بررسی تغییرات سرمی هموسیستئین و تروپونین قلبی I در گوسفندان مبتلا به تیلریوز در شهرستان ارومیه
الموضوعات :
کاوه عظیم زاده
1
(استادیار گروه علوم درمانگاهی، واحد ارومیه، دانشگاه آزاد اسلامی، ارومیه، ایران.)
اصغر حسن پور
2
(کارشناس علوم آزمایشگاهی، گروه علوم درمانگاهی، واحد ارومیه، دانشگاه آزاد اسلامی، ارومیه، ایران.)
تاريخ الإرسال : 15 الأحد , شوال, 1438
تاريخ التأكيد : 14 السبت , ربيع الأول, 1439
تاريخ الإصدار : 05 السبت , شعبان, 1439
الکلمات المفتاحية:
گوسفند,
تیلریوز,
هموسیستئین,
تروپونین قلبی I,
ملخص المقالة :
تیلریوز یکی از بیماری های مهم تک یاخته ای در دام های اهلی بوده که نقش مهمی در کاهش تولید (شیر و گوشت) دارد. هدف از مطالعه حاضر، ارزیابی تغییرات سرمی هموسیستئین و تروپونین قلبی I به عنوان شاخص های سرمی آسیب قلبی-عروقی در گوسفندان مبتلا به تیلریوز بر اساس جنس و نژاد در شهرستان ارومیه می باشد. پس از تشخیص تیلریوز بر اساس علایم بالینی و آزمایشگاهی، 30 رأس گوسفند بیمار (15 رأس نژاد قزل و 15 رأس نژاد ماکویی) که از نژاد قزل 8 رأس نر و 7 رأس ماده و در نژاد ماکویی هم همین تعداد در نظر گرفته شد. در ضمن همان تعداد گوسفند سالم (از نظر جنس و نژاد) به عنوان گروه سالم انتخاب شدند. از ورید وداج تمام گروه ها خون گیری به عمل آمد و فراسنجه های فوق الذکر در کلیه نمونه ها مورد سنجش و ارزیابی آماری قرار گرفتند. نتایج حاکی از افزایش معنی دار (05/0>p) در تمام فراسنجه ها در گروه بیمار نسبت به گروه سالم بود. در رابطه با جنس، افزایش معنی دار (05/0>p) در تمام فراسنجه ها در جنس نر نسبت به جنس ماده مشاهده شد و در مورد نژاد نیز اختلاف معنی دار (05/0>p) بین گروه بیمار نژاد ماکویی با سالم و نژاد قزل با سالم در فراسنجه ها مشاهده گردید. در مجموع می توان اظهار داشت که افزایش سطح سرمی هموسیستئین و تروپونین قلبی I در گوسفندان مبتلا به تیلریوز مخصوصاً در جنس نر می تواند هشداری بر لزوم توجه هر چه بیشتر به مقوله مدیریت پیشگیری و درمان در گوسفندان مبتلا به تیلریوز باشد.
المصادر:
Azimzadeh, K. (2017). Ovine theileriosis enhances cardiovascular disease biomarkers in naturally infected sheep (ghezel breed) in West Azerbaijan, Iran. İstanbul Ünivsitesi Veterinary Fakultesi Dergisi, 43(1): 61-66.
Babuin, L. and Jaffe, A.S. (2005). Troponin: the biomarker of choice for the detection of cardiac injury. Canadian Medical Association Journal, 173(10): 1191-1202.
Baghishani, H., Razmi, G.R., Yaghfoori, S. and Ahmadi, A. (2012). Investigation of selected biochemical parameters in sheep naturally infected with theileriosis. Comparative Clinical Pathology, 21(6): 1417-1420.
Col, R. and Uslu, U. (2006). Haematological and coagulation profiles during severe tropical theileriosis in cattle. Turkish Journal of Veterinary and Animal Science, 30: 577-582.
Collinson, P.O. and Gaze, D.C. (2007). Biomarkers of cardiovascular damage and dysfunction– an overview. Heart Lung Circulation, 16(3): 71-82.
Fartashvand, M., Nadalian, M.G., Sakha, M. and Safi, S. (2013). Elevated serum cardiac troponin I in cattle with theileriosis. Journal of Veterinary Internal Medicine, 27(1): 194-199.
Ganguly, P. and Alam, S.F. (2015). Role of homocysteine in the development of cardiovascular disease. Nutrition Journal, 14: 6.
Gill, B.S., Bhattacharyulu, Y. and Kaur, D. (1977). Symptoms and pathology of experimental bovine tropical theileriosis (Theileria annulata infection). Annales De Parasitologie Humaine Et Comparee, 52(6): 597-608.
Hashemi-Fesharaki, R. (1997). Tick-borne diseases of sheep and goats and their related vectors in Iran. Parasitologia, 39(2): 115-117.
Hatazoe, T., Kubota, C., Fujiki, M. and Misumi, K. (2012). Mating behavior increases workload of the heart in thoroughbred stallions. Journal of Veterinary Medicine Science, 74(4): 423-428.
Kimmel, S.E. (2000). Sex and myocardial infarction: An epidemiologic perspective. American Journal of Cardiology, 86(2): 10-13.
Kirbas, A., Baydar E., Kandemir, F.M. and Dorman, E. (2014). Evaluation of serum cardiac troponin I concentration in sheep with acute ruminal lactic acidosis. Veterinarski Arhiv, 84(4): 355-364.
Lai, W.K.C. and Kan, M.Y. (2015). Homocysteine-induced endothelial dysfunction. Annals of Nutrition and Metabolism, 67(1): 1-12.
Lobetti, R., Dvir, E. and Pearson, J. (2002). Cardiac troponins in canine babesiosis. Journal of Veterinary Internal Medicine, 16(1): 63-68.
Nazifi, S., Razavi, S.M., Safi, N. and Rakhshandehroo, E. (2012). Malignant ovine theileriosis: Alterations in the levels of homocysteine, thyroid hormones and serum trace elements. Journal of Bacteriology and Parasitology, 3(7): 1-4.
Nehler, M.R., Talor, L.M. and Porter, J.M. (1997). Homocysteine as a risk factor for atherosclerosis: a review. Journal of Cardiovascular Surgery, 5(6): 559-567.
O'Brien, P.J. (2008). Cardiac troponin is the most effective translational safety biomarker for myocardial injury in cardiotoxicity. Toxicology, 245: 206-218.
Omer, O.H., El-Malik, K.H., Mahmoud, O.M., Haroun, E.M., Hawas, A., Sweeney, D., et al. (2002). Haematological profiles in purebred cattle naturally infected with Theileria annulata in Saudi Arabia. Veterinary Paasitology, 107(1-2): 161-168.
Perna, A.F., Ingrosso, D. and De Santo, N.G. (2003). Homocysteine and oxidative stress. Amino Acids, 25(3-4): 409-417.
Razmi, G.R., Barati, F. and Aslani, M.R. (2009). Prevalence of Theileria annulata in dairy cattle in Mashhad area. Iranian Journal of Veterinary Parasitology, 23(1): 81-83.
Razavi, S.M., Nazifi, S., Hasani, S. and Rakhshandehroo, E. (2015). Bovine tropical theileriosis: effects on the cardiovascular system on the basis of serum analysis. Complementary Clinical Pathology, 24(1): 29-33.
Shahnawaz, S., Ali, M., Aslam, M.A., Fatima, R., Chaudhry, Z.L., Hassan, M.U., et al. (2011). A study on the prevalence of a tick-transmitted pathogen, Theileria annulata, and hematological profile of cattle from Southern Punjab (Pakistan). Parasitology Research, 109(4): 1155-1160.
Soulsby, E.J.L. (1982). Helminths, Arthropods and Protozoa of Domesticated Animals. London: Baillière Tindall, pp: 728-741.
Terada, M., Momozawa, Y., Komano, M., Kusunose, R., Sato F. and Sait, T.R. (2005). Changes in the heart rate and plasma epinephrine and norepinephrine concentrations of the stallion during copulation. Reproductive Medicine and Biology, 4(2): 143-147.
Tunca, R., Sozmen, M., Erdogan, H., Citil, M., Uzlu, E., Ozen, H., et al. (2008). Determination of cardiac troponin I in the blood and heart of calves with foot-and-mouth disease. Journal of Veterinary Diagnosis Investigation. 20(5): 598-605.
Yaghfoori, S., Razmi, G.R., Mohri, M., Taghavi Razavizadeh, A.R. and Movassaghi, A.R. (2016). An experimental ovine Theileriosis: The effect of Theileria lestoquardi infection on cardiovascular system in sheep. Acta Tropica, 161: 55-61.
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Azimzadeh, K. (2017). Ovine theileriosis enhances cardiovascular disease biomarkers in naturally infected sheep (ghezel breed) in West Azerbaijan, Iran. İstanbul Ünivsitesi Veterinary Fakultesi Dergisi, 43(1): 61-66.
Babuin, L. and Jaffe, A.S. (2005). Troponin: the biomarker of choice for the detection of cardiac injury. Canadian Medical Association Journal, 173(10): 1191-1202.
Baghishani, H., Razmi, G.R., Yaghfoori, S. and Ahmadi, A. (2012). Investigation of selected biochemical parameters in sheep naturally infected with theileriosis. Comparative Clinical Pathology, 21(6): 1417-1420.
Col, R. and Uslu, U. (2006). Haematological and coagulation profiles during severe tropical theileriosis in cattle. Turkish Journal of Veterinary and Animal Science, 30: 577-582.
Collinson, P.O. and Gaze, D.C. (2007). Biomarkers of cardiovascular damage and dysfunction– an overview. Heart Lung Circulation, 16(3): 71-82.
Fartashvand, M., Nadalian, M.G., Sakha, M. and Safi, S. (2013). Elevated serum cardiac troponin I in cattle with theileriosis. Journal of Veterinary Internal Medicine, 27(1): 194-199.
Ganguly, P. and Alam, S.F. (2015). Role of homocysteine in the development of cardiovascular disease. Nutrition Journal, 14: 6.
Gill, B.S., Bhattacharyulu, Y. and Kaur, D. (1977). Symptoms and pathology of experimental bovine tropical theileriosis (Theileria annulata infection). Annales De Parasitologie Humaine Et Comparee, 52(6): 597-608.
Hashemi-Fesharaki, R. (1997). Tick-borne diseases of sheep and goats and their related vectors in Iran. Parasitologia, 39(2): 115-117.
Hatazoe, T., Kubota, C., Fujiki, M. and Misumi, K. (2012). Mating behavior increases workload of the heart in thoroughbred stallions. Journal of Veterinary Medicine Science, 74(4): 423-428.
Kimmel, S.E. (2000). Sex and myocardial infarction: An epidemiologic perspective. American Journal of Cardiology, 86(2): 10-13.
Kirbas, A., Baydar E., Kandemir, F.M. and Dorman, E. (2014). Evaluation of serum cardiac troponin I concentration in sheep with acute ruminal lactic acidosis. Veterinarski Arhiv, 84(4): 355-364.
Lai, W.K.C. and Kan, M.Y. (2015). Homocysteine-induced endothelial dysfunction. Annals of Nutrition and Metabolism, 67(1): 1-12.
Lobetti, R., Dvir, E. and Pearson, J. (2002). Cardiac troponins in canine babesiosis. Journal of Veterinary Internal Medicine, 16(1): 63-68.
Nazifi, S., Razavi, S.M., Safi, N. and Rakhshandehroo, E. (2012). Malignant ovine theileriosis: Alterations in the levels of homocysteine, thyroid hormones and serum trace elements. Journal of Bacteriology and Parasitology, 3(7): 1-4.
Nehler, M.R., Talor, L.M. and Porter, J.M. (1997). Homocysteine as a risk factor for atherosclerosis: a review. Journal of Cardiovascular Surgery, 5(6): 559-567.
O'Brien, P.J. (2008). Cardiac troponin is the most effective translational safety biomarker for myocardial injury in cardiotoxicity. Toxicology, 245: 206-218.
Omer, O.H., El-Malik, K.H., Mahmoud, O.M., Haroun, E.M., Hawas, A., Sweeney, D., et al. (2002). Haematological profiles in purebred cattle naturally infected with Theileria annulata in Saudi Arabia. Veterinary Paasitology, 107(1-2): 161-168.
Perna, A.F., Ingrosso, D. and De Santo, N.G. (2003). Homocysteine and oxidative stress. Amino Acids, 25(3-4): 409-417.
Razmi, G.R., Barati, F. and Aslani, M.R. (2009). Prevalence of Theileria annulata in dairy cattle in Mashhad area. Iranian Journal of Veterinary Parasitology, 23(1): 81-83.
Razavi, S.M., Nazifi, S., Hasani, S. and Rakhshandehroo, E. (2015). Bovine tropical theileriosis: effects on the cardiovascular system on the basis of serum analysis. Complementary Clinical Pathology, 24(1): 29-33.
Shahnawaz, S., Ali, M., Aslam, M.A., Fatima, R., Chaudhry, Z.L., Hassan, M.U., et al. (2011). A study on the prevalence of a tick-transmitted pathogen, Theileria annulata, and hematological profile of cattle from Southern Punjab (Pakistan). Parasitology Research, 109(4): 1155-1160.
Soulsby, E.J.L. (1982). Helminths, Arthropods and Protozoa of Domesticated Animals. London: Baillière Tindall, pp: 728-741.
Terada, M., Momozawa, Y., Komano, M., Kusunose, R., Sato F. and Sait, T.R. (2005). Changes in the heart rate and plasma epinephrine and norepinephrine concentrations of the stallion during copulation. Reproductive Medicine and Biology, 4(2): 143-147.
Tunca, R., Sozmen, M., Erdogan, H., Citil, M., Uzlu, E., Ozen, H., et al. (2008). Determination of cardiac troponin I in the blood and heart of calves with foot-and-mouth disease. Journal of Veterinary Diagnosis Investigation. 20(5): 598-605.
Yaghfoori, S., Razmi, G.R., Mohri, M., Taghavi Razavizadeh, A.R. and Movassaghi, A.R. (2016). An experimental ovine Theileriosis: The effect of Theileria lestoquardi infection on cardiovascular system in sheep. Acta Tropica, 161: 55-61.
