma agent to treat advanced breast cancer or endometriosis. Although the liquid chromatographic method for measuring megestrol has advantages such as excellent accuracy and reproducibility, أکثرMegestrol drug is a synthetic steroid progesterone, and it is used as an anti-plasma agent to treat advanced breast cancer or endometriosis. Although the liquid chromatographic method for measuring megestrol has advantages such as excellent accuracy and reproducibility, it has limitations such as long-time measure, high equipment cost, and maintenance and use. In this study, for determination of megestrol drug in solution using kinetic spectrophotometric method, we prepared a solution of Albizia Lebbeck Leaves-capped AgNPs utilizing sodium borohydride as a stabilizer sensor. The calibration curve was linear in the range of (0.1 to 10.0 µg L−1). The standard deviation of (3.0%), and detection limit of the method (0.2 µg L−1 in time 7 min, 385 nm) were obtained for Sensor level response Albizia Lebbeck Leaves-capped AgNPs with (95%) confidence evaluated. The observed outcomes confirmed the suitability recovery and a very low detection limit for measuring the megestrol drug. The method introduced to measure megestrol drug in real samples such as urine and blood was used and can be used for hospital samples. The chemical Albizia Lebbeck Leaves-capped AgNPs sensor made it possible as an excellent sensor with reproducibility. تفاصيل المقالة -
حرية الوصول المقاله
2 - Design and Evaluation an Origanum majorana-Capped AgNPs Sensor: Determination of Trace Megestrol Drug in Urine and Blood Samples using Kinetic Spectrophotometric Method
Zahra Kazemi Farzaneh Marahel Touba Hamoule Bijan Mombeni GoodajdarMegestrol drug is a synthetic steroid progesterone, and it is used as an anti-plasma agent to treat advanced breast cancer or endometriosis. In this study, for determination of megestrol drug in solution using kinetic spectrophotometric method, we prepared a solution of أکثرMegestrol drug is a synthetic steroid progesterone, and it is used as an anti-plasma agent to treat advanced breast cancer or endometriosis. In this study, for determination of megestrol drug in solution using kinetic spectrophotometric method, we prepared a solution of Origanum majoranacapped AgNPs utilizing sodium borohydride as a stabilizer sensor. The calibration curve was linear in the range of (0.01 to 10.0 µg L−1). The standard deviation of (1.8%), and detection limit of the method (0.023 µg L−1 in time 8 min, 345 nm) were obtained for Sensor level response Origanum majorana-capped AgNPs with (95%) confidence evaluated. The observed outcomes confirmed the suitability recovery and a very low detection limit for measuring the megestrol drug. The method introduced to measure megestrol drug in real samples such as urine and blood was used and can be used for other drugs and hospital samples. تفاصيل المقالة -
حرية الوصول المقاله
3 - Green Fabrication of Albizia Lebbeck Leaves-Capped Silver Nanoparticles for Removal of Butylparaben
Fatemeh Maghami Maryam Abrishamkar Bijan Mombini Godajdar Mina HossieniAlbizia Lebbeck Leaves-Capped Silver Nanoparticles (ALLC AgNPs) were constructedusing a green and sustainable method and used as an effective adsorbent for the removal ofbutylparaben (BP) dye from an aqueous solution. The possible mechanisms for thefabrication of ALLC A أکثرAlbizia Lebbeck Leaves-Capped Silver Nanoparticles (ALLC AgNPs) were constructedusing a green and sustainable method and used as an effective adsorbent for the removal ofbutylparaben (BP) dye from an aqueous solution. The possible mechanisms for thefabrication of ALLC AgNPs were also investigated and discussed. The proposed adsorbentwas characterized and identified using FT-IR, XRD, and SEM techniques. For investigatingthe influence of affective factors like BP dye concentration, pH, adsorbent dosage, andsonication time on the removal process and achieving optimum conditions, central compositedesign (CCD) based response surface methodology (RSM) was applied. To investigate theadsorption mechanism and kinetic of the removal reaction, different isotherm and kineticmodels were used. The obtained results proved the applicability of fabricated adsorbent as anideal material for the treatment of pollutants and especially dye molecules. تفاصيل المقالة -
حرية الوصول المقاله
4 - Preclinical Evaluation of Silver-Curcumin Nanogel: A complete Assessment on a New Topical Antimicrobial Formulation for Burn Healing
Sepideh Arbabi BidgoliNanosilver and nanocurcumin are popular nonmaterial with increasing public attention but their synergistic therapeutic potentials in burns have never been considered. Present study aimed to provide a novel formulation from both nanomaterials (Ag – Curcumin NPs) and cond أکثرNanosilver and nanocurcumin are popular nonmaterial with increasing public attention but their synergistic therapeutic potentials in burns have never been considered. Present study aimed to provide a novel formulation from both nanomaterials (Ag – Curcumin NPs) and conduct their preclinical evaluation for burn healing. After evaluation of particle size, loading efficiency, release profile and morphology of manufactured nanoparticles by TEM and DLS techniques , a 14 days skin irritation and corrosion test on Albino rabbits was performed based on OECD 404 guideline . Ames Mutagenicity test was performed on 4 strains of Salmonella Typhymurium after MIC and MBC adjustments in different doses. For clinical efficacy, skin burn model was designed and applied in rats by providing limited standard 3rd degree burns at the back of each rabbit. Manufacture lyophilized spherical nanoparticles in the range of 20- 38 nm, with low zeta potential didn't show any significant size enlargement. The nanogel was also considered as a nonirritant and non-corrosive formulation after short term and long term dermal applications (>72 hrs.) .No mutagenic effects were also identified in all strains in the test samples of Ag - Curcumin NPs (Mutation Index=0.08-0.27). This study clearly showed the safety of Ag – Curcumin NPs nanogel in low concentrations with small dimension (16-32µg/ml). Due to the safety of proposed formulation and increased rate of wound healing by Ag- Curcumin nanogel in comparison to both control groups, this combinational formulation could be considered as a safe and effective candidate for further clinical applications. تفاصيل المقالة -
حرية الوصول المقاله
5 - Preclinical Evaluation of Silver-Curcumin Nano- gel : A complete assessment on a new topical antimicrobial product for burn
Monir Aghamoosa Sepideh Arbabi-Bidgoli Solmaz Ghafari Azar Sabokbar Naser HarzandiNanosilver and nanocurcumin are popular nonmaterial with increasing public attention, but their synergistic therapeutic potentials in burns have never been considered. The present study aimed to provide a novel formulation from both nanomaterials (Ag – Curcumin NP أکثرNanosilver and nanocurcumin are popular nonmaterial with increasing public attention, but their synergistic therapeutic potentials in burns have never been considered. The present study aimed to provide a novel formulation from both nanomaterials (Ag – Curcumin NPs) and conduct their preclinical evaluation for burn healing. After evaluation of particle size, loading efficiency, release profile and morphology of manufactured nanoparticles by TEM and DLS techniques , a 14 days skin irritation and corrosion test on Albino rabbits was performed based on OECD 404 guideline . The Ames Mutagenicity test was performed on 4 strains of Salmonella Typhymurium after MIC and MBC adjustments indifferent doses. For clinical efficacy, skin burn model was designed and applied in rats by providing limited standard 3rd degree burns at the back of each rabbit. Manufacture lyophilized spherical nanoparticles in the range of 20- 38 nm, with low zeta potential didn't show any significant size enlargement. The nanogel was also considered as a nonirritant and non-corrosive formulation after short term and long term dermal applications (>72 hrs.) .No mutagenic effects were also identified in all strains in the test samples of Ag - Curcumin NPs (Mutation Index=0.08-0.27). This study clearly showed the safety of Ag – Curcumin NPs nanogel in low concentrations with small dimension (16-32μg/ml). Due to the safety of proposed formulation and increased rate of wound healing by Ag-Curcumin nanogel in comparison to both control groups, this combinational formulation could be considered as a safe and effective candidate for further clinical applications. تفاصيل المقالة -
حرية الوصول المقاله
6 - بررسی اثرات کاربرد توام اسکوپولتین و نانوذرات نقره سنتز شده به روش سبز بررگ زایی در مدل پرده کوریوآلانتوئیک جنین جوجه
پریسا زمانی عصمتی جواد بهارآرا علیرضا ایرانبخش طیبه رمضانیامروزه خواص ضد رگزایی فرآورده های گیاهی مورد توجه محققان قرار دارد. نانو ذرات نقره (AgNPs) سنتز شده به روش سبز و اسکوپولتین دارای خواص ضد رگزایی هستند. در مطالعه حاضر کاربرد توام این دو ماده بر رگ زایی در پرده کوریوآلانتوئیک جنین جوجه بررسی گردید.در این پژوهش تجربی آزما أکثرامروزه خواص ضد رگزایی فرآورده های گیاهی مورد توجه محققان قرار دارد. نانو ذرات نقره (AgNPs) سنتز شده به روش سبز و اسکوپولتین دارای خواص ضد رگزایی هستند. در مطالعه حاضر کاربرد توام این دو ماده بر رگ زایی در پرده کوریوآلانتوئیک جنین جوجه بررسی گردید.در این پژوهش تجربی آزمایشگاهی تخم مرغ های نطفه دار به گروه شاهد و گروه های تجربی شامل نمونه های تیمار شده با نانو ذرات نقره (µg/ml100،50و150)، اسکوپولتین (µg/ml25، 50 و100)، گروه هم افزایی شامل µg/ml50 نانو ذرات نقره و .µg/ml25 اسکوپولتین تقسیم شدند. روز هشتم انکوباسیون تیمار بر روی اسفنج ژلاتینی انجام شد و روز دوازدهم پس ازعکس برداری، تعداد و طول انشعابات عروقی، طول فرق سری-نشیمنگاهی ،وزن جنین ها و سطح هموگلوبین عروق خونی ثبت و با شاهد مقایسه گردید. داده ها توسط نرم افزار 16SPSS -، آزمون های واریانس یک طرفه ANOVA و آزمون تعقیبیTukey در سطح معنی داری. P>0/05تجزیه و تحلیل گردید.یافته ها نشان داد نانو ذارت نقره و اسکوپولتین، وابسته به دوز منجر به کاهش تعداد و طول عروق خونی و سطح غلظت هموگلوبین خون در نمونه های تیماری می شود. بکارگیری توام غلظت های µg/ml50 نانو ذرات نقره و غلظتµg/ml 25 اسکوپولتین که بر روند آنژیوژنز بی تاثیر بودند، کاهش معنی دار رگ زایی را نشان دادند (P>0/05).بکارگیری توام نانوذرات نقره و اسکوپولتین باعث تقویت اثر ضد رگزایی آنها شده و می تواند به عنوان یک زمینه مطالعاتی مهم جهت شناسایی راه های درمانی موثر مورد توجه قرار گیرد. تفاصيل المقالة -
حرية الوصول المقاله
7 - سنتز سبز نانوذرات نقره با استفاده از عصاره گیاه گل آرونه و پوست هسته هلو بهعنوان یک بستر با ارزش طبیعی: بررسی فعالیت کاتالیستی برای کاهش متیلن بلو و ردآمین B
بهار خدادادیدر این پژوهش، عصاره گیاه گل آرونه برای سنتز سبز نانوذرات نقره (AgNPs) بر بستر پوست هسته هلو بهعنوان یک بستر مفید و سازگاربامحیطزیست استفاده شده است. نانوذرات نقره جایگزین شده بر پوست هسته هلو، (AgNPs/P.K.shell)، بهعنوان یک کاتالیست مؤثر با کاهش یونهای +Ag به کمک عصا أکثردر این پژوهش، عصاره گیاه گل آرونه برای سنتز سبز نانوذرات نقره (AgNPs) بر بستر پوست هسته هلو بهعنوان یک بستر مفید و سازگاربامحیطزیست استفاده شده است. نانوذرات نقره جایگزین شده بر پوست هسته هلو، (AgNPs/P.K.shell)، بهعنوان یک کاتالیست مؤثر با کاهش یونهای +Ag به کمک عصاره گیاه گل آرونه و جایگزینی آنها بر بستر پوست هسته هلو سنتز شد. بر اساس نتایج FT-IR وجود گروههای هیدروکسیل ترکیبات فنلی در عصاره گیاه گل آرونه، کاهش یونهای +Ag را توجیه میکند. همچنین، کاتالیست سنتز شده با روشهای متفاوت از جمله طیفسنجی مرئی-فرابنفش (UV-Vis)، طیفسنجی فروسرخ تبدیل فوریه (FT-IR)، میکروسکوپ الکترونی روبشی گسیل میدانی (FE-SEM)، طیفسنجی تفکیک انرژی (EDS)، پراش پرتو ایکس (XRD) و میکروسکوپ الکترونی عبوری (TEM) بررسی شد. افزون بر آن، کاتالیست سنتز شده برای کاهش متیلن بلو (MB) و ردآمینBا(RhB) بهکار گرفته شد. نتایج نشان داد که کاتالیست AgNPs/P.K.shell سنتز شده فعالیت کاتالیستی بسیار خوبی در تخریب رنگهای آلی استفادهشده دارد. نتایج نشان داد که کاتالیست سنتز شده قابلیت بازیابی و استفاده دوباره را برای چندین مرتبه بدون کاهش چشمگیر در فعالیت فوتوکاتالیستی دارد. تفاصيل المقالة -
حرية الوصول المقاله
8 - Oxidative Stress Responses and Toxicity of Green Synthesized Silver Nanoparticles (AgNPs) on Basil (Ocimum basilicum) Seedlings
Ali Zareii Hossein Abbaspour Maryam Peyvandi Ahmad MajdThis study aimed at investigating how treatment of basil seedlings with green synthesized AgNPs affects their Ag content, oxidative damage and antioxidant enzymes activity. This research was studied as a completely randomized design in four replications. Four levels of أکثرThis study aimed at investigating how treatment of basil seedlings with green synthesized AgNPs affects their Ag content, oxidative damage and antioxidant enzymes activity. This research was studied as a completely randomized design in four replications. Four levels of silver nanoparticles (0, 4, 10 and 40 mg L-1) were used. After germination, the seedlings were treated for 7 days and then seedlings were harvested for analysis. Findings showed that AgNP treatment increased Ag content O2•−, H2O2, MDA, and ion leakage in basil seedlings. The use of AgNPs caused a significant increase in the activities of SOD, APX, CAT, and GR enzymes in plants. However, at high levels (40 mg L-1) of AgNPs, enzymes activity decreased significantly. These findings suggest that the application of green synthesized AgNPs to basil seedlings led to oxidative stress. Moreover, the observed changes in radical scavenging enzyme activity indicate that synthetic green nanoparticles have a harmful effect on basil seedlings. This toxicity is more pronounced at higher concentrations. تفاصيل المقالة
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