One-pot Synthesis of Polysubstituted Indolizine Derivatives

الموضوعات :

Mohammad Piltan ¹ , Seyed Amir Zarei ² , Hassan Saydi ³ , Ashraf Sadat Shahvelayati ⁴

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تاريخ الإرسال : 17 الجمعة , شوال, 1437 تاريخ التأكيد : 17 الجمعة , شوال, 1437 تاريخ الإصدار : 26 الجمعة , رمضان, 1437

الکلمات المفتاحية:

ملخص المقالة :

An efficient approach to the synthesis of 1,2,3-trisubstituted indolizines is described via one-pot reactions of pyridine and dialkyl acetylendicarboxylate in the presence of ethyl 2-chloroacetoacetate in MeOH at room temperature. The corresponding 1, 2, 3-trisubstituted indolizines may be useful building blocks for the construction of complex indolizine derivatives.