Effect of combined exercise on adiponectin expression and selected metabolic indices: Investigating changes related to cardiovascular health and blood glucose control in elderly obese men
الموضوعات : Journal of Physical Activity and Hormones
Mina Safari
1
,
Ramin Shabani
2
,
Alireza Elmieh
3
1 - Department of Physical Education and Sport Sciences, Ra.C., Islamic Azad University, Rasht, Iran
2 - Department of Physical Education and Sport Sciences, Ra.C., Islamic Azad University, Rasht, Iran
3 - Department of Physical Education and Sport Sciences, Ra.C., Islamic Azad University, Rasht, Iran
الکلمات المفتاحية: Combined exercise, Adiponectin, Aging, Metabolic health,
ملخص المقالة :
Introduction: Aging and obesity are associated with metabolic and cardiovascular dysfunctions, partly due to impaired adipokine regulation and insulin sensitivity. This study aimed to investigate the effect of combined exercise on adiponectin expression and selected metabolic indices related to cardiovascular health and blood glucose control in elderly obese men.
Material & Methods: This quasi-experimental study with a pre-test–post-test design included 40 obese elderly men (mean age: 61.90 ± 2.84 years; BMI: 31.01 ± 1.53 kg/m²), who were randomly assigned to experimental (n = 20) and control (n = 20) groups. The experimental group participated in a combined exercise program (aerobic and resistance) for 16 weeks, three sessions per week, each lasting 90 minutes. Blood samples were collected 48 hours before and after the intervention to assess levels of adiponectin, insulin, HbA1c, cholesterol, and HDL. Data were analyzed using SPSS version 26 through paired t-tests and ANCOVA.
Results: The results demonstrated that combined exercise significantly increased adiponectin levels (P = 0.0001). The experimental group showed notable improvements in the adiponectin-to-insulin ratio (P = 0.0001) and the total cholesterol-to-HDL cholesterol ratio (P = 0.04), along with a reduction in HbA1c levels (P = 0.01). No significant changes were observed in the control group.
Conclusion: The findings suggest that combined exercise significantly increased adiponectin levels and improved metabolic markers, including the adiponectin-to-insulin and total-to-HDL cholesterol ratios. HbA1c levels also decreased, indicating better glycemic control.
1. Mohajan D, Mohajan HK. Obesity and its related diseases: a new escalating alarming in global health. Journal of Innovations in Medical Research. 2023;2(3):12-23.
2. Rohm TV, Meier DT, Olefsky JM, Donath MY. Inflammation in obesity, diabetes, and related disorders. Immunity. 2022;55(1):31-55. https://doi.org/10.1016/j.immuni.2022.06.014
3. Farkhondeh T, Llorens S, Pourbagher-Shahri AM, Ashrafizadeh M, Talebi M, Shakibaei M, et al. An overview of the role of adipokines in cardiometabolic diseases. Molecules. 2020;25(21):5218. https://doi.org/10.3390/molecules25215218
4. Zhao S, Kusminski CM, Scherer PE. Adiponectin, leptin and cardiovascular disorders. Circulation research. 2021;128(1):136-49. https://doi.org/10.1161/CIRCRESAHA.120.314510
5. Achari AE, Jain SK. Adiponectin, a therapeutic target for obesity, diabetes, and endothelial dysfunction. International journal of molecular sciences. 2017;18(6):1321. https://doi.org/10.3390/ijms18061321
6. Cohen KE, Katunaric B, SenthilKumar G, McIntosh JJ, Freed JK. Vascular endothelial adiponectin signaling across the life span. American Journal of Physiology-Heart and Circulatory Physiology. 2022;322(1):H57-H65. https://doi.org/10.1152/ajpheart.00602.2021
7. Khajebishak Y, Faghfouri AH, Soleimani A, Ilaei S, Peyrovi S, Madani S, et al. The potential relationship between serum irisin concentration with inflammatory cytokines, oxidative stress biomarkers, glycemic indices and lipid profiles in obese patients with type 2 diabetes mellitus: a pilot study. Journal of the ASEAN Federation of Endocrine Societies. 2023;38(1):45. https://doi.org/10.15605/jafes.038.01.10
8. Wolf D, Ley K. Immunity and inflammation in atherosclerosis. Circulation research. 2019;124(2):315-27. https://doi.org/10.1161/CIRCRESAHA.118.313591
9. McGee SL, Hargreaves M. Exercise adaptations: molecular mechanisms and potential targets for therapeutic benefit. Nature Reviews Endocrinology. 2020;16(9):495-505. https://doi.org/10.1038/s41574-020-0367-7
10. Ruegsegger GN, Booth FW. Health benefits of exercise. Cold Spring Harbor perspectives in medicine. 2018;8(7):a029694https://doi.org/10.1101/cshperspect.a029694
11. Nery C, De Moraes SRA, Novaes KA, Bezerra MA, Silveira PVDC, Lemos A. Effectiveness of resistance exercise compared to aerobic exercise without insulin therapy in patients with type 2 diabetes mellitus: a meta-analysis. Brazilian journal of physical therapy. 2017;21(6):400-15. https://doi.org/10.1016/j.bjpt.2017.05.007
12. Alizadeh Pahlavani H. Exercise therapy for people with sarcopenic obesity: myokines and adipokines as effective actors. Frontiers in endocrinology. 2022;13:811751. https://doi.org/10.3389/fendo.2022.811751
13. Kao H-H, Hsu H-S, Wu T-H, Chiang H-F, Huang H-Y, Wang H-J, et al. Effects of a single bout of short-duration high-intensity and long-duration low-intensity exercise on insulin resistance and adiponectin/leptin ratio. Obesity research & clinical practice. 2021;15(1):58-63. https://doi.org/10.1016/j.orcp.2020.10.003
14. Zhou Y, Wu W, Zou Y, Huang W, Lin S, Ye J, et al. Benefits of different combinations of aerobic and resistance exercise for improving plasma glucose and lipid metabolism and sleep quality among elderly patients with metabolic syndrome: a randomized controlled trial. Endocrine journal. 2022;69(7):819-30. https://doi.org/10.1507/endocrj.EJ21-0528
15. Wrench E, Rattley K, Lambert JE, Killick R, Hayes LD, Lauder RM, et al. There is no dose–response relationship between the amount of exercise and improvement in HbA1c in interventions over 12 weeks in patients with type 2 diabetes: a meta-analysis and meta-regression. Acta Diabetologica. 2022;59(11):1399-415. https://doi.org/10.1007/s00592-022-01969-6
16. Pan B, Ge L, Xun Y-q, Chen Y-j, Gao C-y, Han X, et al. Exercise training modalities in patients with type 2 diabetes mellitus: a systematic review and network meta-analysis. International Journal of Behavioral Nutrition and Physical Activity. 2018;15:1-14. https://doi.org/10.1186/s12966-018-0761-7
17. Qian Z, Ping L, Dongming X, Xuelin Z. Slow-velocity eccentric-only resistance training improves symptoms of type 2 diabetic mellitus patients by regulating plasma MMP-2 and-9. Medicine. 2024;103(29):e38855. https://doi.org/10.1097/MD.0000000000038855
18. Safari M, Shabani R, Elmieh A. The Effect of Combined Aerobic-Resistance Exercise on Interleukin-10 Levels, Vascular Endothelial Growth Factor, Neutrophil-to-Lymphocyte Ratio, Cognitive and Walking Functions in Obese Elderly Men. Journal of Mazandaran University of Medical Sciences. 2025;35(243):39-52.
19. Hejazi K, Ghahremani Moghaddam M, Darzabi T. Effects of an 8-week aerobic exercise program on some indicators of oxidative stress in elderly women. Iranian Journal of Ageing. 2019;13(4):506-17.
20. Schumacher LM, Thomas JG, Raynor HA, Rhodes RE, Bond DS. Consistent morning exercise may be beneficial for individuals with obesity. Exercise and sport sciences reviews. 2020;48(4):201-8. https://doi.org/10.1249/JES.0000000000000230
21. Alabdulwahab SS, Ahmad F, Singh H. Effects of functional limb overloading on symmetrical weight bearing, walking speed, perceived mobility, and community participation among patients with chronic stroke. Rehabilitation research and practice. 2015;2015(1):241519. https://doi.org/10.1155/2015/241519
22. Zhang K, Ma Y, Luo Y, Song Y, Xiong G, Ma Y, et al. Metabolic diseases and healthy aging: identifying environmental and behavioral risk factors and promoting public health. Frontiers in public health. 2023;11:1253506. https://doi.org/10.3389/fpubh.2023.1253506
23. Zhang H. Growth Differentiation Factor-15 Is a Contraction-Induced Myokine that Maintains Glucose Homeostasis in Obesity and Type 2 Diabetes: Case Western Reserve University; 2021.
24. Engin A. Adiponectin Resistance in Obesity: Adiponectin Leptin/Insulin Interaction. Obesity and Lipotoxicity. 2024:431-62. https://doi.org/10.1007/978-3-031-38208-4_14
25. Zheng Y, Qi L. Personalized Diet and Lifestyle Interventions on Lipids and Lipoproteins. Handbook of lipids in human function: Elsevier; 2016. p. 1-20. https://doi.org/10.1016/B978-0-12-805376-8.00001-9
26. Song R, Hu M, Qin X, Qiu L, Wang P, Zhang X, et al. The roles of lipid metabolism in the pathogenesis of chronic diseases in the elderly. Nutrients. 2023;15(15):3433. https://doi.org/10.3390/nu15153433
