Designed a Fluorescent Method by Using PbS with Gelatin via Quantum Dots for the Determination of Phenylpropanolamine Drug in Human Fluid Samples

الموضوعات :

Shirin Bouroumand ¹ , Farzaneh Marahel ² , Fereydoon Khazali ³

1 - Department of Chemistry, Omidiyeh Branch, Islamic Azad University, Omidiyeh, Iran
2 - Department of Chemistry, Omidiyeh Branch, Islamic Azad University, Omidiyeh, Iran
3 - Department of Chemistry, Omidiyeh Branch, Islamic Azad University, Omidiyeh, Iran

تاريخ الإرسال : 22 السبت , رمضان, 1443 تاريخ التأكيد : 22 السبت , رمضان, 1443 تاريخ الإصدار : 02 الجمعة , ذو الحجة, 1443

الکلمات المفتاحية:

ملخص المقالة :

Fluorescent chemical sensors to detect drugs, by increasing fluorescence emission and absorption or by shutting down, because they are non-destructive, the ability to show decomposed concentrations, fast response, high accuracy have been considered and used. In this research, a chemical sensor was synthesized PbS functionalized with gelatin quantum dots for Phenylpropanolamine (PPA) drug. The calibration curve was linear in the range of (0.05 to 10.0 µgL−1). The standard deviation of less than (2.0 %), and detection limits (3S/m) of the method (0.05 µgL−1) in time 60 s, 335 nm were obtained for sensor level response PbS Quantum Dot–Gelatin nanocomposites sensor with (99 %), confidence evaluated. The observed outcomes confirmed the suitability recovery and a very low detection limit for measuring the Phenylpropanolamine drug. The method fluorometric introduced to measure Phenylpropanolamine in real samples such as urine and blood was used and can be used for other drugs and hospital samples. The chemical PbS Quantum Dot–Gelatin nanocomposites sensor made it possible as an excellent sensor with good reproducibility.

المصادر:

[1]. S. Tanreh, A. Shameli, E. Balali, J. Appl. Chem. Res., 12, 79 (2018).
[2]. J. N. Kim, J. E. Cho, J. Toxicol. Environ. Health A., 84, 529 (2021).
[3]. N. A. Flavahan, J. Pharmacol. Experim. Therape., 313, 432 (2005).
[4]. R. Bruckner, I. Hackbarth, T. Meinertz, B. Schmelzle, H. Scholz, Naunyn-Schmiedeberg's
Archives of Pharmacology., 303, 205 (1978).
[5]. British Pharmacopoeia. The stationery office, electronic version. London., 305, 1227 (2013).
[6]. A.L. Suryan, V.K. Bhusari, K.S. Rasal, S.R. Dhaneshwar, Int. J. Pharm. Sci. Drug. Res., 3, 303
(2011).
[7]. E.E. Balint, G. Falkay, G.A. Balint, Khat - A controversial plant. Wien Klin Wochenschr., 121,
604 (2009).
[8]. S. Azhagvuel, R. Sekar, J. Pharm. Biomed. Anal., 43, 873 (2007).
[9]. P. Vinas, C. Lopez‑Erroz, F.J. Hernandez‑Cordoba, Talanta., 47, 455 (1998).
[10]. K. Abbasia, M.I. Bhangera, M.Y. Khuhawar, J. Pharm. Biomed. Anal., 41, 998 (2006).
[11]. K. Sunil, K. Yogesh, K. Abhijeet, Int. J. Pharm. Life Sci., 4, 3122 (2013).
[12]. M.I. Walash, N. El‑Enany, S. Saad, Int. J. Biomed. Sci., 6, 150 (2010).
[13]. A. Hatamie, F. Marahel, A. Sharifat, Talanta., 176, 518 (2018).
[14]. Z. Qiu, J. Shu, Y. He, Z. Lin, K. Zhang, S. Lv, D. Tang, Biosens. Bioelectron., 87, 18 (2017).
[15]. G.H. Kim, D.H. Cha, R.M. Nepal, T.C. Jeong, J. Toxicol. Environ. Health A., 84, 783 (2021).
[16]. Sh. Lv, Y. Tang, K. Zhang, D. Tang, Anal. Chem., 90, 14121 (2018).
[17]. A. Dos, M. Wai, Ultrasonic Sonochemistry., 21, 892 (2014).
[18]. Z. Lin, Sh. Lv, K. Zhang, D. Tang, J. Mater. Chem. B., 5, 826 (2017).
[19]. Sh. Bouroumand, F. Marahel, F. Khazali, Iran. J. Anal. Chem., 7, 47 (2020).
[20]. Q. Zhou, Y. Lin, M. Xu, Z. Gao, H. Yang, D. Tang, Anal. Chem., 88, 8886 (2016).
[21]. E.G. Martyanova, S.B. Brichkin, M.G. Spirin, V.F. Razumov, High Energy Chem., 51, 350
(2017).
[22]. A. Shokry, M. Khalil, H. Ibrahim, M. Soliman, S. Ebrahim, Scientiic Reports., 11, 5336
(2021).
[23]. F. Marahel, L. Niknam, Drug. Chem. Toxicol., 44, 1 (2021).
[24]. Z. Qiu, J. Shu, D. Tang, Anal. Chem., 89, 5152 (2017). 

[25]. P. Dutta, D. Saikia, N.C. Adhikary, N.S. Sarma, ACS. Appl. Mater. Interfaces., 7, 24778
(2015).
[26]. M. Mirsalari, S. Elhami, Spectrochim. Acta A. Mol. Biomol. Spectrosc., 240, 118617 (2020).
[27]. X. Yang, M. Liu, Y. Yin, F. Tang, H. Xu, X. Liao, Sensors, 18, 964 (2018).
[28]. L. Niknam, F. Marahel, J. Phys. Theor. Chem., 18, 37 (2021).
[29]. C. Coester, K. Langer, H. Brisen, J. Kruter, J. Micro. Encapsul., 17, 187 (2000).
[30]. H.R. Akbari Hasanjani, M.R. Sohrabi, Iran. J. Pharma. Res., 16, 478 (2017).
[31]. A. Ramzannezad, A. Hayati, A. Bahari, H. Najafi-Ashtiani, Iran. J. Basic Med. Sci., 24, 962
(2021).
[32]. Sh. Bouroumand, F. Marahel, F. Khazali, Desal. Water Treat., 223, 388 (2021).
[33]. T.S. Shyju, S. Anandhi, R. Sivakumar, R. Gopalakrishnan, Int. J. Nano. Sci., 13, 1450001
(2014).
[34]. Y. Zhao, J. Zou, W. Shi, Mater. Sci. Eng. J., 121, 20 (2005).
[35]. S. Baluta, K. Malecha, A. Swist, J. Cabaj, Sensors, 20, 1429 (2020).
[36]. N. Samadi, S. Narimani, Sensor Lett. J., 14, 530 (2016).
[37]. S.S. Liang, L. Qi, R.L. Zhang, M. Jin, Z.Q. Zhang, Sens. Actuators, 244, 585 (2017).
[38]. E. Keskin, S. Allahverdiyeva, E. Şeyho, Y. Yardim, J. Serb. Chem. Soc., 84, 1 (2019).
[39]. H. Xie, F. Zeng, S. Wu, Biomacromolecules, 15, 3383 (2014).
[40]. S. Baluta, A. Swist, J. Cabaj, K. Malecha, Int. J. Electron. Telecommunica., 66, 369 (2020).