An Efficient and One-pot Procedure for the Synthesis of Chiral Isoxazolidine via Catalytic Highly Enantioselective 1,3-dipolar cycloaddition

الموضوعات :

Mohammad Javad Taghizadeh ¹

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تاريخ الإرسال : 17 الجمعة , شوال, 1437 تاريخ التأكيد : 17 الجمعة , شوال, 1437 تاريخ الإصدار : 24 الأحد , رجب, 1437

الکلمات المفتاحية:

ملخص المقالة :

Synthesis of enantiomerically pure isoxazolidine via an asymmetric 1,3- dipolar cycloaddition reaction of nitrone with electron-deficient dipolarophile was described. The process occurs at room temperature in aqueous ethanol as a green solvent and in the presence of a bidendate bis(imine)–Cu(II)triflate complex as catalyst. The reaction mechanism is discussed on the basis of the assignment of the absolute configuration of the cycloadducts.