Effect of Protein Corona Formation on Photonic Response of Upconverting Nanoparticles

الموضوعات :

Nahid Ghazyani ¹ , Mohammad Hossien Majles Ara ²

1 - Faculty of Physics, Kharazmi University, Tehran, Iran
2 - 1. Department of physics, Kharazmi University, Tehran, Iran. 2. Applied Sciences Research Center, Kharazmi University, Karaj, Iran.

تاريخ الإرسال : 16 السبت , شوال, 1444 تاريخ التأكيد : 02 الأحد , ربيع الأول, 1445 تاريخ الإصدار : 07 الجمعة , ربيع الأول, 1445

الکلمات المفتاحية: Nonlinear photoresponse, Upconversion Nanoparticles, Protein Corona, Corona Formation, human blood plasma, near infrared,

ملخص المقالة :

NaYF4:Yb,Er is one of the efficient and well-known upconverting materials which emit photoluminescence light at 545 nm and 660 nm under an excitation of 980 nm. In this study, up-conversion nanoparticles using thermal decomposition method have been synthesized and characterized and phase transition from organic to aquas by synthesis a SiO2 shell have done successfully. The results show that the nonlinearity response of NaYF4: Yb, Er@SiO2 is same as NaYF4: Yb, Er and SiO2 has no effect on emission peaks it means that these nanoparticles are suitable for biomedical applications. Since it is necessary to know the photoluminescent behavior of UCNPs@SiO2 particles, thereby the fluorescence properties of up-conversion nanoparticles with SiO2 shell have been investigated in PBS, normal and cancerous human blood plasma. The results indicate that UCNP@SiO2 can be applicable in biological medias for therapy and diagnostic.

المصادر:

• Markus, and H. Schäfer, "Upconverting nanoparticles," Angewandte Chemie International Edition, vol. 50, pp. 5808-5829, 2011.


• Bing and F. Wang, "Emerging frontiers of upconversion nanoparticles," Trends in Chemistry, vol. 2, pp. 427-439, 2020.


• Wang, D. Banerjee, Y. Liu, X. Chen, and X. Liu, "Upconversion nanoparticles in biological labeling, imaging, and therapy," Analyst, vol. 135, pp. 1839-1854, 2010.


• Bin and Q. Zhang. "Recent advances on functionalized upconversion nanoparticles for detection of small molecules and ions in biosystems," Advanced Science, vol. 5, pp. 1700609, 2018.


• Gungun and D. Jin, "Responsive sensors of upconversion nanoparticles," ACS sensors, vol. 6, pp. 4272-4282, 2021.


• Kakavelakis, K. Petridis, and E. Kymakis, "Recent advances in plasmonic metal and rare-earth-element upconversion nanoparticle doped perovskite solar cells," Journal of Materials Chemistry A, vol. 5, pp. 21604-21624, 2017.


• A. Ansari and M. Sillanpää, "Advancement in upconversion nanoparticles based NIR-driven photocatalysts," Renewable and Sustainable Energy Reviews, vol. 151, pp. 111631, 2021.


• Wen, J. Zhou, K. Zheng, A. Bednarkiewicz, X. Liu, and D. Jin, "Advances in highly doped upconversion nanoparticles," Nature communications, vol. 9, pp. 2415 (1-12), 2018.


• R. Blanca and D. Jaque, "Upconversion nanoparticles for in vivo applications: limitations and future perspectives," Methods and Applications in Fluorescence, vol. 7, pp. 022001, 2019.


• Andreas and H. H. Gorris, "Surface modification and characterization of photon-upconverting nanoparticles for bioanalytical applications," Chemical Society Reviews, vol. 44, pp.1526-1560, 2015.


• A. Ansari, A. K. Parchur, and G. Chen, "Surface modified lanthanide upconversion nanoparticles for drug delivery, cellular uptake mechanism, and current challenges in NIR-driven therapies," Coordination Chemistry Reviews, vol. 457, pp. 214423, 2022.


• S. Arai and A. SS de Camargo, "Exploring the use of upconversion nanoparticles in chemical and biological sensors: from surface modifications to point-of-care devices," Nanoscale Advances, vol. 3, pp. 5135-5165, 2021.


• -N. Liu, W.-B. Bu, and J.-L. Shi, "Silica coated upconversion nanoparticles: a versatile platform for the development of efficient theranostics." Accounts of chemical research, vol. 48, pp. 1797-1805, 2015.


• Drozd, H. Zhang, I. Goryacheva, S. De Saeger, and N. V Beloglazova, "Silanization of quantum dots: challenges and perspectives," Talanta, vol. 205, pp. 120164, 2019.


• Li, C. Ma, F. Wang, Z. Xi, Z. Wang, Y. Deng, and N. He, "Preparation and biomedical applications of core–shell silica/magnetic nanoparticle composites," Journal of nanoscience and nanotechnology, vol. 12, pp. 2964-2972, 2012.


• Hao, B. Ding, and J. Lin, "Recent progress in upconversion nanomaterials for emerging optical biological applications," Advanced Drug Delivery Reviews, vol. 188, pp. 114414, 2022.


• Ghazyani, M. H. Majles Ara, and M. Raoufi, "Nonlinear photoresponse of NaYF₄: Yb, Er@ NaYF₄ nanocrystals under green CW excitation: a comprehensive study," RSC advances, vol. 10, pp. 25696-25702, 2020.