Combining aerobic training and resveratrol can improve hippocampal UPRmt genes expression better than either alone in Alzheimer's rats
الموضوعات : Exercise Physiology and Performance
Elham Heydarzadeh
1
,
Kamal Azizbeigi
2
,
Khalid Mohamadzadeh Salamat
3
1 - Department of Physical Education, Sa.C., Islamic Azad University, Sanandaj, Iran.
2 - Department of Physical Education, Sa.C., Islamic Azad University, Sanandaj, Iran.
3 - Department of Physical Education, Sa.C., Islamic Azad University, Sanandaj, Iran.
الکلمات المفتاحية: Alzheimer's Disease, Exercise, Resveratrol, Mitochondrial Unfolded Protein Response ,
ملخص المقالة :
Background: Mitochondrial dysfunction are a key mechanism in the pathogenesis of Alzheimer's disease (AD). Both exercise and resveratrol (RSV) consumption have been identified as potential interventions against AD. The aim of this study was to evaluate the effects of aerobic exercise and RSV on hippocampal UPRmt in rats with AD.
Materials and Methods: In this experimental study, 35 male Wistar rats were divided into five groups: Normal (NO), Alzheimer's (AD), Alzheimer's-Training (ADT), Alzheimer's-Resveratrol (ADRSV), and Alzheimer's-Training-Resveratrol (ADTRSV). The supplement groups received 20 mg of RSV per kg of body weight orally during the intervention period. The aerobic exercise program involved running on a treadmill at speeds ranging from 6 to 18 meters per minute, performed 5 days a week for eight weeks.
Results: AD induction significantly decreased the expression of HSP10, HSP60, and HSP70 (p=0.0001). The expression of HSP60 and HSP70 was significantly increased in the ADT (p=0.024, p=0.041), ADRSV (p=0.029, p=0.046), and ADTRSV (p=0.0001, p=0.0001) groups compared to the AD group. Additionally, ADTRSV showed a greater increase in HSP60 and HSP70 expression compared to ADT (p=0.038, p=0.045) and ADRSV (p=0.032, p=0.040). A significant increase in HSP10 expression was observed in the ADT (p=0.032) and ADTRSV (p=0.0001) groups compared to the AD group, with ADTRSV showing higher levels of HSP10 expression compared to ADRSV (p=0.049).
Conclusion: Aerobic exercise and RSV can reduce neurodegeneration in AD rats by enhancing hippocampal UPRmt gene expression. The combination of exercise and RSV had a greater effect on UPRmt than either intervention alone.
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