خواص، روش‌های سنتز و کاربردهای کورکومین به‌عنوان منبع طبیعی سلامت
الموضوعات : تحقیقات در علوم مهندسی سطح و نانو موادسعیده ابراهیمی اصل 1 , رضا جوانمردی 2 , عاطفه بدر 3
1 - استادیار گروه شیمی، دانشکده علوم پایه، دانشگاه آزاد اسلامی واحد اهر، اهر، ایران
2 - دانشجوی کارشناسی ارشد، دانشکده علوم پایه، دانشگاه آزاد اسلامی واحد اهر، اهر، ایران
3 - دانشجوی دکتری، دانشکده مهندسی مواد، دانشگاه صنعتی سهند، ایران
الکلمات المفتاحية: آلزایمر, زردچوبه, نانوکپسوله, نانو کورکومین, بیولوژیکی, حامل دارویی,
ملخص المقالة :
کورکومین به عنوان مهم‌ترین و فعال‌ترین جزء زردچوبه از داروهای گیاهی است که به جهت تأثیر چشمگیر و گسترده در درمان انواع بیماری‌هایی که بشر با آن‌ها روبه رواست مانند آلزایمر، سرطان، افسردگی، آرتریت و غیره می‌تواند موردمطالعه و تحقیق مجدد قرار گیرد. ازاین‌رو، محققان تلاش کرده‌اند تا با اصلاح سطح، فعالیت بیولوژیکی و دارویی کورکومین را افزایش داده و با سیستم‌های تحویل کارآمد، به‌ویژه نانو کپسوله‌سازی، بر معایب آن غلبه کنند. تلاش‌های تحقیقاتی تاکنون پتانسیل رضایت‌بخشی از فرمول‌های نانو رنگ و نانو داروی کورکومین را نشان داده است که تمام مزایای بیولوژیکی و دارویی کورکومین را افزایش می‌دهد. نانو پزشکی شاخه‌ای است که به کاربردهای نانوتکنولوژی در درمان می‌پردازد. برای سنتز نانو کورکومین، مجموعه‌ای از تکنیک‌ها توسعه‌یافته است و هر تکنیک دارای مزایا و ویژگی‌های منحصربه‌فردی است. روش تخریب فتوشیمیایی کورکومین یکی از موانع برای هدف دارورسانی مؤثر است که باتوجه‌به تغییرات مختلف مولکول کورکومین، از جمله، تهیه کمپلکس‌های فلزی، مشتقات فعال بیولوژیکی بیشتری از این ترکیب را می‌توان به دست آورد. اکسیدهای فلزی آسیب نسبتاً کمتری برای سیستم‌های بیولوژیکی دارند و به‌عنوان حامل دارویی برای کورکومین استفاده می‌شوند که شامل TiO2، CuO، ZnO، Fe3O4 و CeO2 است.
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