Synthesis and Screening of Some New Isatin Containing Thiazole Derivatives for Antimicrobial Activity

الموضوعات :

Suman Adhikari ¹ , S. B. Bari ² , A. Samanta ³

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تاريخ الإرسال : 04 الإثنين , صفر, 1437 تاريخ التأكيد : 04 الإثنين , صفر, 1437 تاريخ الإصدار : 29 الأربعاء , صفر, 1435

الکلمات المفتاحية:

ملخص المقالة :

In the present work, a series of new N’-[{5-(4-aryl) 1,3-thiazol-2yl}carbohydrazide-methyl]- 3(4-arylimino) indol-2-one analogs (5a-g) had heen synthesized from 3-(4-arylimino)-2-oxo- 1-indole-acetylthiosemicarbazide (4a-g) in ethanol, in the presence of phenacyl bromide or substituted phenacyl bromides. The compound 5e was characterized by its elemental analysis, IR, 1 HNMR and Mass Spectroscopy. The synthesized compounds (5a-g) were evaluated for in vitro antibacterial activity and antifungal activity against various strains of bacteria and fungi.