Mesoporous Silica Nanoparticles: A Review of Synthetic Design and Immunomodulatory Applications
الموضوعات :
طاهره نوایی دیوا
1
,
ali taleshtabardolaty
2
1 - عضو هیات علمی
2 - Department of Biology Education, Farhangian University, P.O. Box 14665-889Tehran, Iran
الکلمات المفتاحية: Mesoporous silica nanoparticles, Immunomodulation, Cancer immunotherapy, Vaccine delivery, Inflammatory diseases.,
ملخص المقالة :
Mesoporous silica nanoparticles (MSNs) are tiny, sponge-like particles made from silica that are attracting attention for their ability to influence the immune system. Thanks to their adjustable shape, size, and surface features, MSNs can be designed to carry medicines, vaccine ingredients, or immune-boosting agents to specific parts of the body at the right time. This review explains how MSNs are being explored in three major areas: cancer treatment, controlling inflammation, and improving vaccine performance. It describes how these particles interact with immune cells and how they can help activate or calm immune responses in a targeted way. Examples include using MSNs to reach key immune cells, reduce harmful inflammation, and strengthen how vaccines work. The article also discusses current challenges—such as how long MSNs stay in the body and whether they cause unwanted immune reactions—and presents new ideas to solve these issues. Overall, MSNs show promise as flexible tools for developing safer and more effective immune therapies.
