پیش‌تغلیظ مقادیر ناچیز کلونازپام در نمونه‌های آبی با نانولوله‌های‌کربنی کربوکسیل‌دارشده
الموضوعات :نرگس صالحی 1 , علی مقیمی 2 , میلاد ابنیکی 3
1 - دانش‌آموخته مقطع دکترا گروه شیمی، دانشکده شیمی دارویی، دانشگاه علوم پزشکی آزاد اسلامی تهران، تهران، ایران.
2 - دانشیار گروه شیمی، دانشکده شیمی دارویی، دانشگاه علوم پزشکی آزاد اسلامی تهران، تهران، ایران.
3 - دانش‌آموخته مقطع دکترا گروه پژوهشی رزین و افزودنی‌ها، پژوهشگاه علوم و فناوری رنگ، تهران، ایران.
الکلمات المفتاحية: نانولوله¬های کربنی کربوکسیل‌دارشده, طیفنور¬سنجی مرئی و فرابنفش, داروی کلونازپام.,
ملخص المقالة :
در این پژوهش، با روش جديد استخراج فاز جامد پخشی مقدارهای ناچیز پساب‌های دارویی بهعنوان شاخص داروی کلونازپام در نمونه‌های آبی با نانولوله‌های کربنی کربوکسیل‌دارشده ارائه و اندازه‌گیری مقدار دارو با طیفسنجی مرئی و فرابنفش در نمونه‌های حقیقی انجام شد. نانولوله‌های کربوکسیل‌دارشده با طیفسنجی فروسرخ تبدیل فوریه (FTIR)، پراش پرتو ایکس (XRD) و میکروسکوپ الکترونی روبشی (SEM) شناسایی شدند. در اين روش، يك سامانه دو فازي به‌کارگرفته شد كه در آن فاز دهنده نمونه‌هاي آبي حاوي کلونازپام و فاز گيرنده نانولوله‌هاي‌كربني کربوکسیل‌دارشده بودند. آزمايشها در دو مرحله استخراج از نمونه‌هاي آبي و واجذب داروی کلونازپام با حلال آمونیاک انجام و نمونه‌هاي واجذب‌شده براي تجزیه بيشتر با دستگاه طیفسنجی مرئی و فرابنفش بررسی شدند. اين روش ارزان، ساده و سريع است. همچنین، روشی حساس و مطمئن براي استخراج و پيشتغليظ و اندازهگيري مقادیر ناچیز کلونازپام به‌حساب می‌آید. عامل‌های مؤثر بر استخراج مانند pH، مقدار و نوع حلال شوینده و زمان استخراج بررسی شدند. فاکتور تغلیظ، مقدار حد تشخیص روش (LOD) و انحراف استاندارد نسبی به ترتیب برابر با 30، 1- mg.l2/1 و 4/2 درصد بهدست آمدند.
[1] Ståhl Y, Persson A, Petters I, Rane A, Theorell K, Walson P. Kinetics of clonazepam in relation to electroencephalographic and clinical effects. Epilepsia. 1983;24(2):225–231. doi: 10.1111/j.1528-1157.1983.tb04883.x
[2] Moghimi A, Abniki M, Qomi M. Removal of lead (II) using modified octadecyl silica nanomagnetic disks with dioctyl phthalate by atomic absorption spectroscopy. Journal of Quantum Chemistry and Spectroscopy [persian]. 2020;10(33):42–48.
[3] Moghimi A, Abniki M, Yari M. Effective removal of mercury (II) from environmental aqueous samples using carbon nanotubes carboxylated by dispersive solidphase extraction method. Journal of Environmental Geology. 2020;52:15–22.
[4] Moghimi A, Abniki M. Dispersive solid-phase extraction for preconcentration of colored effluent in aqueous samples using magnetic carbon nanotubes modified with chitosan. Journal of Quantum Chemistry and Spectroscopy. 2020;9(32):60–68.
[5] Cooper G. Therapeutic uses of botulinum toxin. Totowa: Humana Press; 2007.
[6] Abniki M, Moghimi A. Synthesis of chitosan functionalized magnetic carbon nanotubes for dispersive solid‐phase extraction of bromocresol green. Micro & Nano Letters. 2021;16:455-62. doi: 10.1049/mna2.12067
[7] Moghimi A, Qomi M, Yari M, Abniki M. Solid phase extraction of Hg (П) in water samples by nano-Fe3O4 encapsulated-dioctylphthalate and linked-diethylenetriamine. Int J Bio-Inorg Hybr Nanomater. 2019;8(4):159-168.
[8] Moghimi A, Abniki M. Removal and measurement of bromocresol purple dye in aqueous samples by β-cyclodextrin-modified magnetic carbon nanotube with dispersive solid-phase extraction technique. Journal of Color Science and Technology. 2022;15:301-315. doi: 20.1001.1.17358779.1400.15.4.4.5
[9] Abniki M, Moghimi A, Azizinejad F. Synthesis of calcium‐layered double hydroxide based nanohybrid for controlled release of an anti‐inflammatory drug. Chinese Chemical Society Taipei. 2020;68:343-52. doi: 10.1002/jccs.202000008
[10] Moghimi A, Abniki M. The dispersive solid-phase extraction of fluoxetine drug from biological samples by the amine-functionalized carbon nanotubes with HPLC method. Chemical Methodologies. 2021;5:250-8. doi: 10.22034/chemm.2021.128586
[11] Abniki M, Azizi Z, Poorebrahim S, Moniri E. Development of p-amino acetanilide functionalized multi-walled carbon nanotubes as an effective carrier for lansoprazole release. Biomedical physics & engineering express. 2023;9(4):37167956. doi: 10.1088/2057-1976/acd459
[12] Abniki M, Moghimi A, Azizinejad F. Fabrication of bionanocomposite based on LDH using biopolymer of gum arabic and chitosan-coating for sustained drug-release. Journal of the Serbian Chemical Society. 2020;85:1223-35. doi: 10.2298/JSC191011004A
[13] Parsayi Arvand M, Moghimi A, Abniki M. Extraction of alprazolam in biological samples using the dispersive solid‐phase method with nanographene oxide grafted with Α‐pyridylamine. IET Nanobiotechnology. 2023;17:69-79. doi: 10.1049/nbt2.12105
[14] Moghimi A, Abniki M. dispersive solid-phase extraction for bromocresol green removal with β-cyclodextrin functionalized magnetic nanotubes. Russian Journal of Physical Chemistry B. 2021;15:S130-S9. doi: 10.1134/S1990793121090128
[15] Moghimi A, Abniki M. Preconcentration and separation of ultra-trace Cu(II) with disks of octadecyl silica membrane modified nano-Fe3O4-encapsulated-dioctyl phthalate and linked-diethylenetriamine. Advanced Journal of Chemistry-Section A. 2021;4:78-86. doi: 10.22034/ajca.2021.260252.1230
[16] Moghimi A, Abniki M, Khalaj M, Qomi M. Construction of modified nanotube carbon carboxyl by new method and application in dispersive solid phase extraction for preconcentration of Ni2+. Revue Roumaine de Chimie. 2021;66(6):493-507. doi: 10.33224/rrch.2021.66.6.02
[17] Shojaei M, Moghimi A, Abniki M. Dispersive solid-phase extraction for preconcentration of Amlodipine in aqueous samples using Fe3O4@MWCNT- β cyclodextrin compositeand determinated. Quantum Chemistry and Spectroscopy. 2021;11(35):43-55.
[18] Moghimi, A. Preconcentration of Zn(II) from sample water by phenyl-iminodiacetic acid grafted multiwalled carbon nanotubes. Journal of Chemical Health Risks. 2012;2(3):28-41. doi: 10.22034/JCHR.2018.544002
[19] Abniki M, Moghimi A. Removal of Cd(II) ions from water solutions using dispersive solid-phase extraction method with 2-aminopyridine/graphene oxide nanoplates. Current Analytical Chemistry. 2022;18:1070-1085. doi: 10.2174/1573411018666220505000009
[20] Moghimi A, Poursharifi MJ. Perconcentration of trace Cr(III) using octadecyl silica membrane modified N, N-disalicylideneethylenediamine. Asian Journal of Chemistry, 2011;23(9):3870-3874.
[21] Tajodini N, Moghimi A. Spectrophotometric study of W(VI)-G lycinamide complex formation. Asian Journal of Chemistry. 2011;23(9):4186.
[22] Behrouzinia S, Zand M, Namdar A, Rahimi H, Moghimi A. The effect of operational parameters on the output power of copper vapor laser with small-bore tube. International Journal of Fundamental Physical Sciences. 2011;1 (3):67-72. doi: 10.14331/ijfps.2011.330015
[23] Karimnezhad K, Moghimi A, Adnan R, and Abniki M. An alternative method of dispersive solid‐phase extracting Hg (II) from environmental aqueous solutions using carboxylic functionalized carbon nanotubes. Micro & Nano Letters. 2022;18:e12150. doi: 10.1049/mna2.12150
[24] Ghammamy S, Khorsandtabar S, Moghimi A, Sahebalzamani H. Oxidation of some organic diols with trialkylammonium fluorochromates(VI), R3NH[CrO3F] (R= CH3, C2H5, C3H7 and C4H9) at room temperature and under microwave condition. Journal of the Mexican Chemical Society. 2009;53(2):41-43. doi: 10.29356/jmcs.v53i2.1003
[25] Moghimi A. Solid Phase Extraction of Cr(III) from natural water by modified nanopolyacrylonitrile fiber. World Applied Sciences Journal. 2011;12(12):2252-2259.
[26] Makipour P, Moghimi A, Ghiasi R. Preconcentration and spectrophotometric determination of copper (II) using octadecyl silica membrane disks modified by 1-nitroso-2-naphthol-3,6-disulfonic acid. Oriental Journal of Chemistry. 2010;26(3):797.
[27] Moghimi A. Preconcentration ultra trace of Cd(II) in water samples using dispersive liquid-liquid microextraction with salen(N,N′-Bis(salicylidene)-ethylenediamine) and determination graphite furnace atomic absorption spectrometry. Journal of the Chinese Chemical Society. 2008;55(2):369-376. doi: 10.1002/jccs.200800054
[28] Abniki M, Moghimi A. Nanomagnetic chitosan/β-cyclodextrin for dispersive solid phase extraction of trace desipramine drug. Materials Chemistry and Physics, 2024;316:129117.
doi: 10.1016/j.matchemphys.2024.129117
[29] Dahaji RRM, Moghimi A, Shahbazi H, Faraji H, Aziznejad F. Preparation of modified multiwalled carbon nanotubes (l-Arg-CS/MWCNTs-COOH/Fe3O4) as sorbent for dispersive solid phase extraction of Cu(II), Pb(II) and Cd(II) in wastewater samples. Revue Roumaine de Chimie. 2023;68(10–12):495–505. doi: 10.33224/rrch.2023.68.10-12.01
[30] Moghimi A. Separation and extraction of Co(II) using magnetic chitosan nanoparticles grafted with β-cyclodextrin and determination by FAAS. Russian Journal of Physical Chemistry A. 2014;88:2157–2164. doi: org/10.1134/S0036024414120024
[31] Moghimi A, Yousefi Siahkalrodi S. Extraction and determination of Pb(II) by organic functionalisation of graphenes adsorbed on surfactant coated C18 in environmental sample. Journal of Chemical Health Risks. 2013;3(3):1-12. doi: 10.22034/jchr.2018.544032
[32] Moghimi A, Abdouss M. Extraction of Co(II) by isocyanate treated graphite oxides (iGOs) adsorbed on surfactant coated C18 before determination by FAAS. International Journal of Bio-Inorganic Hybrid Nanomaterials. 2013;2(1):319-327.
[33] Salehi N, Moghimi A, Shahbazi H. Magnetic nanobiosorbent (MG-Chi/Fe3O4) for dispersive solid-phase extraction of Cu(II), Pb(II), and Cd(II) followed by flame atomic absorption spectrometry determination. IET. Nanobiotechnology. 2021;15:575-584. doi: 10.1049/nbt2.12025
[34] Salehi N, Moghimi A, Shahbazi H. Preparation of cross-linked magnetic chitosan with methionine-glutaraldehyde for removal of heavy metals from aqueous solutions. International Journal of Environmental Analytical Chemistry. 2022;102:2305-2321. doi: 10.1080/03067319.2020.1753718
[35] Salehi N, Moghimi A. Synthesis and identification of magnetic nickel oxide nanoparticles for the magnetic solid phase extraction of gemfibrozil and its determination by UV-Vis spectrometer. Applied Chemistry Today. 2022;102:2305-2321. doi: 10.22075/CHEM.2023.29235.2127
[36] Mahdavi Ghajari S, Allah Gholi Ghasri MR, Sedaghat S, Adhami F, Habibi S. Green synthesis of silver nanoparticles mediated using Mentha spicata leaf extract and electrospun silver/polyamide 6 nanofibers preparation for removal of copper ions from aqueous medium and isotherm and kinetics adsorption study. Journal of applied research in chemisry. 2024;2(17):59-74. doi: 10.30495/JACR.2022.1968287.2060.
[37] Nie P, Min C, Song H-J, Chen X, Zhang Z, Zhao K. Preparation and tribological properties of polyimide/carboxyl-functionalized multi-walled carbon nanotube nanocomposite films under seawater lubrication. Tribology Letters. 2015;58(1):7. doi: 10.1007/s11249-015-0476-7
[38] Mirzaei N, Rezaei V, Aibaghi B. Preconcentration and determination of diazepam in pharmaceutical and biological samples by graphene oxide based on dispersive solid phase microextraction. Applied Chemistry Today. 2019;14:21-32. doi: 10.22075/CHEM.2018.13851.1343.
[39] Alizadeh R, Salami M, Seidi S. A silica fiber coated with a ZnO-graphene oxide nanocomposite with high specific surface for use in solid phase microextraction of the antiepileptic drugs diazepam and oxazepam. Microchimica Acta. 2018;185(6):312. doi: 10.1007/s00604-018-2850-2
نشریه پژوهش‌های کاربردی در شیمی
(علمی – پژوهشی)
سال نوزدهم، شماره 2، پیاپی 74، تابستان 1404
مقالات در دست صفحه آرایی می‌باشند
