Effects of 8-weeks cinnamon intake with and without high intensity interval training on blood lipids profile in overweight girls of aged-high school
الموضوعات : Exercise Physiology and PerformanceSaber Rezanejad 1 , Mina Tarahhomi 2 , Akram khani Rozveh 3 , Mehdi Kargarfard 4
1 - Esfahan.Sepahanshar
2 - esfahan
3 - Department of Exercise Physiology, Faculty of Sport Sciences, University of Isfahan, Isfahan, Iran.
4 - Department of Exercise Physiology, Faculty of Sport Sciences, University of Isfahan, Isfahan, Iran
الکلمات المفتاحية: overweight, Cholesterol, Triglycerides, Cinnamon, High-Density Lipoprotein, Low-Density Lipoprotein, Intense Exercise,
ملخص المقالة :
Background: Obesity and overweight are among the most common complications among high school students, which can be associated with cardiovascular diseases. Modifying the lifestyle through sports activities and herbal medicines is one of the solutions to combat this problem. The purpose of this study was to evaluate the effect of an 8-week cinnamon consumption with and without high-intensity interval training on blood lipid profiles in high school-aged overweight girls.Methods: In this semi-experimental study with a pre-test and post-test design, 36 overweight women aged 15-18 years were randomly assigned to one of the 3 groups: intense interval training (n=12), cinnamon supplementation (n=12) and intense interval training+cinnamon (n=12). The intense interval training program was conducted three times a week for 8 weeks in the two intervention groups. Each session, lasting 30-35 minutes, involved high-intensity exercises at 90-95% of peak oxygen consumption. Diet groups received cinnamon supplements at the rate of 6 grams/day for a period of 8 weeks. Body measurements (weight, body mass index) and serum levels of blood fats (cholesterol, triglyceride, high-density lipoprotein, low-density lipoprotein) were measured before and after the study. The data were analyzed using the dependent t-test and analysis of covariance at a level less than 0.05.Results: After 8 weeks of intervention, a significant decrease in body weight and body mass index and a significant increase in HDL cholesterol were observed in the intense interval training and intense interval training + cinnamon groups compared to the cinnamon alone group (p≤0.05). However, Bonferroni's follow-up test did not show significant differences in cholesterol, triglyceride and low-density lipoprotein levels between the groups (p≥0.05).Conclusion: High-intensity intermittent exercise with cinnamon consumption can reduce body composition and some blood lipids more effectively than cinnamon supplementation in overweight high school girls.
Ouerghi, N., Fradj, M. K. B., Bezrati, I., Khammassi, M., Feki, M., Kaabachi, N., & Bouassida, A. (2017). Effects of high-intensity interval training on body composition, aerobic and anaerobic performance and plasma lipids in overweight/obese and normal-weight young men. Biology of sport, 34(4), 385-392.
Mousavi, S. M., Karimi, E., Hajishafiee, M., Milajerdi, A., Amini, M. R., & Esmaillzadeh, A. (2020). Anti-hypertensive effects of cinnamon supplementation in adults: A systematic review and dose-response Meta-analysis of randomized controlled trials. Critical Reviews in Food Science and Nutrition, 60(18), 3144-3154.
Pulungan, A., & Pane, Y. S. (2020). The benefit of cinnamon (Cinnamomum burmannii) in lowering total cholesterol levels after consumption of high-fat containing foods in white mice (Mus musculus) models. F1000Research, 9.
Alsoodeeri, F. N., Alqabbani, H. M., & Aldossari, N. M. (2020). Effects of cinnamon (Cinnamomum cassia) consumption on serum lipid profiles in albino rats. Journal of lipids.
Zhu, C., Yan, H., Zheng, Y., Santos, H. O., Macit, M. S., & Zhao, K. (2020). Impact of cinnamon supplementation on cardiometabolic biomarkers of inflammation and oxidative stress: a systematic review and meta-analysis of randomized controlled trials. Complementary therapies in medicine, 53, 102517.
Hadipour, E., Shahangian, S. S., Ramazani, E., & Salmasi, Z. (2023). Effect of Cinnamon and its Biologically Active Compounds on the Components and Symptoms of Metabolic Syndrome. Journal of Mazandaran University of Medical Sciences, 33(219), 123-140.
Ainehchi, N., Khaki, A., Farshbaf-Khalili, A., Hammadeh, M., & Ouladsahebmadarek, E. (2019). The effectiveness of herbal mixture supplements with and without clomiphene citrate in comparison to clomiphene citrate on serum antioxidants and glycemic biomarkers in women with polycystic ovary syndrome willing to be pregnant: a randomized clinical trial. Biomolecules, 9(6), 215.
Hadipour, E., Fereidoni, M., Tayarani, Najaran, Z. (2020). Betanin attenuates oxidative stress induced by 6-OHDA in PC12 cells via SAPK/JNK and PI3 K pathways. Neurochem Res. 45(2): 395-403.
Buchan, D. S., Ollis, S., Young, J. D., Cooper, S. M., Shield, J. P., & Baker, J. S. (2013). High intensity interval running enhances measures of physical fitness but not metabolic measures of cardiovascular disease risk in healthy adolescents. BMC public health, 13(1), 1-12.
Racil, G., Ben Ounis, O., Hammouda, O., Kallel, A., Zouhal, H., Chamari, K., & Amri, M. (2013). Effects of high vs. moderate exercise intensity during interval training on lipids and adiponectin levels in obese young females. European journal of applied physiology, 113(10), 2531-2540.
Hadipour, E., Tayarani, Najaran, Z., Fereidoni, M. (2020). Vitamin K2 protects PC12 cells against Aβ (1-42) and H2O2-induced apoptosis via p38 MAP kinase pathway. Nutr Neurosci. 23(5): 343-352.
Wang, J. G., Anderson, R. A., Graham III, G. M., Chu, M. C., Sauer, M. V., Guarnaccia, M. M., & Lobo, R. A. (2007). The effect of cinnamon extract on insulin resistance parameters in polycystic ovary syndrome: a pilot study. Fertility and sterility, 88(1), 240-243.
Park, S. Y., Kim, Y. D., Kim, M. S., Kim, K. T., & Kim, J. Y. (2023). Cinnamon (Cinnamomum cassia) water extract improves diarrhea symptoms by changing the gut environment: a randomized controlled trial. Food & Function, 14(3), 1520-1529.
World Health Organization. Obesity and Overweight. (2021). Available online: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight (accessed on 19 May 2022).
Mousavi, S. M., Rahmani, J., Kord-Varkaneh, H., Sheikhi, A., Larijani, B., & Esmaillzadeh, A. (2020). Cinnamon supplementation positively affects obesity: A systematic review and dose-response meta-analysis of randomized controlled trials. Clinical Nutrition, 39(1), 123-133.
Jamali, N., Kazemi, A., Saffari-Chaleshtori, J., Samare-Najaf, M., Mohammadi, V., & Clark, C. C. (2020). The effect of cinnamon supplementation on lipid profiles in patients with type 2 diabetes: A systematic review and meta-analysis of clinical trials. Complementary Therapies in Medicine, 55, 102571.
Camacho, S., et al. (2015). Anti-obesity and anti-hyperglycemic effects of cinnamaldehyde via altered ghrelin secretion and functional impact on food intake and gastric emptying. Scientific reports. 5: p. 7919.
Miyazaki, M., et al. (2012). Increased hepatic expression of dipeptidyl peptidase-4 in non-
alcoholic fatty liver disease and its association with insulin resistance and glucose metabolism. Molecular medicine reports. 5(3): p. 729-733.
Chao, M., et al. (2009). Improving insulin resistance with traditional Chinese medicine in type diabetic patients. Endocrine. 36(2): p. 268-274.
Gurd, B.J., et al. (2010). High-intensity interval training increases SIRT1 activity in human
skeletal muscle. Applied Physiology, Nutrition, and Metabolism. 35(3): p. 350-357.
Rashidlamir A , Alizadeh A, Ebrahimiatri A, Dastani M. (2012). The Effect of Four-Week Period of Aerobic Exercise with Cinnamon Consumption on Lipoprotein Indicates and Blood sugar in Diabetic Female Patients (Type 2). Journal of Shahid Sadoughi University of Medical ciences. Vol. 20, No. 5, Nov- Pages: 605-614.
Biddle, S.J. and A.M. Batterham. (2015). High-intensity interval exercise training for public health: a big HIT or shall we HIT it on the head? International Journal of Behavioral Nutrition and Physical Activity. 12(1): p. 95.
Tayarani, Najaran, Z., Hadipour, E., Mousavi, SM., Emami, SA., Mohtashami, L., Javadi, B. (2021). Protective effects of Lavandula stoechas L. methanol extract against 6-OHDA-induced apoptosis in PC12 cells J. Ethnopharmacol. 273: 14023.
Keramati, M., Musazadeh, V., Malekahmadi, M., Jamilian, P., Jamilian, P., Ghoreishi, Z., et al. (2022). Cinnamon, an effective anti-obesity agent:Evidence from an umbrella meta-analysis. J Food Biochem. 46(8): 14166.
Santos, HO., da, Silva, GA. (2018) To what extent does cinnamon administration improve the glycemic and lipid profiles? Clin Nutr ESPEN. 27:1-9.
Dehghan, T., & Abedi, B. (2020). Effect of 12-Week Body Pump with Consumption of Cinnamon and Honey on Resistin, Visfatin and Insulin Resistance in Overweight Children. Iranian Journal of Nutrition Sciences & Food Technology, 15(1), 1-10.
Ainehchi, N., Khaki, A., Farshbaf-Khalili, A., Hammadeh, M., & Ouladsahebmadarek, E. (2019). The effectiveness of herbal mixture supplements with and without clomiphene citrate in comparison to clomiphene citrate on serum antioxidants and glycemic biomarkers in women with polycystic ovary syndrome willing to be pregnant: a randomized clinical trial. Biomolecules, 9(6), 215.
Wu, T., Huang, W., He, M., Yue, R. (2022). Effects of cinnamon supplementation on lipid profiles among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis. Complement Ther Clin Pract. 49: 101625.
Maleki, S., Behpoor, N., & Tadibi, V. (2020). Effect of 8 weeks of resistance training and supplementation of cinnamon on plasma levels of leptin and adiponectin in overweight women. Journal of Practical Studies of Biosciences in Sport, 8(16), 132-142.
Ohnuma, K., R. Hatano, and C. (2015). Morimoto, DPP4 in anti-tumor immunity: going beyond the enzyme. Nature immunology. 16(8): p. 791.
Meissner, E.G., et al. (2015). Dynamic changes of post-translationally modified forms of CXCL10 and soluble DPP4 in HCV subjects receiving interferon-free therapy. PLoS One. 10 (7): p. e0133236.
Malin, S.K., et al. (2013). Lower dipeptidyl peptidase-4 following exercise training plus weight loss is related to increased insulin sensitivity in adults with metabolic syndrome. Peptides. 47: p. 142-147.
