مروری بر کاربرد پروبیوتیک ها ومتابولیت های آن در درمان بیماریها
الموضوعات : Biotechnological Journal of Environmental Microorganisms
محدثه لاری پور
1
,
حمیده کربلایی حیدر
2
,
کیمیا بسیجی
3
,
مائده ابراهیمی
4
1 - گروه میکروبیولوژی ، دانشکده علوم پایه ، واحد تهران شمال ، دانشگاه آزاد اسلامی ، تهران ، ایران
2 - دانش آموخته ارشد بیوتکنولوژی، دانشکده علوم زیستی، گروه بیوتکنولوژی،دانشگاه آزاد اسلامی ،واحدتهران شمال، تهران، ایران
3 - دانش آموخته ارشد میکروبیولوژی، دانشکده علوم زیستی، گروه بیوتکنولوژی،دانشگاه آزاد اسلامی ،واحدتهران شمال، تهران، ایران
4 - دانش آموخته ارشد میکروبیولوژی، دانشکده علوم زیستی، گروه بیوتکنولوژی،دانشگاه آزاد اسلامی ،واحدتهران شمال، تهران، ایران
الکلمات المفتاحية: پروبیوتیک, سین بیوتیک, پری بیوتیک, پست بیوتیک,
ملخص المقالة :
دستگاه گوارش انسان حاوی میکروبیوتای غنی و پیچیده ای است که در عملکرد دستگاه گوارشی، فرایندهای ایمونولوژیک و درمسیر برخی از بیماری ها از جمله دیس بیوز نقش مهمی را ایفا می کند. بر طبق تحقیقات مجموعه میکروبیوتای دستگاه گوارش می تواند، بر روی کاهش یا افزایش جمعیت میکروبیوم پوست، دستگاه عصبی و قسمتهای دیگر بدن انسان تأثیر گذار باشد. مصرف مکملهای غذایی فراسودمند به عنوان یک استراتژی بالقوه و امیدوارکننده برای تنظیم میکروبیوتای روده وبهبود بیماری های تحث تأثیر آن در حال ظهور است. انواع مکمل های پروبیوتیک می تواند شامل مخمرها، باکتری ها و انواع پری بیوتیک شامل پلی ساکارید های غیر قابل هضم با منشاء گیاهی، میکروبی، قارچهای کلاهدارو جلبکها باشند. همراه شدن پروبیوتیک ها و پری بیوتیکها منجر به تولید فراورده های سینبیوتیک با اثرات قوی تر در ارتقاء سلامت انسان می شود. علاوه بر این موارد، پست بیوتیک ها محصولات جانبی متابولیک آزاد شده از پروبیوتیک ها می باشند و پس از تجزیه باکتری با اثرات سلامتی زیادی مانند تنظیم سلامت روده و تقویت سیستم ایمنی، مانند پروبیوتیک‌ها مورد استفاده قرار گرفته اند. تا به امروز در مطالعات انجام شده، اثرات افزایش پروبیوتیک های روده و کاهش میکروارگانیسم های بیماریزا پری بیوتیک و اثرات ضد سرطانی ، التهابی و ایمونومدولاتوری پست بیوتیک ها و سین بیوتیک ها بر روی میکروبیوم دستگاه گوارشی اثبات شده لذا تهیه مکمل های فراسودمند ومصرف آنها افزایش پیدا کرده است.
Resources
1. Arihara, K., Strategies for designing novel functional meat products. Meat science, 2006. 74(1): p. 219-229.
2. Daneshmand, A., et al., Effect of oyster mushroom (Pleurotus ostreatus) with and without probiotic on growth performance and some blood parameters of male broilers. Animal feed science and technology, 2011. 170(1-2): p. 91-96.
3. Cheung, M.K., et al., A Review of the Effects of Natural Compounds, Medicinal Plants, and Mushrooms on the Gut Microbiota in Colitis and Cancer. Front Pharmacol, 2020. 11: p. 744.
4. Valdes, A.M., et al., Role of the gut microbiota in nutrition and health. Bmj, 2018. 361.
5. Anggeraini, A.S., et al., Effects of synbiotic supplement on body weight and fasting blood glucose levels in obesity: A randomized placebo-controlled trial. Annals of Medicine and Surgery, 2021. 68: p. 102548.
6. Czerucka, D., T. Piche, and P. Rampal, yeast as probiotics–Saccharomyces boulardii. Alimentary pharmacology & therapeutics, 2007. 26(6): p. 767-778.
7. Gāliņa, D., L. Ansonska, and A. Valdovska, Effect of probiotics and herbal products on intestinal histomorphological and immunological development in piglets. Veterinary medicine international, 2020. 2020.
8. Wasser, S.P., et al., Dietary supplements from medicinal mushrooms: diversity of types and variety of regulations. International Journal of Medicinal Mushrooms, 2000. 2(1).
9. Aida, F., et al., Mushroom as a potential source of prebiotics: a review. Trends in Food Science & Technology, 2009. 20(11-12): p. 567-575.
10. Shokryazdan, P., et al., Probiotics: from isolation to application. Journal of the American College of Nutrition, 2017. 36(8): p. 666-676.
11. Markowiak, P. and K. Śliżewska, Effects of Probiotics, Prebiotics, and Synbiotics on Human Health. Nutrients, 2017. 9(9).
12. Williams, N.T., Probiotics. American Journal of Health-System Pharmacy, 2010. 67(6): p. 449-458.
13. Ishibashi, N., Yamazaki S. Probiotics and safety. Am J Clin Nutr, 2001. 73: p. 465S-470S.
14. Hessari, H., et al., Probiotics and therapeutic applications. Laboratory and Diagnosis, 2019. 10(42): p. 61-66.
15. Xiang, Q., et al., Effects of different probiotics on laying performance, egg quality, oxidative status, and gut health in laying hens. Animals, 2019. 9(12): p. 1110.
16. Higgins, J., et al., Temporal effects of lactic acid bacteria probiotic culture on Salmonella in neonatal broilers. Poultry Science, 2007. 86(8): p. 1662-1666.
17. Kurian, S.J., et al., Probiotics in Prevention and Treatment of COVID-19: Current Perspective and Future Prospects. Archives of medical research, 2021.
18. Amirani, E., et al., The effects of probiotic supplementation on mental health, biomarkers of inflammation and oxidative stress in patients with psychiatric disorders: A systematic review and meta-analysis of randomized controlled trials. Complementary therapies in medicine, 2020. 49: p. 102361.
19. Cristofori, F., et al., Anti-inflammatory and immunomodulatory effects of probiotics in gut inflammation: a door to the body. Frontiers in Immunology, 2021. 12: p. 178.
20. Cremonini, F., et al., Meta‐analysis: the effect of probiotic administration on antibiotic‐associated diarrhoea. Alimentary pharmacology & therapeutics, 2002. 16(8): p. 1461-1467.
21. McFarland, L.V., Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease. Official journal of the American College of Gastroenterology| ACG, 2006. 101(4): p. 812-822.
22. Hickson, M., et al., Use of probiotic Lactobacillus preparation to prevent diarrhoea associated with antibiotics: randomised double blind placebo controlled trial. Bmj, 2007. 335(7610): p. 80.
23. Van Niel, C.W., et al., Lactobacillus therapy for acute infectious diarrhea in children: a meta-analysis. Pediatrics, 2002. 109(4): p. 678-684.
24. Allen, S.J., et al., Probiotics for treating acute infectious diarrhoea. Cochrane Database of Systematic Reviews, 2010(11).
25. Guandalini, S., et al., Lactobacillus GG administered in oral rehydration solution to children with acute diarrhea: a multicenter European trial. Journal of pediatric gastroenterology and nutrition, 2000. 30(1): p. 54-60.
26. Islam, S.U., Clinical uses of probiotics. Medicine, 2016. 95(5).
27. McFarland, L.V. and S. Dublin, Meta-analysis of probiotics for the treatment of irritable bowel syndrome. World journal of gastroenterology: WJG, 2008. 14(17): p. 2650.
28. Choung, R.S. and G. Locke 3rd, Epidemiology of IBS. Gastroenterology Clinics of North America, 2011. 40(1): p. 1-10.
29. Mulder, D.J., et al., A tale of two diseases: the history of inflammatory bowel disease. Journal of Crohn's and Colitis, 2014. 8(5): p. 341-348.
30. Kirsner, J.B., Historical origins of current IBD concepts. World journal of gastroenterology, 2001. 7(2): p. 175.
31. Jakubczyk, D., K. Leszczyńska, and S. Górska, The effectiveness of probiotics in the treatment of inflammatory bowel disease (IBD)—a critical review. Nutrients, 2020. 12(7): p. 1973.
32. Rautava, S., M. Kalliomäki, and E. Isolauri, Probiotics during pregnancy and breast-feeding might confer immunomodulatory protection against atopic disease in the infant. Journal of allergy and clinical immunology, 2002. 109(1): p. 119-121.
33. Papista, C., et al., Gluten induces coeliac-like disease in sensitised mice involving IgA, CD71 and transglutaminase 2 interactions that are prevented by probiotics. Laboratory investigation, 2012. 92(4): p. 625-635.
34. Olivares, M., M. Laparra, and Y. Sanz, Oral administration of Bifidobacterium longum CECT 7347 modulates jejunal proteome in an in vivo gliadin-induced enteropathy animal model. Journal of proteomics, 2012. 77: p. 310-320.
35. de Almeida, N.E.C., et al., Digestion of Intact Gluten Proteins by Bifidobacterium Species: Reduction of Cytotoxicity and Proinflammatory Responses. Journal of Agricultural and Food Chemistry, 2020. 68(15): p. 4485-4492.
36. Limketkai, B.N., et al., Probiotics for induction of remission in Crohn's disease. Cochrane Database of Systematic Reviews, 2020(7).
37. Shams, K., M. Larypoor, and J. Salimian, The immunomodulatory effects of Candida albicans isolated from the normal gastrointestinal microbiome of the elderly on colorectal cancer. Medical Oncology, 2021. 38(12): p. 1-12.
38. Banik, A., et al., Fungal probiotics: Opportunity, challenge, and prospects, in Recent Advancement in White Biotechnology Through Fungi. 2019, Springer. p. 101-117.
39. Mahyuddin, P. and M. Winugroho, Effect of combination of yeast (Saccharomyces cerevisae+ Candida utilis) and herbs supplementation in finishing diet on carcass characteristics of beef cattle. Journal of the Indonesian Tropical Animal Agriculture, 2010. 35(4): p. 251-256.
40. Oak, S.J. and R. Jha, The effects of probiotics in lactose intolerance: A systematic review. Crit Rev Food Sci Nutr, 2019. 59(11): p. 1675-1683.
41. Luyer, B.l., G. Makhoul, and J. Duhamel, A multicentric study of a lactose free formula supplemented with Saccharomyces boulardii in children with acute diarrhea. Archives de Pédiatrie, 2010. 17(5): p. 459-465.
42. Saber, A., et al., Secretion metabolites of probiotic yeast, Pichia kudriavzevii AS-12, induces apoptosis pathways in human colorectal cancer cell lines. Nutrition research, 2017. 41: p. 36-46.
43. Greppi, A., et al., Potential probiotic Pichia kudriavzevii strains and their ability to enhance folate content of traditional cereal-based African fermented food. Food microbiology, 2017. 62: p. 169-177.
44. Carro, L. and I. Nouioui, Taxonomy and systematics of plant probiotic bacteria in the genomic era. AIMS microbiology, 2017. 3(3): p. 383.
45. Stickel, F. and D. Shouval, Hepatotoxicity of herbal and dietary supplements: an update. Arch Toxicol, 2015. 89(6): p. 851-65.
46. Cohen, P.A. and E. Ernst, Safety of herbal supplements: a guide for cardiologists. Cardiovascular therapeutics, 2010. 28(4): p. 246-253.
47. Chrysant, S., The clinical significance and costs of herbs and food supplements used by complementary and alternative medicine for the treatment of cardiovascular diseases and hypertension. Journal of human hypertension, 2016. 30(1): p. 1-6.
48. Lee, A.N. and V.P. Werth, Activation of autoimmunity following use of immunostimulatory herbal supplements. Archives of Dermatology, 2004. 140(6): p. 723-727.
49. Adom, M.B., et al., Chemical constituents and medical benefits of Plantago major. Biomedicine & Pharmacotherapy, 2017. 96: p. 348-360.
50. Nematgorgani, S., et al., Effects of Urtica dioica leaf extract on inflammation, oxidative stress, ESR, blood cell count and quality of life in patients with inflammatory bowel disease. Journal of Herbal Medicine, 2017. 9: p. 32-41.
51. Saddiqe, Z., I. Naeem, and A. Maimoona, A review of the antibacterial activity of Hypericum perforatum L. Journal of ethnopharmacology, 2010. 131(3): p. 511-521.
52. Nissen, L., et al., Prebiotic potential and bioactive volatiles of hemp byproduct fermented by lactobacilli. LWT, 2021: p. 112201.
53. Doron, S. and D.R. Snydman, Risk and safety of probiotics. Clinical Infectious Diseases, 2015. 60(suppl_2): p. S129-S134.
54. Van den Nieuwboer, M., et al., Probiotic and synbiotic safety in infants under two years of age. Beneficial microbes, 2014. 5(1): p. 45-60.
55. Sanders, M.E., et al., Safety assessment of probiotics for human use. Gut microbes, 2010. 1(3): p. 164-185.
56. Snydman, D.R., The safety of probiotics. Clinical infectious diseases, 2008. 46(Supplement_2): p. S104-S111.
57. Horwitch, C.A., et al., Lactobacillemia in three patients with AIDS. Clinical infectious diseases, 1995. 21(6): p. 1460-1462.
58. Bhakta, M. and P. Kumar, Mushroom polysaccharides as a potential prebiotics. Int. J. Health Sci. Res, 2013. 3(8): p. 77-84.
59. Davani-Davari, D., et al., Prebiotics: definition, types, sources, mechanisms, and clinical applications. Foods, 2019. 8(3): p. 92.
60. Johnson-Henry, K.C., et al., Probiotics, prebiotics, and synbiotics for the prevention of necrotizing enterocolitis. Advances in nutrition, 2016. 7(5): p. 928-937.
61. Khan, S.H., N. Mukhtar, and J. Iqbal, Role of Mushroom as Dietary Supplement on Performance of Poultry. J Diet Suppl, 2019. 16(5): p. 611-624.
62. Chuang, W.Y., Y.C. Hsieh, and T.T. Lee, The Effects of Fungal Feed Additives in Animals: A Review. Animals (Basel), 2020. 10(5).
63. Wu, L., et al., Chemical structure and inhibition on α-glucosidase of the polysaccharides from Cordyceps militaris with different developmental stages. International journal of biological macromolecules, 2020. 148: p. 722-736.
64. Bulam, S., N.Ş. Üstün, and A. Pekşen, Health benefits of Ganoderma lucidum as a medicinal mushroom. Turkish Journal of Agriculture-Food Science and Technology, 2019. 7(sp1): p. 84-93.
65. Xu, J.-W., W. Zhao, and J.-J. Zhong, Biotechnological production and application of ganoderic acids. Applied microbiology and biotechnology, 2010. 87(2): p. 457-466.
66. Yamin, S., et al., Effect of Ganoderma lucidum polysaccharides on the growth of Bifidobacterium spp. as assessed using Real-time PCR. International Food Research Journal, 2012. 19(3): p. 1199.
67. Delzenne, N.M. and L.B. Bindels, Ganoderma lucidum, a new prebiotic agent to treat obesity? Nature reviews Gastroenterology & hepatology, 2015. 12(10): p. 553-554.
68. Yasrebi, N., A.S. Hatamian Zarmi, and M. Larypoor, Optimization of Chitosan Production from Iranian Medicinal Fungus Trametes-Versicolor by Taguchi Method and Evaluation of Antibacterial Properties. Iranian Journal of Medical Microbiology, 2020. 14(3): p. 186-200.
69. Zeynali, M., A. Hatamian-Zarmi, and M. Larypoor, Evaluation of Chitin-Glucan Complex Production in Submerged Culture of Medicinal Mushroom of Schizophilum commune: Optimization and Growth Kinetic. Iranian Journal of Medical Microbiology, 2019. 13(5): p. 406-424.
70. Benkeblia, N., Ganoderma lucidum polysaccharides and Terpenoids: profile and health benefits. J Food Nutr Diet, 2015. 1: p. 1-6.
71. Ferreira, I.C., et al., Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities. Phytochemistry, 2015. 114: p. 38-55.
72. Lee, S.-M. and C.-M. Ryu, Algae as New Kids in the Beneficial Plant Microbiome. Frontiers in Plant Science, 2021. 12: p. 91.
73. Ścieszka, S. and E. Klewicka, Algae in food: A general review. Critical reviews in food science and nutrition, 2019. 59(21): p. 3538-3547.
74. Cherry, P., et al., Prebiotics from seaweeds: An ocean of opportunity? Marine drugs, 2019. 17(6): p. 327.
75. Ricigliano, V.A. and M. Simone-Finstrom, Nutritional and prebiotic efficacy of the microalga Arthrospira platensis (spirulina) in honey bees. Apidologie, 2020. 51(5): p. 898-910.
76. Bruzzese, E., et al., Impact of prebiotics on human health. Digestive and Liver Disease, 2006. 38: p. S283-S287.
77. Yaqoob, M., et al., The potential mechanistic insights and future implications for the effect of prebiotics on poultry performance, gut microbiome, and intestinal morphology. Poultry Science, 2021: p. 101143.
78. Elgeddawy, S.A., et al., Effects of the dietary inclusion of a probiotic or prebiotic on florfenicol pharmacokinetic profile in broiler chicken. Journal of animal physiology and animal nutrition, 2020. 104(2): p. 549-557.
79. Gowrishankar, S., A. Kamaladevi, and S.K. Pandian, Prebiotics Mechanism of Action: An Over View, in Advances in Probiotics. 2021, Elsevier. p. 137-148.
80. Khalil, N.A., et al., Prospective evaluation of probiotic and prebiotic supplementation on diabetic health associated with gut microbiota. Food Bioscience, 2021: p. 101149.
81. Currò, D., et al., Probiotics, fibre and herbal medicinal products for functional and inflammatory bowel disorders. British journal of pharmacology, 2017. 174(11): p. 1426-1449.
82. Schrezenmeir, J. and M. de Vrese, Probiotics, prebiotics, and synbiotics—approaching a definition. The American journal of clinical nutrition, 2001. 73(2): p. 361s-364s.
83. Roselli, M. and A. Finamore, Use of synbiotics for ulcerative colitis treatment. Current clinical pharmacology, 2020. 15(3): p. 174-182.
84. Tang, S.G.H., et al., Chemical compositions of egg yolks and egg quality of laying hens fed prebiotic, probiotic, and synbiotic diets. Journal of food science, 2015. 80(8): p. C1686-C1695.
85. Altun, H.K., E.A. Yıldız, and M. Akın, Effects of synbiotic therapy in mild-to-moderately active ulcerative colitis: A randomized placebo-controlled study. The Turkish Journal of Gastroenterology, 2019. 30(4): p. 313.
88. Dilli, D., et al., The propre-save study: effects of probiotics and prebiotics alone or combined on necrotizing enterocolitis in very low birth weight infants. The Journal of pediatrics, 2015. 166(3): p. 545-551. e1.
87. Sreenivasa, B., et al., Role of synbiotics in the prevention of necrotizing enterocolitis in preterm neonates: a randomized controlled trial. Int J Contemp Pediatr, 2015. 2(2): p. 127-30.
88. Wang, Y., et al., Probiotics and fructo-oligosaccharide intervention modulate the microbiota-gut brain axis to improve autism spectrum reducing also the hyper-serotonergic state and the dopamine metabolism disorder. Pharmacological Research, 2020. 157: p. 104784.
89. Noll, M., et al., Improvement of Atopic Dermatitis by Synbiotic Baths. Microorganisms, 2021. 9(3): p. 527.
90. Dehghani, H., et al., Synbiotic supplementations for azotemia in patients with chronic kidney disease: a randomized controlled trial. Iranian journal of kidney diseases, 2016. 10(6): p. 351.
91. Ban, Q., et al., Effects of a synbiotic yogurt using monk fruit extract as sweetener on glucose regulation and gut microbiota in rats with type 2 diabetes mellitus. Journal of dairy science, 2020. 103(4): p. 2956-2968.
92. Żółkiewicz, J., et al., Postbiotics—a step beyond pre-and probiotics. Nutrients, 2020. 12(8): p. 2189.
93. Wegh, C.A., et al., Postbiotics and their potential applications in early life nutrition and beyond. International journal of molecular sciences, 2019. 20(19): p. 4673.
94. Tsilingiri, K. and M. Rescigno, Postbiotics: what else? Beneficial microbes, 2013. 4(1): p. 101-107.
95. Makino, S., et al., Enhanced natural killer cell activation by exopolysaccharides derived from yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1. Journal of dairy science, 2016. 99(2): p. 915-923.
96. Vrzáčková, N., T. Ruml, and J. Zelenka, Postbiotics, Metabolic Signaling, and Cancer. Molecules, 2021. 26(6): p. 1528.
97. Chuah, L.-O., et al., Postbiotic metabolites produced by Lactobacillus plantarum strains exert selective cytotoxicity effects on cancer cells. BMC complementary and alternative medicine, 2019. 19(1): p. 1-12.
98. Morniroli, D., et al., Postbiotic Supplementation for Children and Newborn’s Health. Nutrients, 2021. 13(3): p. 781.
99. De Marco, S., et al., Probiotic cell-free supernatants exhibited anti-inflammatory and antioxidant activity on human gut epithelial cells and macrophages stimulated with LPS. Evidence-Based Complementary and Alternative Medicine, 2018. 2018.
