Trichloroacetic Acid as an Efficient Catalyst for One-pot Synthesis of Highly Functionalized Piperidines via multi-component Reaction

الموضوعات :

Nourallah Hazeri ¹ , Elham Fereidooni ²

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تاريخ الإرسال : 17 الإثنين , ربيع الأول, 1437 تاريخ التأكيد : 17 الإثنين , ربيع الأول, 1437 تاريخ الإصدار : 18 الخميس , ذو الحجة, 1436

الکلمات المفتاحية:

ملخص المقالة :

Trichloroacetic Acid (TCA) was used as an efficient catalyst for the synthesis of highly functionalized piperidines via a one-pot five-component reaction of aromatic amines, aromatic aldehydes andβ-keto esters in MeOH at room temperature. The remarkable advantages offered by this method are good yields, simple procedure, short reaction times, no need to column chromatography and an easy work-up.