Promoted Preparation of Aminophosphonate and Functionalized Coumarins Derivatives as Key Constituent of Many Pharmaceutical Compounds
الموضوعات :Helia Mohammadi 1 , Bita Mohtat 2 , Mehran Kordtabar 3
1 - Department of Chemistry, Karaj Branch, Islamic Azad University, Karaj, Iran
2 - Department of Chemistry, Karaj Branch, Islamic Azad University, Karaj, Iran
3 - Department of Chemistry, Karaj Branch, Islamic Azad University, Karaj, Iran
الکلمات المفتاحية:
ملخص المقالة :
The reaction between trialkyl phosphites with dialkyl actylenedicarboxylates in the presence of 2-hydroxyquinoline (2-quinolinol) leads to β-aminophsphonates derivatives which they have many applications in medicinal chemistry. When the reaction was performed by triphenylphosphite, a new pyrano quinoline compounds were obtained in fairly good yields. These compounds also provide biologically interesting. All roducts were established by IR, NMR (1H,13C and31P),mass spectroscopy and elemental analysis.
