Assessment of Oxidative Stress, Cardiac Biomarkers, and Platelet Indices in Acute Myocardial Infarction: A Case-Control Study
الموضوعات :Ali Mohammed Brakat 1 , Hassan Sarhan Sachit 2 , Ghassan Jabbar Auda 3 , Adnan Taan Thamer 4 , Raed Fanoukh Aboqader Al-Aouadi 5
1 - Consultant Microbiologist, Department of Microbiology and Immunology, College of Medicine, Al-Ayen Iraqi University, AUIQ, An Nasiriyah, Iraq
2 - Lecturer of Microbiology and Immunology Department of Microbiology and Immunology, College of Medicine, Al-Ayen Iraqi University, AUIQ, An Nasiriyah, Iraq
3 - Professor Dr. of Internal Medicine and intervention Cardiology, Director of Al-Rabea Cardiac Center, Dean of College of Medicine, Al-Ayen Iraqi University, AUIQ, An Nasiriyah, Iraq
4 - Professor Dr. of Internal Medicine, College of Medicine, Al-Ayen Iraqi University, AUIQ, An Nasiriyah, Iraq
5 - College of Medicine, Al-Ayen Iraqi University, AUIQ, An Nasiriyah, Iraq
الکلمات المفتاحية: Acute Myocardial Infarction, Oxidative Stress, Cardiac Biomarkers, CK-MB, hs-CRP, Platelet Indices, Malondialdehyde (MDA),
ملخص المقالة :
Acute myocardial infarction (AMI) is a pathological condition primarily affecting the coronary arteries. The future risk of cardiac events is closely linked to abnormalities in heart biomarkers. The generation of free radicals due to oxidative stress leads to the oxidation of low-density lipoprotein (LDL), which subsequently contributes to the formation of atherosclerosis. In cases where necrosis occurs as a result of coronary artery occlusion, there is a notable increase in CK-MB levels. This study aimed to evaluate the levels of CK-MB, high-sensitivity C-reactive protein (hs-CRP), platelet indices, and malondialdehyde (MDA) in patients with acute myocardial infarction. A total of 19 patients with AMI who consulted outpatient clinics and were referred to the Al-Rabea Cardiac Center for further management were included in the study, along with 19 healthy controls. Blood samples (5 ml) were collected from each participant through venipuncture. After centrifugation, serum was separated and analyzed for lipid parameters (triglycerides, total cholesterol, LDL, high-density lipoprotein (HDL), and very low-density lipoprotein (VLDL)), cardiac biomarkers (hs-CRP and CK-MB), and oxidative stress markers (malondialdehyde, MDA). The results indicated a significant increase in MDA, heart biomarkers, and lipid parameters in the AMI group compared to the control group, with the exception of HDL, which was found to be significantly decreased. Lipid peroxidation, as indicated by elevated MDA levels, was found to be closely associated with AMI. Furthermore, CK-MB, hs-CRP, and platelet parameters (PDW, platelet count, and MPV) could serve as valuable biomarkers for the diagnosis and understanding of the pathogenesis of AMI.
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