Synthesis of thiadiazine-3,7-diamine derivatives
الموضوعات : International Journal of Heterocyclic Chemistry
Nima Razzaghi – asl
1
(Department of pharmaceutical chemistry , ardabil university of medical sciences , ardabil , iran)
Mohammad Kazem Mohammadi
2
(Factually of Science, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran.)
الکلمات المفتاحية: heterocyclization, 5- bromo- 2, 4- dichloro-6- methylpyrimidine, 2-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-2-methylhydrazine, phenylthioisothiocyanate,
ملخص المقالة :
New 1,5-tetra alkyl methyl- phenyl-1H-pyrimido[4,5-e][1,3,4]thiadiazine-3,7-diamine were synthesized via the cyclocondensation of 2-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-2-methylhydrazine with phenylthioisothiocyanate and further replacement of chlorine atom on the seven number position of pyrimido[4, 5- e][1, 3, 4]thiadiazin by appropriate secondary amines in simple and efficient methods.
