Synthesis and Molecular Docking studies of Some Tetrahydroimidazo[1,2-a] pyridine Derivatives as Potent α-Glucosidase Inhibitors

الموضوعات :

Mohammad R. Asghariganjeh ¹ , Ali A. Mohammadi ² , Elham Tahanpesar ³ , Ayeh Rayatzadeh ⁴ , Somayeh Makarem ⁵

1 - Department of Chemistry, Khuzestan Science and Research Branch, Islamic Azad University, Ahvaz, Iran. Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran
2 - Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran. Chemistry and Chemical Engineering Research Center of Iran (CCERCI), 14335-186, Tehran, Iran.
3 - Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran
4 - Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran
5 - Department of Chemistry, Karaj Branch, Islamic Azad University, Karaj, Iran

تاريخ الإرسال : 17 الأربعاء , ربيع الثاني, 1442 تاريخ التأكيد : 17 الأربعاء , ربيع الثاني, 1442 تاريخ الإصدار : 17 الجمعة , جمادى الأولى, 1442

الکلمات المفتاحية:

ملخص المقالة :

KAl(SO4)2.12H2O is found to efficiently and heterogeneously catalyze the one-pot three-component reaction of 2-(nitromethylene)imidazolidine, malononitrile and aldehydes under mild conditions to afford the corresponding tetrahydroimidazo[1,2-a]pyridine in good yields and short reaction times. Docking study of some compounds in the active site of α-glucosidase demonstrated that these compounds interacted with important active site residues with low binding energy in comparison to standard inhibitor acarbose.

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