Evaluation of antimicrobial effects of synthesized Zinc sulphide nanoparticles and their potentiation by the anticancer drug imatinib
الموضوعات : International Journal of Heterocyclic ChemistryBushra Issa Kayid Al-Zuabidi 1 , Mai Yaqoob Yousif Al-Marzooq 2 , Ahmed Naser Herez Al-Musawi 3
1 - Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran
2 - Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran
3 - Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran
الکلمات المفتاحية: nanoparticles, Zinc sulfide, aqueous chemical synthesis, Antimicrobial Activity, Imatinib,
ملخص المقالة :
Zinc sulphide (ZnS) nanoparticles were synthesized by simple aqueous chemical reaction of zinc chloride and sodium sulphide in an aqueous solution. The main advantage of ZnS nanoparticles of diameter 29 nm was that the sample could be prepared by using of cheap precursors in a cost effective and eco-friendly manner. Structural, morphological and chemical composition of the prepared nanoparticles were investigated by X-Ray Diffraction(XRD),Scanning Electron Microscopy(SEM) with energy dispersion X-ray dispersive fluorescence spectroscopy (EDAX) and Fourier transform infrared (FTIR) spectroscopy. The antimicrobial effects of the zinc sulphide (ZnS) nanocrystals and the anticarcinogenic agent imatinib were studied by spot inoculation technique and also by well diffusion technique against twelve pathogenic bacterial strains. Nanoparticles of ZnS showed antimicrobial activity against both Gram positive and Gram negative strains except Shigella sonnei. The anticancer drug imatinib was inhibitory for only Gram positive organisms, Bacillus subtilis and Staphyloccus aureus. Synergism between imatinib and ZnS nanoparticles was distinctly observed in all the Gram positive strains.
