Electrocatalytic Determination of Captopril on Gold Nanoparticle-Modified Carbon Paste Electrode.

الموضوعات : فصلنامه نانوساختارهای اپتوالکترونیکی

Mohamad Ali Zare ¹ (Young Researchers and Elite Club, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran)
Omran Moradlou ² (Department of Chemistry, College of Sciences, Alzahra University, Tehran, Iran)
Behjat Tahmasebi ³ (Young Researchers and Elite Club, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran.)
Maryam Iranpour ⁴ (Department of Chemistry, Shiraz Branch, Islamic Azad University, Shiraz, Iran)
Parisa Farashi ⁵ (Young Researchers and Elite Club, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran.)

تاريخ الإرسال : 06 الثلاثاء , ربيع الأول, 1443 تاريخ التأكيد : 06 الجمعة , صفر, 1444 تاريخ الإصدار : 05 السبت , ربيع الأول, 1444

الکلمات المفتاحية: Electrochemical, Determination, Captopril, Gold Nanoparticle,

ملخص المقالة :

The electrochemical behavior of captopril at the surface of a carbon-paste electrode (CPE) modified with gold nanoparticles (GNPs) is described. The prepared electrode shows an excellent electrocatalytic activity toward the oxidation of captopril, which is leading to marked considerable improvement of sensitivity. Whereas at the surface of unmodified electrode an electrochemical activity for captopril cannot be observed, a very sharp anodic wave with an anodic peak potential about 1.0V (versus Ag/AgCl) is obtained using the prepared modified electrode. Captopril oxidation on CPE/GNPs proceeds at pH between 4.0 and 10.0. Under the optimized conditions, the electrocatalytic oxidation peak current of captopril showed two linear dynamic ranges with a detection limit of 8.28×10-2 µM captopril. The linear calibration range was 1.14-16.98 and 21.49-62.1 µM using amperometric. Finally, the sensor was examined as a selective, simple, and precise new electrochemical sensor for the determination of captopril in pharmaceutical samples including tablets and satisfactory results were obtained.

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