Effect of 8 weeks regular resistance training on attenuation of sdLDL changes after single session of heavy resistance exercise
الموضوعات : Journal of Physical Activity and HormonesHamid Reza Nayeri khoob 1 , Mehrzad Moghadasi 2
1 - Department of Exercise physiology, Marvdasht branch, Islamic Azad University, Marvdasht, Iran
2 - Department of Exercise physiology, Shiraz branch, Islamic Azad University, Shiraz, Iran
الکلمات المفتاحية: Regular training, sdLDL, Cardiovascular risk factors, Heavy resistance exercise,
ملخص المقالة :
Introduction: Although heavy exercise can independently increase free radical production that may enhance the susceptibility of LDL to oxidation and create more atherogenic LDL particles such as sdLDL, regular training may attenuate these atherogenic conditions. The aim of present study was to investigate the effect of 8 weeks regular resistance training on attenuation of sdLDL changes after single session of heavy resistance exercise. Material & Methods: Elevenhealthy young men (aged: 26.6 ± 1.5 years; ± SD) volunteered to participate in this study. One reparation maximum (1-RM) was measured and the subjects were performed a heavy resistance exercise trial consisted of eight exercises (chest press, triceps extension, latissimus pull down, shoulder press, arm curls, leg extension, leg curls, and curl-up) of 8 repetitions with 3 sets at 80% of 1RM. Thereafter, the subjects were performed the same 8 stations resistance training in 3 sets with 6-12 maximal repetitions. This training was performed 3 days a week with 65-80% of 1-RM, for 8 weeks. After the 8 weeks intervention, the heavy resistance exercise trial was performed a gain. Blood samples were taken at baseline (1st step), immediately after the first heavy resistance exercise trial (2nd step), 48h after 8 weeks intervention (3rd step) and immediately after the second heavy resistance exercise trial (4th step). Results: The results showed that sdLDL level was increased after the first heavy resistance exercise trial (P<0.05). After 8 weeks exercise training, sdLDL was decreased compared to 2nd step of blood sampling (P<0.05) and no significant change was observed in sdLDL in this step compare to the baseline. The results indicated that sdLDL level had not significant change after the second heavy resistance exercise trial compare to the 2nd step of blood sampling. Conclusions: The results suggest regular resistance training with specific intensity and duration utilized in this study, attenuate sdLDL changes after single session of heavy resistance exercise.
1. American Heart Association. Heart disease and stroke statistics 2004 update. Dallas (Tex) 7 American Heart Association; 2003.
2. Rifai N, Warnick GR, Dominiczak MH. Handbook of lipoprotein testing. 2nd ed, Washington (DC) 7 AACC Press; 2000.
3. Cromwell WC, Otvos JD. Low-density lipoprotein particle number and risk for cardiovascular disease. Curr Atheroscler Rep 2004; 6: 381- 387.
4. Rosenson RS, Otvos JD, Freedman DS. Relations of lipoprotein subclass levels and low-density lipoprotein size to progression of coronary artery disease in the Pravastatin Limitation of Atherosclerosis in the Coronary Arteries (PLAC-I) trial. Am J Cardiol 2002; 90: 89 - 94.
5. Shadid S, LaForge R, Otvos JD, Jensen MD. Treatment of obesity with diet/exercise versus pioglitazone has distinct effects on lipoprotein particle size. Atherosclerosis 2006; 188: 370- 376.
6. Cheung MC, Brown BG, Wolf AC, Albers JJ. Altered particle size distribution of apolipoprotein A-I–containing lipoproteins in subjects with coronary artery disease. J Lipid Res 1991; 32: 383- 394.
7. Kraus WE, Houmard JA, Duscha BD, Knetzger KJ, Wharton MB, McCartney JS, et al. Effects of the amount and intensity of exercise on plasma lipoproteins. N Engl J Med 2002; 347: 1483 - 1492.
8. Zilversmit DB. Atherogenic nature of triglycerides, postprandial lipidemia, and triglyceride-rich remnant lipoproteins. Clin Chem 1995; 41: 153 -158.
9. Leon AS and Sanchez OA. Response of blood lipids to exercise training alone or combined with dietary intervention. Med Sci Sports Exerc 2001; 33: S502 – S515.
10. Leon AS, Sanchez O. Meta-analysis of the effects of aerobic exercise training on blood lipids. Circulation 2001; 104 (Suppl II): II-414 – II415.
11. Durstine JL, Grandjean PW, Cox CA, Thompson PD. Lipids, lipoproteins, and exercise. J Cardiopulm Rehabil 2002; 22: 385- 398.
12. Mattsson N, Magnussen CG, Ronnemaa T, Mallat Z, Benessiano J, Jula A, et al. Metabolic syndrome and carotid intima-media thickness in young adults: roles of apolipoprotein B, apolipoprotein A-I, C-reactive protein, and secretory phospholipase A2: the cardiovascular risk in young Finns study. Arterioscler Thromb Vac Biol 2010, 30: 1861-1866.
13. Halle M, Berg A, Garwers U, Baumstark MW, Knisel W, Grathwohl D, et al. Influence of 4 weeks' intervention by exercise and diet on lowdensity lipoprotein subfractions in obese men with type 2 diabetes. Metabolism 1999, 48: 641-644.
14. Kaikkonen J, Porkkala-Sarataho E, Tuomainen TP, Salonen JT. Exhaustive exercise increases plasma/serum total oxidation resistance in moderately trained men and women, whereas their VLDL + LDL lipoprotein fraction is more susceptible to oxidation. Scand J Clin Lab Invest 2002; 62: 599-607.
15. Kraemer WJ, Häkkinen K, Newton RU, Nindl BC, Volek JS, McCormick M, et al. Effects of heavy-resistance training on hormonal response patterns in younger versus older men. J Appl Physiol 1999; 87: 982-992.
16. Ahmadizad S and El-Sayed MS. The effects of graded resistance exercise on platelet aggregation and activation. Med Sci Sports Exerc 2003; 35: 1026-1033.
17. American Collage of Sport Medicine. Guidelines for exercise testing and prescription. Philadelphia: Lippincott Williams & Wilkins 2005; 57-90.
18. Srisawasdi P, Chaloeysup S, Teerajetgul Y, Pocathikorn A, Sukasem C, Vanavanan S, et al. Estimation of plasma small dense LDL cholesterol from classic lipid measures. Am J Clin Pathol 2011; 136: 20-29.
19. Coresh J, Kwiterovich PO Jr, Smith HH, Bachorik PS: Association of plasma triglyceride concentration and LDL particle diameter, density, and chemical composition with premature coronary artery disease in men and women. J Lipid Res 1993; 34: 1687–1697.
20. Lamarche B, Tchernof A, Moorjani S, Cantin B, Dagenais GR, Lupien PJ, Despres JP: Small, dense low-density lipoprotein particles as a predictor of the risk of ischemic heart disease in men. Prospective results from the Quebec Cardiovascular Study. Circulation 1997; 95: 69–75.
21. Medlow P, McEneny J, Murphy MH, Trinick T, Duly E, Davison GW. Lipoprotein subfraction oxidation in acute exercise and ageing. Free Radical Res 2016; 50: 345-353.
22. Kraus W, Houmard J, Duscha B, Knetzger K, Wharton M, McCarthy J, et al. Effects of the amount and intensity of exercise on plasma lipoproteins. N Engl J Med 2002; 347: 1483-1492.
23. Halle M, Berg A, Garwers U, Baumstark MW, Knisel W, Grathwohl D, Konig D, Keul J. Influence of 4 weeks' intervention by exercise and diet on low-density lipoprotein subfractions in obese men with type 2 diabetes. Metabolism 1999; 48: 641-644.
24. Martin SE. The effect of resistance, endurance, and combination exercise on lipid metabolism and non-traditional cardiovascular disease risk markers in previously untrained men. Doctoral thesis, 2008.
25. Skoglund-Andersson C, Tang R, Bond MG, de Faire U, Hamsten A, Karpe F. LDL particle size distribution is associated with carotid intima-media thickness in healthy 50-year-old men. Arterioscleros Thrombos Vas Biol 1999; 19: 2422-2430.
26. Tsimikas S, Willerson JT, Ridker PM. C-reactive protein and other emerging blood biomarkers to optimize risk stratification of vulnerable patients. J Am Coll Cardiol 2006; 47: C19-C31
27. Zambon A, Hokanson JE, Brown BG, Brunzell JD. Evidence for a new pathophysiological mechanism for coronary artery disease regression: hepatic lipase-mediated changes in LDL density. Circulation1999; 99: 1959-1964.
28. Zambon A, Austin MA, Brown BG, Hokanson JE, Brunzell JD. Effect of hepatic lipase on LDL in normal men and those with coronary artery disease. Arterioscler Thromb 1993; 13: 147-153.
29. Zambon A, Austin MA, Brown BG, Hokanson JE, Brunzell JD. Effects of hepatic lipase on LDL in normal men and those with coronary artery disease. Arterioscler Thromb 1993; 13: 147–153.
30. Johansson J, Carlson LA, Landou C, Hamsten A. High-density lipoproteins and coronary atherosclerosis: a strong inverse relation with the largest particles is confined to normo-triglyceridemic patients. Arterioscler Thromb 1991; 11: 174 –182.
31. Herbert PN, Bernier DN, Cullinane EM, Edelstein L, Kantor MA, Thompson PD. High-density lipoprotein metabolism in runners and sedentary men. JAMA 1984; 252: 1034 –1037.
