Modification of Polyvinyl Alcohol via Atom Transfer Radical Polymerization for Targeted Drug Delivery Applications

الموضوعات :

Sedigheh Ehsanimehr ¹ ()
Peyman Najafi Moghadam ² ()
Nasim Movagharnezhad ³ ()
Amir Reza Fareghi ⁴ ()

تاريخ الإرسال : 02 السبت , ربيع الثاني, 1438 تاريخ التأكيد : 02 السبت , ربيع الثاني, 1438 تاريخ الإصدار : 30 السبت , ذو الحجة, 1437

الکلمات المفتاحية:

ملخص المقالة :

In current study,a hydrogel based on biocompatible polymerwas prepared. The functionalization of polyvinyl alcohol (PVA)with epichlorohydrin(ECH) to produce epichlorohydrin-g-polyvinyl alcohol (PVA/ECH) as a suitable macroinitiator for atom transfer radical polymerization (ATRP) reaction was investigated.ThenN-vinyl pyrrolidone (NVP) waspolymerized on the surface of macroinitiatorin presence of CuCl as a catalyst and Pentamethyldiethylenetriamine (PMDETA) as aligand using ATRP to produce PNVP-g-PVA. The synthesized copolymer was characterized by Fourier transform infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC). Also equilibrium swelling was studied in distilled water and indicated the sustained expansion of them. At last, loading capacity and release profiles of ceftriaxone as a model drug from the hydrogel were determined by UV– Vis absorption measurement at λmax= 243 nm. In vitro drug release behavior was investigated in three different media (HCl solution: pH=3 and bicarbonate buffer solutions: pH=7 and pH=8).