Synthesis of thiadiazine-3,7-diamine derivatives

الموضوعات : International Journal of Heterocyclic Chemistry

Nima Razzaghi – asl ¹ , Mohammad Kazem Mohammadi ²

1 - Department of pharmaceutical chemistry , ardabil university of medical sciences , ardabil , iran
2 - Factually of Science, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran.

تاريخ الإرسال : 13 الثلاثاء , ربيع الأول, 1435 تاريخ التأكيد : 15 الأربعاء , رجب, 1435 تاريخ الإصدار : 03 الأحد , شعبان, 1435

الکلمات المفتاحية: heterocyclization, 5- bromo- 2, 4- dichloro-6- methylpyrimidine, 2-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-2-methylhydrazine, phenylthioisothiocyanate,

ملخص المقالة :

New 1,5-tetra alkyl methyl- phenyl-1H-pyrimido[4,5-e][1,3,4]thiadiazine-3,7-diamine were synthesized via the cyclocondensation of 2-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-2-methylhydrazine with phenylthioisothiocyanate and further replacement of chlorine atom on the seven number position of pyrimido[4, 5- e][1, 3, 4]thiadiazin by appropriate secondary amines in simple and efficient methods.