Synergistic effects of Ginkgo biloba and voluntary exercise on oxidative stress and antioxidant markers in Parkinson’s disease in mice model
الموضوعات : مجله گیاهان داروییKeivan Mehdipournezhad 1 , Khosro Jalali Dehkordi 2
1 - Department of Sport Physiology, Isf.C., Islamic Azad University, Isfahan, Iran;
2 - Department of Sport Physiology, Isf.C., Islamic Azad University, Isfahan, Iran;
الکلمات المفتاحية: Parkinson's disease, Ginkgo biloba, SOD, SIRT1, MDA, Voluntary exercise,
ملخص المقالة :
Background & Aim: Parkinson's disease (PD) is a neurodegenerative disorder marked by the degeneration of dopaminergic neurons in the substantia nigra. Inflammation and oxidative stress contribute significantly to its progression. This study assessed the effects of voluntary exercise and Ginkgo biloba supplementation on oxidative stress in a PD mouse model, using thirty female C57BL/6 mice induced with PD via MPTP. Experimental: The study included a pre-test and post-test phase with an eight-week intervention. Mice in the exercise group used spinning wheels daily, while those in the Ginkgo biloba group received 80 mg plant extract via gavage. A combination group followed both methods, and a control group received a placebo. Biochemical assessments were conducted after fasting, and results were analyzed with one-way ANOVA. Results: Findings showed that expression levels of SIRT1 and NRF2 as well as SOD concentration were significantly lower (P<0.05) in the PD model compared to control but increased after interventions. Malondialdehyde (MDA) levels were elevated in the PD group but decreased following the interventions, with the greatest improvements in the combination group, indicating a synergistic effect in alleviating Parkinson symptoms. Recommended applications/industries: Complimentary medicine identified Ginkgo biloba and voluntary exercise are recognized as effective methods to prevent and improve neurodegenerative disorder. Based on present results, Ginkgo biloba extract and voluntary exercise improved SIRT1 and NRF2 as well as SOD and MDA concentration in Parkinson condition. Furthermore, consuming the Ginkgo biloba along with voluntary exercise might recover oxidative stress pathway and regulate the hub genes networks.
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