Eight weeks resistance training reduces interlukin-17 in women with multiple sclerosis
الموضوعات : Journal of Physical Activity and Hormones
Amir Rahimi
1
(MS in Exercise Physiology, Department of Exercise physiology, Marvdasht branch, Islamic Azad University, Marvdasht, Iran.)
الکلمات المفتاحية: Resistance training, Inflammation, cytokines, Multiple Sclerosis,
ملخص المقالة :
Introduction: Multiple sclerosis (MS) is an immune mediated demyelinating disease of the central nervous system. The aim of present study was to investigate the effect of eight weeks resistance training on interlukin-17 (IL-17) in women with MS. Material & Methods: Twenty seven women with MS disease in a range of 18-48 year of old and EDSS lower than 4.5 participated in this study as the subject. Subjects were divided into control group (n=13) or training group (n=14) randomly. The training group performed progressive resistance training program, 3 days a week for 8 weeks, whereas control group continued their usual routine activities. Serum level of IL-17 was measured by ELISA kits before and after training. Results: The disability score and IL-17 were significantly decreased from 1.8 to 1.3 and from 716.3 to 601.3 pg/ml respectively in test MS subjects after 8 weeks resistance training. Conclusions: In summary, the results suggest that resistance training has useful anti-inflammatory effects by decrease in serum IL-17 production in women with MS.
1. Sospedra M, Martin R. Immunology of multiple sclerosis. Annu Rev Immunol 2005; 23: 683-747.
2. Babaloo Z, Yeganeh RK, Farhoodi M, Baradaran B, Bonyadi M, Aghebati L. Increased IL-17A but decreased IL-27 serum levels in patients with multiple sclerosis. Iran J Immunol 2013; 10: 47-54.
3. Compston A, Coles A. Multiple sclerosis. Lancet 2002; 359: 1221-31.
4. Registered A, Login P, Options P, Access S. Environmental factors and multiple sclerosis. Lancet Neurol 2008; 7: 268-277.
5. El-behi M, Ciric B, Yu S, Zhang GX, Fitzqerald DC, Rostami A. Differential effect of IL-27 on developing versus committed Th17 cells. J Immunol 2009; 183: 4957-4967.
6. Zhang J, Hutton G. Role of magnetic resonance imaging and immunotherapy in treating multiple sclerosis. Annu Rev Med 2005; 56: 273-302.
7. Bitsch A, Schuchardt J, Bunkowski S, Kuhlmann T, Brück W. Acute axonal injury in multiple sclerosis correlation with demyelination and inflammation. Brain 2000; 123, 1174-1183.
8. Al-Shammri S, Rawoot P, Azizieh F, AbuQoora A, Hanna M, Saminathan T, et al. Th1/Th2 cytokine patterns and clinical profiles during and after pregnancy in women with multiple sclerosis. J Neurol Sci 2004; 222: 21-27.
9. Imitola J, Chitnis T, Khoury S. Cytokines in multiple sclerosis: from bench to bedside. Pharmacol Ther 2005; 106: 163-177.
10. Lassmann H, Ransohoff R. The CD4-Th1 model for multiple sclerosis: a crucial re-appraisal. Trends Immunol 2004; 25: 132-137.
11. Gutcher I, Urich E, Wolter K, Prinz M, Becher B. Interleukin 18-independent engagement of interleukin 18 receptor – is required for autoimmune inflammation. Nat Immunol 2006; 7: 946-953.
12. Weaver C, Harrington L, Mangan P, Gavrieli M, Murphy K. Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity 2006; 24: 677-688.
13. Stromnes I, Cerretti L, Liggitt D, Harris R, Goverman J. Differential regulation of central nervous system autoimmunity by TH1 and TH17 cells. Nat Med 2008; 14: 337-342.
14. Cannella B, Raine C. Multiple sclerosis: cytokine receptors on oligodendrocytes predict innate regulation. Ann Neurol 2003; 55: 46-57.
15. Zeis T, Graumann U, Reynolds R, Schaeren-Wiemers N. Normal-appearing white matter in multiple sclerosis is in a subtle balance between inflammation and neuroprotection. Brain 2008; 131: 288-303.
16. Babaloo Z, Babaie F, Farhoodi M, Aliparasti MR, Baradaran B, Almasi S, et al. Interleukin-17A and interleukin-17F mRNA expression in peripheral blood mononuclear cells of patients with multiple sclerosis. Iran J Immunol 2010; 7: 202-209.
17 Matusevicius D, Kivisakk P, He B, Kostulas N, Ozenci V, Fredrikson S, et al. Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis. Mult Scler 1999; 5: 101-104.
18. Gold R, Lühder F. Interleukin-17-extended features of a key player in multiple sclerosis. Am J Pathol 2008; 172: 8-10.
19. Wraith DC. Anti-cytokine vaccines and the immunotherapy of autoimmune diseases. Eur J Immunol 2006; 36: 2844-2848.
20. Goldhammer E, Tanchilevitch A, Maor I, Beniamini Y, Rosenschein U, Sagiv M. Exercise training modulates cytokines activity in coronary heart disease patients. Int J Cardiol 2005; 100: 93-99.
21. Niessner A, Richter B, Penka M, Steiner S, Strasser B, Ziegler S, et al. Endurance training reduces circulating inflammatory markers in persons at risk of coronary events: impact on plaque stabilization? Atherosclerosis 2006; 186: 160-165.
22. Santos R, Tufik S, De Mello M. Exercise, sleep and cytokines: is there a relation? Sleep Med Rev 2007; 11: 231-239.
23. Petersen A, Pedersen B. The anti-inflammatory effect of exercise. J Appl Physiol 2005; 98: 1154.
24. Timmons B. Paediatric exercise immunology: health and clinical applications. Exerc Immunol Rev 2005; 11: 108-144.
25. Golzari Z, Shabkhiz F, Soudi S, Kordi MR, Hashemi SM. Combined exercise training reduces IFN-γ and IL-17 levels in the plasma and the supernatant of peripheral blood mononuclear cells in women with multiple sclerosis. Int Immunopharmacol 2010; 10: 1415-1419.
26. Bahrami A, Saremi A. Effect of caloric restriction with or without aerobic training on body composition, blood lipid profile, insulin resistance, and inflammatory marker in middle-age obese/overweight men. Arak Med Univ J 2011; 14: 11-19.
27. Formica CA, Cosman F, Nieves J, Herbert J, Lindsay R. Reduced bone mass and fat-free mass in women with multiple sclerosis: effects of ambulatory status and glucocorticoid Use. Calcif Tissue Int 1997; 61: 129-133.
28. Dalgas U, Stenager E, Jakobsen J, Petersen T, Hansen HJ, Knudsen C, et al. Resistance training improves muscle strength and functional capacity in multiple sclerosis. Neurology 2009; 73: 1478-1484.
29. White LJ, McCoy SC, Castellano V, Gutierrez G, Stevens JE, Walter GA, et al. Resistance training improves strength and functional capacity in persons with multiple sclerosis. Mult Scler 2004; 10: 668-674.
30. Moradi M, Sahraian MA, Aghsaie A, Kordi MR, Meysamie A, Abolhasani M, et al. Effects of eight-week resistance training program in men with multiple sclerosis. Asian J Sports Med 2015; 6: e22838.
31. Broekmans T, Roelants M, Feys P, Alders G, Gijbels D, Hanssen I, et al. Effects of long-term resistance training and simultaneous electro-stimulation on muscle strength and functional mobility in multiple sclerosis. Mult Scler 2011; 17: 468-477.
32. Hintzen R, Polman C. Th-cell modulation in multiple sclerosis. Immunol Today 1997; 18: 507.
33. Kebir H, Kreymborg K, Ifergan I, Dodelet-Devillers A, Cayrol R, Bernard M, et al. Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nat Med 2007; 13: 1173-1175.
34. Heidarianpour A, Vahidian Rezazadeh M, Zamani A. Effect of moderate exercise on serum interferon-gamma and interleukin-17 levels in the morphine withdrawal period. Int J High Risk Behav Addict 2016; 5: e26907.
35. Lowder T, Dugger K, Estell K, Deshane J, Schwiebert L. Exercise increases regulatory T cell function and decreases Th2 and Th17 cytokine production in healthy and asthmatic mice. J Immunol 2010; 184: 97-15.
