One-Pot Synthesis of Phenytoin Analogs in Solvent free Conditions Via the Use of Pestle/ Mortar

الموضوعات : International Journal of Heterocyclic Chemistry

Alireza Kiasat ¹ , Maryam Nikmanesh ²

1 - Department of Chemistry , Shahid Chamran University , Ahwaz , Iran
2 - Department of Chemistry , Shahid Chamran University , Ahwaz , Iran

تاريخ الإرسال : 25 الأربعاء , شعبان, 1437 تاريخ التأكيد : 25 الأربعاء , شعبان, 1437 تاريخ الإصدار : 10 الثلاثاء , جمادى الثانية, 1433

الکلمات المفتاحية: Green Chemistry, Synthesis, solvent free, Phenytoin, Grinding,

ملخص المقالة :

phenytoine derivatives were synthesized , via the pinacol condensation with the reaction of 1,3- diphenyl- propane- 1,3- dione (benzyl) analogs with urea or thiourea in presence of slica gel and solid KOH as Solid phase catalyst in the mortar / pestle at room temperatures. The reaction was completed at short reaction times (approximately 15min) and pure products were obtained with high yields (81-94%).