One-Pot Synthesis of Phenytoin Analogs in soilution Conditions

الموضوعات : International Journal of Heterocyclic Chemistry

Alireza Kiasat ¹ , Maryam Nikmanesh ²

1 - Department of Chemistry , Shahid Chamran University , Ahvaz , Iran
2 - Department of Chemistry , Shahid Chamran University , Ahvaz , Iran

تاريخ الإرسال : 02 الإثنين , ربيع الأول, 1434 تاريخ التأكيد : 04 الثلاثاء , رجب, 1434 تاريخ الإصدار : 22 السبت , رجب, 1434

الکلمات المفتاحية: Green Chemistry, Synthesis, solvent free, Phenytoin, Grinding,

ملخص المقالة :

phenytoine derivatives were synthesized , via the pinacol condensation with thereaction of 1,3- diphenyl- propane- 1,3- dione (benzyl) analogs with urea or thioureain presence of slica gel and solid KOH as Solid phase catalyst in the mortar / pestle atroom temperatures. The reaction was completed at short reaction times (approximately15min) and pure products were obtained with high yields (81-94%).