تاثیر شش هفته تمرین تناوبی شدید و کورکومین بر سطوح گلوکز و بیان ژن BMP-2 در عضله صاف عروقی موش‌های صحرایی نر دیابتی

الموضوعات : فصلنامه زیست شناسی جانوری

رضا شیخ ¹ (گروه فیزیولوژی ورزشی دانشکده علوم ورزشی، دانشگاه شهید چمران اهواز، اهواز، ایران)
محمد گله داری ² (گروه تربیت بدنی، دانشکده علوم انسانی، دانشگاه آزاد اسلامی واحد اهواز، ایران)

تاريخ الإرسال : 25 الأربعاء , ذو القعدة, 1444 تاريخ التأكيد : 30 الأحد , ربيع الأول, 1445 تاريخ الإصدار : 23 الجمعة , جمادى الثانية, 1445

الکلمات المفتاحية: تمرین تناوبي, BMP2 , كوركومين, ديابت,

ملخص المقالة :

مطالعه¬ي حاضر با هدف بررسي تاثير شش هفته تمرين تناوبي و مصرف كوركومين بر بیان ژن BMP2 در عضله صاف عروقی موش‌هاي صحرايي نر نژاد ويستار انجام شد. در يك كارآزمايي تجربي تعداد 30 سر موش صحرايي نر ويستار به طور تصادفي به شش گروه (هر گروه 5 سر موش) كنترل، ديابت، سالم تمرين تناوبي، ديابت تمرين تناوبي، ديابت كوركومين و ديابت تمرين كوركومين تقسيم شدند. ديابت با تزريق درون صفاقي سم استرپتوزوتوسين (50 ميلي¬گرم به ازاي هر كيلوگرم) القاء شد. تمرين تناوبي شامل 12-5 وهله كار شديد (75 تا 100 درصد بيشينه سرعت) 60 ثانيه¬اي با فواصل استراحت فعال 75 ثانيه اي شش روز در هفته به مدت شش هفته بود. كوركومين با دوز 50 ميلي¬گرم در كيلوگرم از وزن بدن به روش گاواژ به حيوانات خورانده شد. پس از شش هفته حيوانات بي هوش و نمونه‌هاي خوني از قلب آنها جمع¬آوري شد. داده¬ها با استفاده از آزمون آماري ANOVA و آزمون تعقيبي بن فروني تحليل شدند. القاء ديابت بیان ژنBMP2 در عضله صاف عروقی موش صحرایی نر را افزایش داد. تمرين تناوبي بیان ژن BMP2 عضله صاف عروقی موش مبتلا به دیابت را کاهش داد. شش هفته مصرف كوركومين بیان ژن BMP2 عضله صاف عروقی موش مبتلا به دیابت را كاهش داد. به طور كلي نتايج مطالعه¬ي حاضر نشان داد كه تمرين تناوبي و كوركومين، اختلالات ديابت ناشی از بیان ژن BMP2 و کلسیفیکاسیون و عوارض آن را بهبود مي¬دهند.

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