The effect of a period of combined training on the quality of life, cancer markers, aerobic capacity, type II diabetic patients after breast cancer surgery
الموضوعات : Journal of Physical Activity and HormonesNasibeh Ezeddin 1 , mona Mehdizadeh Haghighi 2 , pouran Akbari 3 , رامین شعبانی 4
1 - Department of physical Education and sport sciences,Rasht Branch,Islamic Azad University,Rasht,Iran
2 - Ph.D. Candidate, Exercise Physiology, Department of Physical Education and Sports Science, Rasht Branch, Islamic Azad University, Rasht, Iran
3 - M.A, exercise physiology, Department of Physical Education and Sport Sciences,Faculty of Humanities,Rasht Branch, Islamic Azad University, Iran.
4 - دانشگاه آزاد اسلامی واحد رشت- معاون پژوهشی
الکلمات المفتاحية: Breast Cancer, Diabetes, Quality of Life, Combined Exercise Training ,
ملخص المقالة :
Aim: The principle aim of this study was to investigate the effect of a period of combined training on the quality of life, cancer markers, aerobic capacity, and type II diabetic patients after breast cancer surgery.
Methods: The subjects were 30 women with cancer and type ll diabetes (mean age 50.53 ± 7.62 and weight 69.20 ± 19.14) who were selected initial screening and were divided into two groups, experimental group and control group. The aerobic-resistance training consisted of 3 sessions per week for 8 weeks. The resistance training were performed using Pilates cavities and aerobic exercises with a maximum heart rate of 50-70% and each intervention session lasted 60 minutes. The quality of life variables were assessed using the WHO-QI questionnaire, CA- 15-3 markers, CEA and aerobic power. In order to compare the pre-test and posttest results in each group was used the statistical correlated t-test, and the independent t test was used to compare the results of the two groups. The significance level was determined as P <0.05.
Findings: The results indicated that there is a significant difference in the variables of quality of life between the two groups. The results also demonstrated that there is a significant difference in the cancer markers in the CA15-3 variable among the two research groups, however, this difference was not significant in CEA markers .Aerobic endurance of the subjects did not show significant difference between the experimental and control groups after 8 weeks of combined exercise.
Conclusion: It can be concluded that 8 weeks of combined training in women with type ll diabetes after breast cancer surgery were effective on the quality of life, but it was unchanged in case of the cancer markers, the decreased CA15-3 variable and the CEA marker.
1. Forbes JM, Cooper ME. Mechanisms of diabetic complications. Physiological reviews. 2013;93(1):137-88.
2. Rosai J. Rosai and Ackerman's surgical pathology e-book: Elsevier Health Sciences; 2011.
3. Allred DC, Bustamante MA, Daniel CO, Gaskill HV, Cruz AB. Immunocytochemical analysis of estrogen receptors in human breast carcinomas: evaluation of 130 cases and review of the literature regarding concordance with biochemical assay and clinical relevance. Archives of Surgery. 1990;125(1):107-13.
4. Pertschuk LP, Kim DS, Nayer K, Feldman JG, Eisenberg KB, Carter AC, et al. Immunocytochemical estrogen and progestin receptor assays in breast cancer with monoclonal antibodies. Histopathologic, demographic, and biochemical correlations and relationship to endocrine response and survival. Cancer. 1990;66(8):1663-70.
5. Hinshelwood RA, Clark SJ. Breast cancer epigenetics: normal human mammary epithelial cells as a model system. Journal of molecular medicine. 2008;86:1315-28.
6. Kheirolomoom A, Silvestrini MT, Ingham ES, Mahakian LM, Tam SM, Tumbale SK, et al. Combining activatable nanodelivery with immunotherapy in a murine breast cancer model. Journal of Controlled Release. 2019;303:42-54.
7. Ruddy KJ, Ganz PA. Treatment of nonmetastatic breast cancer. Jama. 2019;321(17):1716-7.
8. Hupfeld CJ, Courtney CH, Olefsky JM. Type 2 diabetes mellitus: etiology, pathogenesis, and natural history. Endocrinology Adult and Pediatric: Diabetes Mellitus and Obesity E-Book. 2013:223-45.
9. Shabani R, Jalali Z, Nazari M. Effects of concurrent strength and aerobic training on blood glucose homeostasis and lipid profile in females with overweight and obesity. Zahedan Journal of Research in Medical Sciences. 2018;20(4).
10. Alberti KGMM, Zimmet P, Shaw J. Metabolic syndrome—a new world‐wide definition. A consensus statement from the international diabetes federation. Diabetic medicine. 2006;23(5):469-80.
11. Alberti KGMM, Zimmet P, Shaw J. International Diabetes Federation: a consensus on Type 2 diabetes prevention. Diabetic Medicine. 2007;24(5):451-63.
12. Liao S, Li J, Wei W, Wang L, Zhang Y, Li J, et al. Association between diabetes mellitus and breast cancer risk: a meta-analysis of the literature. Asian Pac J Cancer Prev. 2011;12(4):1061-5.
13. Larsson SC, Mantzoros CS, Wolk A. Diabetes mellitus and risk of breast cancer: a meta‐analysis. International journal of cancer. 2007;121(4):856-62.
14. Farhood B, Geraily G, Alizadeh A. Incidence and mortality of various cancers in Iran and compare to other countries: a review article. Iranian journal of public health. 2018;47(3):309.
15. Shamshirian A, Heydari K, Shams Z, Aref AR, Shamshirian D, Tamtaji OR, et al. Breast cancer risk factors in Iran: a systematic review & meta-analysis. Hormone molecular biology and clinical investigation. 2020;41(4):20200021.
16. Ronckers CM, Erdmann CA, Land CE. Radiation and breast cancer: a review of current evidence. Breast Cancer Research. 2004;7:1-12.
17. Tsitsi T, Charalambous A, Papastavrou E, Raftopoulos V. Effectiveness of a relaxation intervention (progressive muscle relaxation and guided imagery techniques) to reduce anxiety and improve mood of parents of hospitalized children with malignancies: A randomized controlled trial in Republic of Cyprus and Greece. European Journal of Oncology Nursing. 2017;26:9-18.
18. de Souto Barreto P, Delrieu J, Andrieu S, Vellas B, Rolland Y, editors. Physical activity and cognitive function in middle-aged and older adults: an analysis of 104,909 people from 20 countries. Mayo Clinic Proceedings; 2016: Elsevier.
19. Jeffs E, Wiseman T. Randomised controlled trial to determine the benefit of daily home-based exercise in addition to self-care in the management of breast cancer-related lymphoedema: a feasibility study. Supportive Care in Cancer. 2013;21:1013-23.
20. Ikeda K, Ogawa Y, Kajino C, Deguchi S, Kurihara S, Tashima T, et al. The influence of axillary reverse mapping related factors on lymphedema in breast cancer patients. European Journal of Surgical Oncology (EJSO). 2014;40(7):818-23.
21. Barcenas CH, Wells J, Chong D, French J, Looney SW, Samuel TA. Race as an independent risk factor for breast cancer survival: breast cancer outcomes from the medical college of georgia tumor registry. Clinical breast cancer. 2010;10(1):59-63.
22. Esfahbodi A, Fathi M, Rahimi GRM. Changes of CEA and CA15-3 biomarkers in the breast cancer patients following eight weeks of aerobic exercise. Basic & Clinical Cancer Research. 2017;9(4):4-12.
23. Koulaei M, Ezeddin N, Shabani A, Hedayati M. The effect of combined exercise training on Body composition, Upper limb Range of motion, Shoulder pain, and Glucose homeostasis in type II diabetic patients after breast cancer surgery.
