Convenient synthesis of tetrazolo[1,5-b]pyridazine derivatives
الموضوعات : International Journal of Heterocyclic ChemistryMaryam Manasir 1 , Mohsen Nikpour 2
1 - Department of Chemistry, Faculty of Sciences, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran
2 - Department of Chemistry, Faculty of Sciences, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran
الکلمات المفتاحية: Hydrazine, diazotization, 3, 6-dichloropyridazine, tetrazolo[1, 5-b]pyridazine,
ملخص المقالة :
Reaction of 3,6-dichloropyridazine with hydrazine gave 1-(6-chloropyridazin-3-yl) hydrazine in high yield in ethanol at room temperature. Diazotization of the latter compound converted it to 6-chlorotetrazolo[1,5-b]pyridazine quantitatively in ice bath. 6-Chlorotetrazolo[1,5-b]pyridazine underwent a chlorine substitution is ethanol with amines at room temperature.The reaction mechanism and spectral data is discussed.
