Reproductive Performance and Progesterone Concentration Changes on Mamasani Goats, using Human Chorionic Gonadotropin during 1.5, 2 and 7 Days after Mating on the Spring Season
الموضوعات :M. Ghaedi 1 , J. Habibizad 2 , M. Meamar 3 , M. Muhaghegh-Dolatabady 4
1 - Department of Animal Science, Faculty of Agriculture, Yasouj University, Yasouj, Iran
2 - Department of Animal Science, Faculty of Agriculture, Yasouj University, Yasouj, Iran
3 - Department of Animal Science, Faculty of Agriculture, Yasouj University, Yasouj, Iran
4 - Department of Animal Science, Faculty of Agriculture, Yasouj University, Yasouj, Iran
الکلمات المفتاحية: eCG, hCG, Mamasani goats, prolificacy rate, reproductive performance, twining rate,
ملخص المقالة :
Present study was conducted to investigate the effect of different times of using human Chorionic Gonad-otropin (hCG) during different days after mating on the reproductive performance and serum progesterone concentration of superovulated Mamasani goats. In this study, 60 goats (3-4 years) with the weight range of 46 ± 2.1 kg were used. The goats were synchronized for a period of 15 days and one day before sponge removal, 400 international units of equine chorionic gonadotropin (eCG) were injected to them. The goats were divided into 4 treatment groups based on not receiving (control) or receiving (350 international units of hCG) on one and a half, two, and 7 days after mating. Blood samples were collected on day 2 before sponging and days 19 and 40 after mating. The results showed that fecundity and prolificacy rate were sig-nificantly (P<0.0001) higher in the groups receiving hCG during days 1.5 and 2 after mating compared to the other groups. Serum progesterone concentration of pregnant, delivered, single birth and multiple births goats on 19 and 40 days after mating were significantly higher in the groups receiving hCG compared to the control group (P<0.05). Serum progesterone concentration of multiple births goats in all groups receiving hCG significantly (P<0.05) increased compared to control group in 19 and 40 days of sampling. The results generally showed that reproductive performance and serum progesterone concentration were affected by different times of using hCG and these parameters increased in goats receiving hCG in days 1.5 and 2 after mating.
Agarwal S., Gupta H.P., Prasad S., Verma P.K., Afroza Khanam A. and Firdous Ahmad Khan F.A. (2021). Effect of various hCG treatment protocols on luteal characteristics, plasma pro-gesterone concentration, and pregnancy in normal cyclic In-dian crossbred dairy cows. Trop. Anim. Health Prod. 53, 220-229.
Anvar M. and Ahmad K.M. (1999). Ovulation rate, number of fetuses and embryo loss in Teddy goats of Pakistan. Small Rumin. Res. 31, 281-283.
Bustamante-Andrade J.A., Meza-Herrera C.A., Rodriguez-Martinez R., antos-Jimenez Z., Angel-Garcia O., Gaytan-Aleman L.R., Gutierrez-Guzman U.N., Esquivel-Romo A. and Veliz-Deras F.G. (2021). Luteogenesis and embryo implanta-tion are enhanced by exogenous hCG in goats subjected to an out-of-season fixed-time artificial insemination protocol. Biology. 10, 429-439.
Cam M. and Kuran M. (2004). Effects of a single injection of hCG or GnRH agonist on day 12 post mating on fetal growth and reproductive performance of sheep. Anim. Reprod. Sci. 80, 81-90.
Carrillo E., Meza-Herrera C.A., Luna-Orozco J.R., Delgado-Gonzales R.A., Gaytan-Aleman L.R., Angel-Garcia O., Veliz, F.G. and Contreras-Villarreal V. (2019). Evaluation of out-of-season estrus induction protocols in progesterone-primed mix-breed dairy goats using eCG, GnRH and E2. Indian J. Anim. Res. 53, 711-715.
Contreras-Villarreal V., Mmza-Herrera C.A., Rivas-Munoz R., Angel-Garcia O., Luna-Orozco J.R., Carrillo E., Mellado M. and Veliz-Deras F.G. (2016). Reroductive performance of sea-sonally anovular mixedbred dairy goats induced to ovulate with a combination of progesterone and eCG or estradiol. Anim. Sci. J. 87, 750-755.
Cortes L.R., Souza-Fabjan J.M.G., Dias D.S., Martins B.B., Maia A.L.R.S., Veiga M.O., Arashiro E.K.N., Brandao F.Z., Oliveira M.E.F., Bartlewski P.M. and Fonseca J.F. (2021). Administration of a single dose of 300 IU of human chorionic gonadotropin seven days after the onset of estrus improves pregnancy rate in dairy goats by an unknown mechanism. Domest. Anim. Endocrinol. 74, 106579-106589.
Coyan K., Ataman M.B., Erdem H., Kaya A. and Kasikci G. (2003). Synchronization of estrus in cows using double PGF2 alpha, GnRH–PGF2 alpha and hCG-PGF2 alpha combination. Revue Med. Vet. 154, 91-96.
De-Castro T., Rubianes E., Menchaca A. and Rivero A. (1999). Ovarian dynamics, serum estradiol and progesterone concen-trations during the interovulatory interval in goats. Therio-genology. 52, 399-411.
Dogan I., Toker M.B., Aktar A., Yilmaz M.M. and Udum D. (2023). Effect of hCG administration on ovulation and estrus in Saanen goats subjected to short-term estrus synchronization protocol during the breeding season. J. Hellenic Vet. Med. Soc. 74, 5789-5798.
Dogruer G., Karaca F., Saribay M.K. and Cafer-Tayyar Ates C.Y. (2012). The effect of post-mating diclofenac sodium injections on the pregnancy rate of the lactating goats synchronized by buck effect at the initiation of breeding season. YYU Vet. Fak. Derg. 23, 19-22.
Engeland I.V., Waldeland H., Andresen E., LcKen T., Bjorkman C. and Bjerkas I. (1998). Foetal loss in dairy goats: An epide-miological study in 22 herds. Small Rumin. Res. 30, 37-48.
Esteves L.V., Brandao1 F.Z., Cruz R.C., Souza J.M.G., Oba E., Faco O. and Fonseca J.F. (2013). Reproductive parameters of dairy goats submitted to estrus synchronization with pros-taglandin F2α associated or not to hCG at estrous onset. Arq. Bras. Med. Vet. Zootec. 65, 1585-1592.
Fonseca J.F., Castro A.C.R., Arashiro E.K.N., Oliveira M.E.F., Zambrini F.N., Esteves L.V., Brandao F.Z. and Souza-Fabjan J.M.G. (2018). Effects of hCG administration on accessory corpus luteum formation and progesterone production in es-trous-induced nulliparous Santa Ines ewes. Anim. Reprod. 15, 135-139.
Fonseca J.F., Maffili V.V., Rodrigues M.T., Santos A.D.F., Rovay H., Pinto N.A., Brandao F.Z. and Torres C.A.A. (2006). Ef-fects of hCG on progesterone concentrations and fertility in cyclic, lactating Alpine goats. Anim. Reprod. 3, 410-414.
Fonseca J.F., Silva Filho J.M., Pinto Neto A., Palhares M.S., Ruas J.R.M., Alvin M.T.T., Belessario H. and Saliba W.P. (2001). Plasma progesterone concentration in recipient heifers submit-ted to administration of rbST, GnRH or hCG on day five of the estrous cycle. Arq. Bras. Vet. Zootec. 53, 451-458.
Fonseca J.F., Souza-Fabjan J.M.G., Oliveira M.E.F., Cruz R.C., Esteves L.V., Matos de Paiva M.P.S.L., Brandao F.Z. and Mancio A.B. (2017). Evaluation of cervical mucus and reproductive efficiency of seasonally anovular dairy goats af-ter short-term progestagen-based estrous induction protocols with different gonadotropins. Reprod. Biol. 17, 363-369.
Fonseca J.F. and Torres C.A.A. (2005). Administration of hCG 5 days after breeding and reproductive performance in nullipa-rous dairy goats. Reprod. Domest. Anim. 40, 495-499.
Fonseca F.J., Torres C.A.A., Costa E.P., Maffili V.V., Carvalho G.R., Alves N.G. and Rubert M.A. (2005). Progesterone pro-file and reproductive performance of estrous induced Alpine goats given hCG five days after breeding. Anim. Reprod. 2, 54-59.
Fonseca J.F., Vergani G.B., Cortes L.R., Rodrigues J.N.D., Siqueira L.G.B., Fabjan J.M.G.S. and Oliveira M.E.F. (2021). Induction of accessory corpus luteum in goats and sheep: From physiological basis to reproductive effects. Rev. Bras. Reprod. Anim. 45, 309-317.
Ginther O.J. and Kot K. (1994). Follicular dynamics during the ovulatory season in goats. Theriogenology. 42, 987-1001.
Gomez-Brunet A., Santiago-Moreno J., Montoro V., Garde J., Pons P., Gonzalez-Bulnes A. and Lopez-Sebastian A. (2007). Reproductive performance and progesterone secretion in es-trus-induced Manchega ewes treated with hCG at the time of AI. Small Rumin. Res. 71, 117-122.
Gonzalez-Alvarez V.H., Meza-Herrera C.A., Leyva C., Alvarado-Espino A.S., Guillen-Munoz J.M., Rodriguez-Martinez R. and Veliz-Deras F.G. (2016). Effectiveness of different hCG and GnRH based protocols in progesterone primed goats on estrus induction and reproductive outcomes in out-off-season goats. J. Anim. Res. 6, 177-182.
Gonzalez-Bulnes A., Menchaca A., Martin G.B. and Martinez-Ros P. (2020). Seventy years of progestogen treatments for man-agement of the sheep estrous cycle: Where we are and where we should go. Reprod. Fertil. Dev. 32, 441-452.
Gonzalez-Bulnes A., Santiago Moreno J., Gormez-Brunet A., Inskeep E.K. Townsend E.C. and Lopez-Sebastian A. (1999). Follicular dynamics during the oestrous cycle in dairy goats. Anim. Sci. 68, 547-554.
Gordon I. (1997). Controlled Reproduction in Sheep and Goats. Cambridge University Press, Wallingford, United Kingdom.
Habibizad J., Hoseini G., Zarrin M., Ostadyan S. and Meamar M. (2020). Effect of various eCG doses on reproductive perform-ance of Kohgiluyeh and Boyerahmad province native goats at during the summer and spring seasons. Iranian Vet. J. 16, 34-39.
Husein M.Q. and Ababneh M.M. (2008). A new strategy for supe-rior reproductive performance of ewes bred out-of-season util-izing progestagen supplement prior to withdrawal of intrav-aginal pessaries. Theriogenology. 69, 376-383.
Karaca F., Tasal I. and Alan M. (2009). Preliminary report on induction of estrus with multiple eCG injections in Colored Mohair goats during the anestrus season. Anim. Reprod. Sci. 114, 306-310.
Khan T.H., Beck N.F.G. and Khalid M. (2009). The effect of hCG treatment on Day 12 post-mating on ovarian function and re-productive performance of ewes and ewe lambs. Anim. Re-prod. Sci. 116, 162-168.
Martinod S., Maurer R.R., Siegenthaler B., Gerber C. and Hansen P.J. (1991). The effects of recombinant bovine interferon-a on fertility in ewes. Theriogenology. 36, 231-239.
Medan M.S., Watanabe G., Sasaki K., Sharawy S., Groome N.P. and Taya K. (2003). Ovarian dynamics and their associations with peripheral concentrations of gonadotropins, ovarian ster-oids, and inhibin during the estrous cycle in goats. Biol. Re-prod. 69, 57-63.
Meites J., Webster H.D., Young F.W., Thorp Jr. F. and Hatch R.N. (1951). Effects of corpora lutea removal and replacement with progesterone on pregnancy in goats. J. Anim. Sci. 10, 411-416.
Mishra S., Lei Z.M. and Rao C.V. (2003). A novel role of luteiniz-ing hormone in the embryo development in cocultures. Biol. Reprod. 68, 1455-1462.
Nancarrow C.D. (1994). Embryonic mortality in the ewe and doe. Pp. 79-97 in M.T. Zavy and R.D. Geisart, Eds., Embryonic Mortality in Domestic Species. CRC Press, London, United Kingdom.
Osman A.M., Hussein H.A. and Hassan M.S. (2021). Follicular dynamic in balady goat in upper Egypt using ultrasonography. New Valley Vet. J. 1, 8-14.
Rajamahendran R. and Sianangama P.C. (1992). Effect of human chorionic gonadotrophin on dominant follicles in cows: forma-tion of accessory corpora lutea, progesterone production and pregnancy rates. J. Reprod. Fertil. 95, 577-584.
Regassa F., Tamrat H. and Bekana M. (2007). Ovarian activity, transuterine embryo migration and prenatal loses in Ethiopian highland ewes. Trop. Anim. Health Prod. 39, 131-139.
Rodrigues J.N.D., Guimaraes J.D., Oliveira M.E.F., Dias J.H., Arrais A.M., de Sousa M.A.P., Bastos R., Ahmadi B., Bartlewski P.M. and Fonseca J.F. (2022a). Human chorionic gonadotropin affects original (ovulatory) and induced (acces-sory) corpora lutea, progesterone concentrations, and preg-nancy rates in anestrous dairy goats. Reprod. Biol. 22, 100591-100601.
Rodrigues J.N.D., Guimaraes J.D., Rangel P.S.C., Oliveira M.E.F., Brandao F.Z., Bartlewski P.M. and Fonseca J.F. (2022b). Luteal function in cyclic goats treated with human chorionic gonadotropin administered by intramuscular or in-travaginal routes at the time of artificial insemination. Reprod. Domest. Anim. 58, 396-404.
Rodrigues J.N.D., Guimaraes J.D., Rangel P.S.C., Oliveira M.E.F., Brandao F.Z., Bartlewski P.M. and Fonseca J.F. (2023). Ovarian function and pregnancy rates in dairy goats that received 300 IU of human chorionic gonadotropin (hCG) intravaginally at the time of artificial insemination. Small Ru-min. Res. 227, 107061-107071.
Rodriguez-Martinez R., Meza-Herrera C.A., Tapia-Robles K.I., Alvarado-Espino A.S., Luna-Orozco J.R., Leyva C., Mellado M. and Veliz-Deras F.G. (2018). Effect of two routes of ad-ministration of human chorionic gonadotropin upon oestrus induction and reproductive outcomes in adult acyclic mix-breed goats. J. Appl. Anim. Res. 46, 190-194.
Saleh M., Shahin M., Wuttke W., Gauly M. and Holtz W. (2012). Pharmacokinetics of human chorionic gonadotropin after i.m. administration in goats (Capra hircus). Reproduction. 144, 77-81.
Sanchez J.M., Randi F., Passaro C., Mathew D.J., Butler S.T. and Lonergan P. (2018). Effect of human chorionic gonadotrophin administration 2 days after insemination on progesterone con-centration and pregnancy per artificial insemination in lactat-ing dairy cows. J. Dairy Sci. 101, 1-12.
Saribay M.K. and Erdem H. (2007). Determination of the inci-dence of embryonic death by means of real-time ultrasound scanning in ewes. J. Vet. Sci. 23, 19-25.
SAS Institute. (2013). SAS®/STAT Software, Release 9.4. SAS Institute, Inc., Cary, NC. USA.
Schwarz T. and Wierzchos E. (1999). Relation between FSH and ovarian follicular dynamics in goats during the estrous cycle. (abstr.). Theriogenology. 52, 381-391.
Sun S., Lv M., Niu H. and Luo J. (2024) Influence of repeated estrus synchronization treatment on hormone secretion, growth, and development of dairy goats. Front. Vet. Sci. 10, 1-9.
Vergani G.B., Ferreira da Fonseca J., Trevizan J.T., Schinaider do Amaral Pereira V., Garcia A.R., Esteves S.N., Brandao F.Z., Souza-Fabjan J.M.G. and Oliveira M.E.F. (2020). Luteotropic effects of human chorionic gonadotropin administered 7.5 days after synchronous estrous induction in Morada Nova ewes. Anim. Reprod. Sci. 223, 1-11.
Weise D.W., Newton G.R. and Emesih G.C. (1993). Effects of day of the estrous cycle or pregnancy on protein secretion by caprine endometrial tissues. Biol. Reprod. 49, 522-527.
Wildeus S. (2000). Current concepts in synchronization of estrus: Sheep and goats. J. Anim. Sci. 77, 1-14.
