Preparation and Application of Fe3O4@SiO2@OSO3H Nanocomposite as a Green Catalyst for the Synthesis of Octahydroquinazolinones
الموضوعات :
Mohammad Ali Ghasemzadeh
1
(Department of Chemistry,Qom Branch, Islamic Azad University, Qom, Iran)
الکلمات المفتاحية:
ملخص المقالة :
In this research the magnetite nanoparticles supported silica sulfonic acid(Fe3O4@SiO2@OSO3H) was used as a green and efficient catalyst for the preparation ofoctahydroquinazolinone derivatives as biologically active heterocyclic compounds. Thisprocedure avoids hazardous reagents, solvents, catalyst and can be an eco-friendly alternativeto the existing methods. The one-pot three-component reaction of aldehydes, dimedone andurea or thiourea has several advantages such as: simple procedure, eco-friendly approach,excellent yields, short reaction times, little catalyst loading, simple purification and facilecatalyst separation. In addition, the synthesis and application of Fe3O4@SiO2@OSO3Hnanocomposite as a robust and recoverable heterogeneous nanocatalyst is described. Fe3O4nanoparticles encapsulated-silica particles bearing sulfonic acid were readily recovered usingan external magnet and could be reused several times without significant loss of its reactivity.The catalyst was fully characterized by different spectroscopic techniques including VSM,FT-IR, SEM, XRD, EDX and TEM analysis.
