Synthesis and Characterization of Novel 4-oxo-1,4-dihydroquinoline-3-carboxamide Derivatives from Diazomethane and HCl

الموضوعات :

Navabeh Nami ¹ , Seyed Marziyeh Kazemi ²

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تاريخ الإرسال : 17 الإثنين , ربيع الأول, 1437 تاريخ التأكيد : 17 الإثنين , ربيع الأول, 1437 تاريخ الإصدار : 18 الخميس , ذو الحجة, 1436

الکلمات المفتاحية:

ملخص المقالة :

Reaction of thionyl chloride with 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4- oxoquinoline-3-carboxylic acid 1 gave acid chloride 2. Compound 2 was reacted with glycine and D-glutamic acid to afford 2-(7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4- dihydroquinoline-3-carbonyl) aminopantandioicacid 3a and 2-(7-chloro-1-cyclopropyl-6- fluoro -4- oxo-1,4-dihydroquinoline-3-carbonyl)aminoaceticacid3b. These compounds were changed to chloromethyl ketone derivatives5a-bfrom diazomethane and then HCl(g)in dry diethyl ether.