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عنوان URL للمقالة


رقم المقالة : JRHC-1808-1102 زيارة : 45 الصفحة: 67 - 80

نوع المخطوط: ابحاث

The Therapeutic Effects of Medicinal Plants on Depression and Anxiety Disorders

الموضوعات : Report of Health Care

Seyed Ebrahim Hosseini 1 , Seyed Ali Hosseini 2

1 - Department of Biology, Shiraz Branch, Islamic Azad University, Shiraz, Iran
2 - Department of Sport Physiology, Marvdasht Branch, Islamic Azad University, Marvdasht , Iran

تاريخ الإرسال : 23 الأحد , ذو القعدة, 1439 تاريخ التأكيد : 23 الأحد , ذو القعدة, 1439 تاريخ الإصدار : 13 الخميس , جمادى الثانية, 1439

الکلمات المفتاحية: Depression, anxiety, Medicinal Plants,

ملخص المقالة :

Anxiety and depression are among the commonly occurring illnesses around the world that cause changes in the lifestyle of humans and impose huge costs to treat these disorders on human societies. These disorders can be associated with physiological symptoms such as tachycardia, sweating, respiratory dysfunction, numbness, and sometimes paralysis of the limbs, etc. In the treatment of these diseases, the goal is to help people to minimize the risk of following side effects while healing these disorders. In the treatment of drugs in the past, benzodiazepine drugs such as diazepam (valium), alprazolam (xanax), lorazepam (ativan), and baspiron were used to treat anxiety disorders. However, presently anti-depressant drugs such as fluxetin, paroxetine, sertaline, and venlafaxine are more widely administered. It is estimated that between 10 to 20% of people in the western hemisphere use these drugs almost regularly . In depression studies, monoamine neurotransmitters such as serotonin (5- HT), neuroadrenaline (NA) and dopamine (DA) play an important role in mediating depressive behaviors. Various studies have shown that major depressive symptoms are caused by a reduction in the function of these neurotransmitters. Monoamine oxidase enzyme (MAOA) is also a key enzyme dependent on the metabolism of neurotransmitters, and it has been suggested that its activity is one of the indicators of psychosomatic susceptibility. It has also been observed that the hypothalamic-pituitary-adrenal axis (HPA) is impaired in patients with depression. The use of herbal medicine has been commonplace in ancient civilizations, and hence since ancient times plants have long been an important source of medicine. Research on plants in recent years has shown that plants such as chamomile and lavender, which have formerly been used to treat anxiety and depression have anti-anxiety and anti-depression effects; accordingly, in the present study, the effects of 18 plant types on the treatment of these disorders have been investigated.

المصادر:


  1. Shahinfar J, Zeraati H, Nasimi F, Shojaei S. Effect of medicinal plants on anxiety. JIITM. 2017; 8 (2): 209- 222.
    2.
  2. Rabie Z, Rabie S, Lorigoieni Z. A review on antidepressant effects medicinal plants with emphasis on their mechanisms of action. JMP. 2016; 4 (60):24- 38.
    3.
  3. Sylvers P, Lilienfeld SO, LaPrairie JL. Differences between trait fear and trait anxiety: Implications for psychopathology. Clin Psychol Rev. 2011; 31 (1): 122- 137.
    4.
  4. McHenry J, Carrier N, Hull E, Kabbaj M. Sex differences in anxiety and depression: role of testosterone. Frontiers Neur. 2014; 35 (1): 42- 57.
    5.
  5. Saki K, Bahmani M, Rafieian- Kopaei M. The effect of most important medicinal plants on two importnt psychiatric disorders (anxiety and depression)-a review. Asian Pacific J Tro Med. 2014; 7 (1): S34- S42.
    6.
  6. Solati J, Sanaguye Motlagh H. Anxiolytic effects of Valepotriates extracted from Valeriana officinalis L. in rats. J Qazvin Univ Med Sci. 2008; 12 (3): 63- 67.
    7.
  7. Fields AM, Richards TA, Felton JA, Felton SK, Bayer EZ, Ibrahim IN, et al. Analysis of responses to valerian root extract in the feline pulmonary vascular bed. J Altern Complement Med. 2003; 9 (6): 909-918.
    8.
  8. Chen CV, Brummet JL, Lonstein JS, Jordan CL, Breedlove SM. New knockout model confirms a role for androgen receptors in regulating anxiety- like behaviors and HPA response in mice. Hormones Behav. 2014; 65 (3): 211- 218.
    9.
  9. Akbarian Z, Kohan S, Nasiri H, Ehsanpour S. The effects of mental health training program on stress, anxiety, and depression during pregnancy. Iran J Nurs Midwifery Res. 2018; 23 (2): 93- 97.
    10.
  10. Pigott TA. Anxiety disorders in women. Psychiatric Clin North Am. 2003; 26 (3): 621- 672.
    11.
  11. de Graaf R, Bijl RV, Smit F, Vollebergh WA, Spijker J. Risk factors for 12-month comorbidity of mood, anxiety, and substance use disorders: Findings from the Netherlands Mental Health Survey and Incidence Study. Am J Psychiatry. 2002; 159 (4): 620- 629.
    12.
  12. Kuloglu M, Atmaca M, Tezcan E, Ustundag B, Bulut S. Antioxidant enzyme and malondialdehyde levels in patients with panic disorder. Neuropsychobiology J. 2002; 46 (4): 186- 189.
    13.
  13. Khanzode SD, Dakhale GN, Khanzode SS, Saoji A, Palasodkar R. Oxidative damage and major depression: the potential antioxidant action of selective serotonin re-uptake inhibitors. Redox Rep. 2003; 8 (6): 365- 370.
    14.
  14. Ng F, Berk M, DeanO, Bush AI. Oxidative stress in psychiatric disorders: evidence base and therapeutic implications. Int J Neuropsychopharmac. 2008; 11 (6): 851- 876.
    15.
  15. Hosseini SE, Hamzavi S, Agh baba H. The effects of alcoholic extract of Red poppy (Papaver rhoeas) on anxiety induced by elevated plus maze and the plasma corticosterone levels in adult male Wistar rats. J Sabzevar Univ Med Sci. 2015; 22 (4): 557- 564.
    16.
  16. Bouayed J, Rammal H, Soulimani R. Oxidative stress and anxiety: relationship and cellular pathways. Oxid Med Cell Longev. 2009; 2 (2): 63- 67.
    17.
  17. Hatano VY, Torricelli AS, Giassi AC, Coslope LA, Viana MB. Anxiolytic effects of repeated treatment with an essential oil from Lippia alba and (R)-(-)-carvone in the elevated T-maze. Braz J Med Biol Res. 2012; 45 (3): 238- 243.
    18.
  18. Dadfar F, Hosseini SE, Bahaoddini A. A review of phytochemical, pharmacological and physiological properties of ginger (zingiber officinale). Clin Exc. 2014; 3 (1): 72- 86.
    19.
  19. Nikfarjam M, Parvin N, Asarzadegan N. The effect of Lavandula angustifolia in the treatment of mild to moderate depression. J Shahrekord Univ Med Sci. 2010; 11 (4): 66- 73.
    20.
  20. Sahraei H, Fatemi SM, Monzavy Z, Shams J, Pashaei Rad S. Effect of plant extracts (Papaver rhoeas L) shaghayegh on the acquisition and expression of morphine-induced conditioned place preference in male mice. JMP. 2006; 5 (19): 65- 75.
    21.
  21. Osanloo N, Najafi-Abedi A, Jafari F, Javid F, Pirpiran M, Memar Jafari MR, et al. Papaver Rhoeas L. hydroalcoholic extract exacerbates forced swimming test- induced depression in mice. Basic Clin Neurosci. 2016; 7 (3): 195- 202.
    22.
  22. Tsigos C, Chrousos GP. Hypothalamic- pituitary- adrenal axis, neuroendocrine factors and stress. J Psychosom Res. 2002; 53 (4): 865- 871.
    23.
  23. Lee G, Bae H. Therapeutic effects of phytochemicals and medicinal herbs on depression. Biomed Res Int. 2017; 2017: 6596241.
    24.
  24. Heidari MR, Mandegary A, Hosseini A, Vahedian M. Anticonvulsant effect of methanolic extract of echium amoenum fisch and C.A. mey. against seizure induced by picrotoxin in mice. Biol Sci. 2006; 9 (4): 772- 776.
    25.
  25. Ranjbar A, Khorami S, Safarabadi M, Shahmoradi A, Malekirad AA, Vakilian K, et al. Antioxidant activity of Iranian Echium amoenum Fisch and C.A. Mey flower decoction in humans: A cross-sectional before/ after clinical trial. Evid Based Complement Alternat Med. 2006; 3 (4): 469- 473.
    26.
  26. Min J, Yu SW, Baek SH, Nair KM, Bae ON, Bhatt A, et al. Neuroprotective effect of cyanidin-3-O-glucoside anthocyanin in mice with focal cerebral ischemia. Neurosci Lett. 2011; 500 (3): 157- 161.
    27.
  27. Hwang MK, Kang NJ, Heo YS, Lee KW, Lee HJ. Fyn kinase is a direct molecular target of delphinidin for the inhibition of cyclooxygenase-2 expression induced by tumor necrosis factor-alpha. Biochem Pharmacol. 2009; 77 (7): 1213- 1222.
    28.
  28. Abolhassani M. Antibacterial effect of borage (Echium amoenum) on staphylococcus aureus. Braz J Infect Dis. 2004; 8 (5): 382- 385.
    29.
  29. Heidari MR, Azad EM, Mehrabani M. Evaluation of the analgesic effect of Echium amoenum Fisch and C.A. Mey. extract in mice: possible mechanism involved. J Ethnopharmacol. 2006; 103 (3): 345- 349.
    30.
  30. Rabbani M, Sajjadi SE, Vaseghi G, Jafarian A. Anxiolytic effects of Echium amoenum on the elevated plus-maze model of anxiety in mice. Fitoterapia J. 2004; 75 (5): 457- 464.
    31.
  31. Batool F. Buspirone and anxiety disorders: a review with pharmacological and clinical perspectives. Int J Pharm. 2007; 5 (2): 1- 6.
    32.
  32. Blanco MM, Costa CA, Freire AO, Santos JJ, Costa M. Neurobehavioral effect of essential oil of cymbopogon citratus in mice. Phyto Med. 2009; 16 (2- 3): 265- 270.
    33.
  33. Amirghofran Z, Azadbakht M, Keshavarzi F. Echium amoenum stimulate of lymphocyte proliferation and inhibit of humoral antibody synthesis. Iran J Basic Med Sci. 2000; 25 (3- 4): 119- 124.
    34.
  34. Javid Z, Hosseini SE. Comparison of the effect of echium amoenum with buspironeon the anxiety of maze in adult male rats. Horizon Med Sci J. 2016; 22 (1): 51- 56.
    35.
  35. Sayyah M, Boostani H, Pakseresht S, Malaieri A. Efficacy of aqueous extract of Echium amoenum in treatment of obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2009; 33 (8): 1513- 1516.
    36.
  36. Honari N, Pourabolli I, Hakimi zadeh E, Shamsizadeh A, Amin F, Allatavakoli M. Effect of vitex agnus- castus extract on learning and memory in ovariectomized rats. J Mazandaran Univ Med Sci. 2012; 22 (93): 2- 10.
    37.
  37. Namvaran- Abbas- Abad A, Khayat- Nouri M. Interactions between matricaria recutita and cisplatin on PTZ- induced seizure threshold in mice. Feyz Med Sci Univ J. 2011; 15 (3): 188- 193.
    38.
  38. Sayyah M, Sayyah M, Kamalinejad M. A preliminary randomized double blind clinical trial on the efficacy of aqueous extract of Echium amoenum in the treatment of mild to moderate major depression. Prog Neuropsychopharmacol Biol Psychiatry. 2006; 30 (1): 166- 169.
    39.
  39. Rabiei Z, Moghtadaei M, Mokhtari S, Rafieian- Kopaei M. Atricaria chamomilla essential oil with physical training improves passive avoidance memory of wistar rats. Ir J Physiol Pharmacol. 2016; 2 (2): 96- 104.
    40.
  40. Brown E, Hurd NS, McCall S, Ceremuga TE. Evaluation of the anxiolytic effects of chrysin, a Passiflora incarnate extract, in the laboratory rat. AANA J. 2007; 75 (5): 333- 337.
    41.
  41. Keefe JR, Mao JJ, Soeller I, Li QS, Amsterdam JD. Short-term open-label Chamomile (Matricaria chamomilla L.) therapy of moderate to severe generalized anxiety disorder. Phytomedicine. 2016; 23 (14): 1699- 1705.
    42.
  42. Heidari MR, Dadollahi Z, Mehrabani M, Mehrabi H, Pourzadeh- Hosseini M, Behravan E. Study of antiseizure effects of Matricaria recutita extract in mice. Ann NY Acad Sci. 2009; 1171: 300- 304.
    43.
  43. Dhawan K, Kumar S, Sharma A. Comparative biological activity study on passiflora incarnata and P. edulis. Fitoterapia J. 2001; 72 (6): 698- 6702.
    44.
  44. Dhawan K, Dhawan S, Sharma A. Passiflora: a review update. J Ethnopharmacol. 2004; 94 (1): 1- 23.
    45.
  45. Dehghan M, Abdoli Tafti A, Razi S, Amiri M. Efficacy of passiflora incarnate on anxiety relief before orthopedic surgery: a double blinded clinical trial study. J Shahrekord Univ Med Sci. 2016; 18 (3): 68- 77.
    46.
  46. Kim M, Lim H-S, Lee H-H, Kim T-H. Role identification of passiflora incarnata linnaeus: a mini review. J Menopausal Med. 2017; 23 (3): 156- 159.
    47.
  47. Roozbehi A, Delaviz H, Heidarian A, Mohamadi J. The effect of hydroalcohlic extract of Valeriana officinalis on the astrocytes of hippocampus in rats. Yasouj Med Sci Unic J. 2015; 20 (4): 298- 308.
    48.
  48. Rezvani ME, Roohbakhsh A, Allahtavakoli M, Shamsizadeh A. Anticonvulsant effect of aqueous extract of valeriana officinalis in amygdala-kindled rats: possible involvement of adenosine. J Ethnopharmacol. 2010; 127 (2): 313- 318.
    49.
  49. Carrettiero DC, Da Silva SM, Fior-Chadi DR. Adenosine modulates alpha2-adrenergic receptors through a phospholipase C pathway in brainstem cell culture of rats. Auton Neurosci. 2009; 151 (2): 174- 177.
    50.
  50. Dietz BM, Mahady GB, Pauli GF, Farnsworth NR. Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro. Brain Res Mol Brain Res. 2005; 138 (2): 191- 197.
    51.
  51. Asishirazi E, Hosseini SA, Keikhosravi F. The hypoglycemic interactional effect of saffron aqua extract and swimming training in streptozotocin induced diabetic rats. J Sabzevar Med Sci Univ. 2017; 24 (4): 273- 279.
    52.
  52. Babaei A, Arshami J, Haghparast AR, Danesh Mesgaran M. Effects of crocus sativus petals extract on blood parameters in rat. J Arak Uni Med Sci. 2013; 16 (6): 14- 21.
    53.
  53. Emamghoreishi M, Ghasemi F. The effect of subchronic administration of the aqueous and hydro- alcoholic extracts of crocus sativus from estahbanat, fars province, on mice. Yasouj Med Sci Univ J. 2012; 16 (6): 527- 536.
    54.
  54. Noorbala AA, Akhondzadeh Sh, Tahmacebi -Pour N, Jamshidi AH. Hydro - alcoholic extract of Crocus sativus L. versus fluxetine in the treatment of mild to moderate depression: a double - blind, randomized pilot trial. J Ethnopharmacol. 2005; 97: 281- 284.
    55.
  55. Bangratz M, Ait Abdellah S, Berlin A, et al. A preliminary assessment of a combination of rhodiola and saffron in the management of mild–moderate depression. Neuropsychiatr Dis Treat. 2018; 14: 1821- 1829.
    56.
  56. Moazen- Zadeh E, Abbasi SH, Safi- Aghdam H, Shahmansouri N, Arjmandi- Beglar A, Hajhosseinn Talasaz A. Effects of saffron on cognition, anxiety, and depression in patients undergoing coronary artery bypass grafting: a randomized double- blind placebo- controlled trial. J Altern Complement Med. 2018; 24 (4): 361- 368.
    57.
  57. Lopresti AL, Drummond PD, Inarejos- García AM, Prodanov M. Saffron, a standardised extract from saffron (Crocus sativus L.) for the treatment of youth anxiety and depressive symptoms: a randomized, double- blind, placebo- controlled study. J Affect Disord. 2018; 232: 349- 357.
    58.
  58. Ahmad AS, Ansari MA, Saleem S, Yousuf S, Hoda MN, Islam F. Neuroprotection by crocetin in a hemi- parkinsonian rat model. Pharm Biochem Behav. 2005; 81(4): 805- 813.
    59.
  59. Akhondzadeh Sh, Kashani L, Fotouhi A, Jarvandi S, Mobasheri M. Comparison of lavandula angastifolia mill tincture and imipramine in the treatment of mild to moderate depression, a double -blind randomized trial. Prog Neuropsychopharmacol Biol Psychiat. 2003; 27: 7-123.
    60.
  60. Cavanagh HM, Wilkinsin JM. Biological activities of lavender essential oil. Phytother Res. 2002; 16: 301- 308.
    61.
  61. Mehrabani M, Modirian E, Ebrahimabadi AR. Study of the effects of hydromethanol extracts of lavandula vera DC. and cuscuta epithymum murr. on the seizure induced by pentylentetranzol in mice. J Kerman Med Sci Univ. 2007; 14: 25- 32.
    62.
  62. Rezaei A, Jafari B, Jalilzadeh HM. Study of sedative, preanaesthetic and anxiolytic effect of herbal extract of lavandula stoechas in comparison with diazepam. J Tabriz Med Sci Univ. 2010; 3: 899- 905.
    63.
  63. Hosseini SE, Keramaty F, Safavy Naeiny Kh. A comparative study of massage with lavender (Lavandula) essential oil and almond oil on pain relief after cesarean operation in primiparous women. J Tabriz Med Sci Univ. 2016; 38 (2): 22- 27.
    64.
  64. Cui B, Wu M, She X. Effects of chronic noise exposure on spatial learning and memory of rats in relation to neurotransmitters and NMDAR2B alteration in the hippocampus. J Occup Health. 2009; 51 (2): 152- 158.
    65.
  65. Mohammadkhani Shahri L, Abbaspoor Z, Aghel N, Mohammadkhani Shahri H. Effect of massage aromatherapy with lavender oil on pain intensity of active phase of labor in nulliparous women. JMP. 2012; 2 (9): 167- 176.
    66.
  66. Abbasi Maleki S, Bekhradi R, Asgharpanah J, Abbasi Maleki F, Maleki Ahanghari N. Antidepressant- like effect of aqueous and hydroalcoholic extracts of lavandula angustifolia mill in forced swim test and tail suspension test in male mice. J Arak Med Sci Univ. 2013; 16 (9): 65- 75.
    67.
  67. Fanoudi S, Alavi MS, Karimi G, Hosseinzadeh H. Milk thistle (Silybum Marianum) as an antidote or a protective agent against natural or chemical toxicities: a review. Drug Chem Toxicol. 2018; 22: 1- 15.
    68.
  68. Hadinia A, Aryanpour R, Mehdizadeh M, Mahmodi R, Mossavizadeh A, Delaviz H, et al . The effect of silybum marianum on GFAP and spatial memory in a mouse model of alzheimer's disease. J Yasouj Med Sci Univ. 2010; 14 (4): 65- 75.
    69.
  69. Karimi G, Saradeghi Keisari M. Evaluation of antidepressant effect of ethanolic and aqueous extracts of silybum marianum L. seed in mice. JMP. 2007; 4 (24): 38- 43.
    70.
  70. Li YJ, Li YJ, Yang LD, Zhang K, Zheng KY, Wei XM, et al. Silibinin exerts antidepressant effects by improving neurogenesis through BDNF/TrkB pathway. Behav Brain Res. 2018; 348: 184- 191.
    71.
  71. Ayoughi F, Marzegar M, Sahari M, Naghdibadi H. Chemical compositions of essential oils of Artemisia dracunculus L. and endemic Matricaria chamomilla L. and an evaluation of their antioxidative effects. J Agri Sci Technol. 2010; 13: 79- 88.
    72.
  72. Sengul M, Ercisli S, Yildiz H, Gungor N, Kavaz A, Çetin B. Antioxidant, antimicrobial activity and total phenolic content within the aerial parts of artemisia absinthum, artemisia santonicum and saponaria officinalis. Iran J Pharma Res. 2011; 10 (1): 49- 56.
    73.
  73. Wang J, Fernández AE, Tiano S, Huang J, Floyd E, Poulev A, et al. An Extract of artemisia dracunculus L. promotes psychological resilience in a mouse model of depression. Oxid Med Cell Longev. 2018; 2018: 7418681.
    74.
  74. Khosravi H, Rahnema M, Asle-Rousta M. Anxiolytic and antidepressant effects of tarragon (Artemisia dracunculus L.) hydroalcoholic extract in male rats exposed to chronic restraint stress. Nova Biol Rep. 2017; 4: 1- 8.
    75.
  75. Karimi A, Nazem F, Sazvar A. Effects of aerobic training, extract of althaea kurdica and noise stress on the anxiety- related behaviors, plasma levels of nitric oxide and serotonin in wistar male rats. J Isfahan Med Sch. 2016; 33 (357): 1843- 1850.
    76.
  76. Duman RS. Neural plasticity: consequences of stress and actions of antidepressant treatment. Dialogues Clin Neurosci. 2004; 6 (2): 157- 169.
    77.
  77. Sarkaki A, Rfieirad M, Hosseini SE, Farbood Y, Motamedi F, Mansouri SM, et al. Improvement in memory and brain long- term potentiation deficits due to permanent hypoperfusion/ischemia by grape seed extract in rats. Iran J Basic Med Sci. 2013; 16 (9): 1004- 1010.
    78.
  78. Rabiee Z, Davoodizadeh Z, Bijad E, Rafieian-kopaei M. Evaluation of the effects of grape seed oil on the anxiety level and motor coordination of male wistar rats. JBUMS. 2016; 18 (6): 52- 58.
    79.
  79. Hovatta I, Tennant RS, Helton R, Marr RA, Singer O, Redwine JM, et al. Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice. Nature. 2005; 438 (7068): 662- 666.
    80.
  80. Rabiei Z, Rafieian- kopaei M, Heidarian E, Saghaei E, Mokhtari S. Effects of zizyphus jujube extract on memory and learning impairment induced by bilateral electric lesions of the nucleus basalis of meynert in rat. Neuroche Res. 2014; 39 (2): 353- 360.
    81.
  81. Hosseini SE, Avazpour Y. Effect of hydro- ethanolic extract of currant on amount of anxiety in adult male mice in plus maze model. J Animal Physiol Develop. 2016; 9 (2): 57- 62.
    82.
  82. Zar A, Hoseini‎ A, Ahmadi F, Rezaei M. Effects of ginger together with swimming training on blood fat profiles in adult diabetic rats with streptozotocin. Iranian J Nutr Sci Food Technol. 2016; 11 (2): 65- 74.
    83.
  83. Hosseini SA, Nemati J, Ranjbar M, Edalatmanesh M, Zar A. Hypoglycemic interactive effects of ginger extract and endurance training in diabetic rats. Horizon Med Sci. 2017; 23 (4): 325- 330.
    84.
  84. Dadfar F, Hosseini SE, Bahaoddini A. A review of phytochemical, pharmacological and physiological properties of ginger (zingiber officinale). Clin Exc. 2014; 3 (1): 72- 86.
    85.
  85. Farzin D, Fathiazad F, Fazellian M. Antidepressant effect of methanolic ginger extract in diabetic mice using forced- swim test. J Mazandaran Univ Med Sci. 2013; 23 (98): 208- 220.
    86.
  86. Karami M, Hossini SE, Shahbi Majd N, Ebrahimzadeh MA, Alemy S. Salvia limbata: botanical, chemical, pharmacological and therapeutic effect. Clin Exc. 2015; 3 (2): 1- 14.
    87.
  87. Piri M, Nasehi M, Mafi F, Shahin M, Zarrindast M. Interaction between nicotine and dopaminergic D1 receptor of dorsal hippocampus in the hole-board test of anxiety. J Qazvin Univ Med Sci. 2012; 16 (2): 44- 51.
    88.
  88. Hosseinzadeh H, Karimi GR, Rakhshanizadeh M. Anticonvulsant effects of aqueous and ethanolic extracts of hypericum perforatum L in mice. JMP. 2004; 3 (10): 4- 6.
    89.
  89. Sabzkhah S, Vaezi Gh, Bakhtiarian A, Salarian A, Zare Haghighi M. The effect of D2 agonist versus D2 antagonist on the fear behavior in the male rats using plus- maze method: the prospective study. Tehran Univ Med Sci J. 2009; 67 (8): 535- 541.
    90.
  90. Holmes A, Parmigiani S, Ferrari PF, Palanza P. Rodgers RJ. Behavioral profile of wild mice in the elevated plus maze test for anxiety. Physiol Behav. 2000; 71 (5): 509- 516.
    91.
  91. Philipp M. Hypericum extract versus imipramine or olacebo in patient with moderate depression:randomizedmulticentre study of treatment for eight weeks. BMJ. 2007; (319): 1534- 1539.
    92.
  92. Erfani N, Shahsavari A. The effect of hypiran on anxiety among students in karaj university's dormitories. Mendish J. 2012; 3 (4-5):76- 84.
    93.
  93. Hoseini SA, Zar A, Javedan F, Edalatmanesh MA. Effect of 15 days cinnamon supplementation on hematocrit and blood pressure response in one session aerobic exercise. CMJA. 2016; 6 (3): 1571- 1582.
    94.
  94. Suhaj M. Spice antioxidants isolation and their antiradical activity: a review. J Food Compos Anal. 2006; 19: 531- 537.
    95.
  95. Fadaei S, Asle-Rousta M. Anxiolytic and antidepressant effects of cinnamon (Cinnamomum verum) extract in rats receiving lead acetate. J Kurdistan Univ Med Sci. 2018; 22 (6): 31- 39.
    96.
  96. Kamaliroosta L, Ghavami M, Gharachorloo M, Azizinezhad R. Isolation of cinnamon extract and assessing its effect on the stability of sunflower oil. Iranian J Nutr Sci Food Technol. 2011; 6 (1): 13- 22.
    97.
  97. Javanmardi J, Khalighi A, Kashi A, Bais HP, Vivanco JM. Chemical characterization of basil (Ocimumbasilicum L.) found in local accessions and used in traditional medicines in Iran. J Agricult Food Chem. 2002; 50 (21): 5878- 5883.
    98.
  98. Ghasemzadeh A, Ashkani S, Baghdadi A, Pazoki A, Jaafar HZ, Rahmat A. Improvement in flavonoids and phenolic acids production and pharmaceutical quality of sweet basil (Ocimum basilicum L.) by ultraviolet- B irradiation. Molecules J. 2016; 21 (9): E1203.
    99.
  99. Jin X, Liu P, Yang F, Zhang YH, Miao D. Rosmarinic acid ameliorates depressive-like behaviors in a rat model of CUS and up-regulates BDNF levels in the hippocampus and hippocampal-derived astrocytes. Neurochemicol Res. 2013; 38 (9): 1828- 1837.
    100.

100. Sloley BD, Urichuk LJ, Morley P, Durkin J, Shan JJ, Pang PK, et al. Identification of kaempferol as a monoamine oxidase inhibitor and potential neuroprotectant in extracts of Ginkgo biloba leaves. J PharmPharmacol. 2000; 52 (4): 451- 459.

101. Tewari D, Pandey HK, Sah AN, Meena H, Chander V, Singh R, et al. Phytochemical, antioxidant and antidepressant evaluation of ocimum basilicum, O. tenuiflorum, O. kilimandscharicum grown in india. JBAPN. 2015; 5 (2): 120- 131.

102. Mostafapour P, Asle-Rousta M, Rahnema M. Anxiolytic and antidepressant effects of basil (Ocimum basilicum L.) hydro-alcoholic extract in male rats exposed to chronic restraint stress. JSSU. 2018; 25 (11): 887- 896.

103. Jedi-Behnia B, Abbasi Maleki S, Mousavi E. The antidepressant-like effect of mentha spicata essential oil in animal models of depression in male mice. J Fasa Univ Med Sci. 2017; 7 (1): 141- 149.

104. Karimi A, Nazem F, Sazvar A. Effects of aerobic training, extract of althaea kurdica flower and noise stress on the anxiety-related behaviors of wistar male rat. RJMS. 2015; 22 (135): 1- 8.

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