Novel synthesis of Pyrimido[4,5- e] [1,3,4] thiadiazines
الموضوعات : International Journal of Heterocyclic Chemistry
1 - Department of Nursing, Faculty of Nursing and Midwifery, Islamic Azad University, Ahvaz Branch, Ahvaz, Iran
الکلمات المفتاحية: 1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine, pyrimidothiadiazine, dimethylthiocarbamoylchloride, 15- lipoxygenase,
ملخص المقالة :
Treatment of 1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine with dimethylthiocarbamoylchloride gave 7-chloro-N,N,1,5-tetramethyl-1H-pyrimido[4,5-e][1,3,4]thiadiazin-3-amine in basic acetonitrile. The latter compounds were reacted with secondary amines in boiling ethanol to afford the related 7-amino derivatives.
[1] T. Naka and S. Furukawa, Japan. Kokai, 78 31,694 (Cl. C07D487/04), 25 Mar 1978, Appl. 76/105, 191, 01 Sep 1976; 10pp [Chem. Abstr., 89, 109596].
[2] H. Ogura, H. Takahashi, and M. Sakaguchi, Nucl. Acid. Res., 1978, 1, s251.
[3] T. Naka and S. Furukawa, Japan. Kokai, 78 28,192 (Cl. C07D513/04), 16 Mar 1978, Appl. 76/101, 923, 25 Aug 1976; 8pp [Chem. Abstr., 89, 59905].
[4] T. Naka and S. Furukawa, Japan. Kokai, 78 31,694 (Cl. C07D487/04), 25 Mar 1978, Appl. 76/105, 191, 01 Sep 1976; 10pp [Chem. Abstr., 89, 109596].
[5] Bakavoli, M., Nikpour, M., Rahimizadeh, M., Saberi, M. R., Sadeghian, H., Bioorg. Med. Chem., 15 (5), 2120 (2007).
[6] Bakavoli, M., Sadeghian, H., Tabatabaei, Z., Rezaei, E., Rahimizadeh, M., Nikpour, M., J. Mol. Model., 14, 471 (2008).
[7] Nikpour, M., Mirzaei, M., Chen, Y.-G., Kaju, A.A., Bakavoli, M., Inorg. Chem.Commun., 12, 879 (2009).
[8] Nikpour, M., Sadeghian, H., Saberi, M. R., Shafiee N., R., Seyedi, S. M., Hosseini, A., Parsaee, H., Taghian D. B., A., Bioorg. Med. Chem., 18, 855 (2010).
[9] Rahimizadeh, M., Nikpour, M., Bakavoli, M., J. Heterocycl. Chem., 44, 463 (2007).
[10] Bakavoli, M., Nikpour, M., Rahimizadeh, M., J. Heterocycl. Chem., 43, 1327 (2006).
