Lipid Lowering Effects of Aqueous Saffron Extract in Diabetic Rats
الموضوعات : Report of Health CareElham Adibfar 1 , Seyed Ali Hoseini 2 , Omidreza Salehi 3 , Fatemeh Farkhaie 4 , Parvin Shah Hosseini 5
1 - Department of Sport Physiology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
2 - Department of Sport Physiology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
3 - Department of Sport Physiology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
4 - Department of Sport Physiology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
5 - Doctor of Veterinary Medicine
الکلمات المفتاحية: Saffron, Diabetes, Lipid Profile,
ملخص المقالة :
Introduction: Diabetes mellitus is one of the most common non-communicable and chronic diseases. The present study aimed to review the lipid lowering effects of aqueous saffron extract in diabetic rats. Methods: Sixty diabetic rats with fasting blood glucose of over 300 mg/dl were selected as sample and divided in two groups of saffron extract and control. Group of saffron extract received 25 mg/kg daily aqueous saffron extract peritoneally for 4 weeks. Lipid profile was measured by enzymatic method with zist shimi commercial kits provided by yasa teb Company. For statistical analysis of data, Kalmogorov- Smirnov test and paired sample and independent sample t- tests (p≤0.05) were used. Results: Findings showed that 4 weeks saffron extract induces significant reduction in LDL, VLDL, TG and Cho of diabetic rats (p=0.001); nevertheless, it has no significant effect on HDL (p=0.07). Conclusion: It is concluded that 4 weeks aqueous saffron extract has lipid lowering effect in diabetic rats.
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