کاربرد نانو پلیمرهای زیستی در درمان صدمات قلبی
الموضوعات : تحقیقات در علوم مهندسی سطح و نانو موادبهزاد یثربی 1 , محدثه سیفی 2 , زهرا سلیمان زاده 3 , عاطفه بدر 4
1 - استادیار گروه مهندسی پزشکی، دانشکده فنی مهندسی، دانشگاه آزاد اسلامی تبریز، ایران
2 - دانشجو کارشناسی مهندسی پزشکی، دانشکده فنی مهندسی، دانشگاه آزاد اسلامی، تبریز، ایران
3 - دانشجو کارشناسی مهندسی پزشکی، دانشکده فنی مهندسی، دانشگاه آزاد اسلامی، تبریز، ایران
4 - دانشجوی دکتری، دانشکده مهندسی مواد، دانشگاه صنعتی سهند، تبریز، ایران
الکلمات المفتاحية: زیست سازگاری, حامل دارو, نانو بیومواد, بیماری ایسکمیک قلبی, جریان خون میوکارد,
ملخص المقالة :
بیماری های قلبی عروقی، از جمله بیماری ایسکمیک قلبی و سکته مغزی، مسئول 25 درصد از کل مرگ و میرها در سراسر جهان هستند. در سطح جهانی، علیرغم پیشرفت های عظیم در تشخیص و درمان بیماری های قلبی عروقی، شیوع آنها همچنان در حال افزایش است. برای اهداف درمانی و احیا کننده، استفاده از نانوبیومواد راه حل هایی را ارائه می‌دهد که نسبت به سایر مواد مصنوعی مزایای زیادی دارد. علاوه بر این، دسترسی آسان به‌عنوان فرمول‌های نانو، کاربرد بیومواد را به‌عنوان حامل دارو یا نانوپوسته‌های محافظ توصیه می‌کند که زیست سازگاری عوامل تصویربرداری را بهبود می‌بخشد. به طور مثال در مقایسه با روش‌های سنتی دارورسانی، تحویل نانودارو، لیگاندهای مختلفی را با توجه به مکانیسم‌های پاتولوژیک و استراتژی‌های درمانی مختلف به نانوحامل‌های مربوطه وارد می‌کند تا مستقیماً محل ضایعه را هدف قرار دهد. این استراتژی به طور موثرتری ناحیه پلاک آترواسکلروتیک را هدف قرار می دهد و غلظت دارو را برای بهبود جریان خون میوکارد افزایش می دهد.
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