Preparation of Novel Thermo-sensitive Polymer/βCD/WS2 Nano-carriers for invitro Drug Release of Tamoxifen in the Presence and Absence of Near-Infrared (NIR) Laser
الموضوعات :Abbas Bohloli 1 , Maryam Daghighi Asli 2 , Elham Moniri 3 , Azar Bagheri 4
1 - Department of Chemistry, Central Tehran Branch, Islamic Azad University Tehran, Iran
2 - Department of Chemistry, Central Tehran Branch, Islamic Azad University Tehran, Iran
3 - Department of Chemistry, Central Tehran Branch, Islamic Azad University Tehran, Iran
4 - Department of Chemistry, Central Tehran Branch, Islamic Azad University Tehran, Iran
الکلمات المفتاحية:
ملخص المقالة :
In this work, two novel N-isopropylacrylamide (NIPAA)/Beta-cyclodextrin (β-CD)/WS2 and NIPAA/N, Ndimethyl acrylamide (DMAA)/WS2/βCD nanocarriers were prepared for in vitro tamoxifen drug release inthe absence and presence of Near-Infrared (NIR) laser. The characterization of resulting nanocarriers wascarried out using X-ray diffraction (XRD), Fourier transforms infrared spectroscopy (FTIR), field-emissionscanning electron microscopy (FE-SEM), and thermogravimetric analysis (TGA). To study the effect oftemperature on drug release for chemotherapy, tamoxifen drug release was comparatively evaluated at threedifferent temperatures (25, 37, and 50°C) with pH 7.4 in the absence of a NIR laser. It was found thattamoxifen release from the synthesized nanocarriers at 50°C was significantly greater than that at 25 and37°C. To investigate the effect of laser light on drug release for chemo-photothermal therapy, the in vitrorelease tests were carried out at 37°C with a NIR laser light and with a power density of 1 W/cm2for 5 min.The increase of tamoxifen release after a laser light was 29.8% and 48.4%for NIPAA/βCD/WS2 andNIPAA/DMAA/βCD/WS2 samples, respectively. Thus, the combination of chemo/photothermal therapy hada synergistic effect on the drug release of tamoxifen. Furthermore, the total drug release ofNIPAA/DMAA/βCD/WS2 was greater than that of NIPAA/βCD/WS2 nanocarrier. Furthermore, the kineticrelease data were analyzed using Zero-order, First-order, Ritger-Peppas, and Higuchi models which followedthe zero-order kinetic release model. Also, good stability was observed for tamoxifen in the drug releasesystem.
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