Synthesis of alkyl 2-(4-oxoquinazolin-3(4H)-yl) acrylate by nucleophilic additionof alkyl propiolates catalysed by Ph3P

الموضوعات : International Journal of Heterocyclic Chemistry

Mehdi babakeshizadeh ¹ , Bita Mohtat ²

1 - Department of Organic Chemistry, Karaj Branch, Islamic Azad university, Karaj, Iran
2 - Department of Organic Chemistry, Karaj Branch, Islamic Azad university, Karaj, Iran

تاريخ الإرسال : 24 الثلاثاء , شعبان, 1437 تاريخ التأكيد : 24 الثلاثاء , شعبان, 1437 تاريخ الإصدار : 10 الثلاثاء , جمادى الثانية, 1433

الکلمات المفتاحية: Alkyl propiolates, Triphenylphosphine, 4-Hydroxyquinazoline, alkylacrylat,

ملخص المقالة :

4-Hydroxyquinazoline undergoes neutral conditions with alkyl propiolates in the presence of triphenylphosphine (0.26g), and by α substituation the corresponding 2-(4-oxoquinazolin-3(4H)-yl acrylate was obtained in good yields.